scholarly journals Mass spectrometry imaging and monitoring of in vivo glutathione-triggered cisplatin release from nanoparticles in the kidneys

2020 ◽  
Vol 2 (12) ◽  
pp. 5857-5865
Author(s):  
Arthur C. K. Chung ◽  
Xuan Li ◽  
Wai-Chung Li ◽  
Tao Wang ◽  
Hin-Kiu Lee ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Broad Spectrum ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications ◽  
Chemotherapeutic Drug

An increasing number of studies have reported the use of various nanoparticles to encapsulate cisplatin, a frontline chemotherapeutic drug against a broad-spectrum of cancers, for overcoming its inherent drawbacks in clinical applications.

scholarly journals Mass Spectrometry Imaging (MSI) Delineates Thymus-Centric Metabolism In Vivo as an Effect of Systemic Administration of Dexamethasone

2021 ◽  
Vol 11 (22) ◽  
pp. 11038
Author(s):  
Yudai Tsuji ◽  
Shinichi Yamaguchi ◽  
Tomoyuki Nakamura ◽  
Masaya Ikegawa
Keyword(s):  
Mass Spectrometry ◽  
Single Molecule ◽  
Mass Spectrometry Imaging ◽  
Apoptotic Cell ◽  
Systemic Administration ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Energy Status ◽  
Cortex Of The Thymus

Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is increasingly used in a broad range of research due to its ability to visualize the spatial distribution of metabolites in vivo. Here, we have developed a method, named thoracic Mass Spectrometry Imaging (tMSI), as a standard protocol of molecular imaging of whole-animal sectioning in various settings of mice in vivo. Further application of the strategy that involved the systemic administration of dexamethasone (DEX) in mice, enabled a dynamic shift in the energy status of multiple thoracic organs to be visualized, based on tMSI data of purine and pyrimidine metabolites. Furthermore, with the introduction of uniform manifold approximation and projection (UMAP) for tMSI data, metabolic profiles normally localized in the cortex and cortico-medullary junction (CMJ) of the thymus were drastically shifted as minor profiles into the medulla of DEX-treated thymus. As a massive apoptotic cell death in the thymic cortex was noticeable, a single molecule, which was upregulated in the cortex of the thymus, enabled us to predict ongoing immunosuppression by in vivo DEX-administration.

scholarly journals Robot-Assisted SpiderMass for in vivo Real-Time Topography Mass Spectrometry Imaging

2020 ◽  
Author(s):  
Nina Ogrinc ◽  
Alexandre Kruszewski ◽  
Paul Chaillou ◽  
Philippe Saudemont ◽  
Chann Lagadec ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Ex Vivo ◽  
Sample Surface ◽  
Molecular Data ◽  
Whole Body ◽  
Robotic Arm ◽  
Whole Body Imaging ◽  
Excision Margins

Mass Spectrometry Imaging (MSI) has shown to bring invaluable information for biological and clinical applications. However, conventional MSI is generally performed ex vivo from tissue sections. Here, we develop a novel MS-based method for in vivo mass spectrometry imaging. By coupling the SpiderMass technology, that provides in vivo minimally invasive analysis, to a robotic arm of high accuracy, we demonstrate that images can be acquired from any surface by moving the laser probe above the surface. By equipping the robotic arm with a sensor, we are also able to both get the topography image of the sample surface and the molecular distribution, and then and plot back the molecular data, directly to the 3D topographical image without the need for image fusion. This is shown for the first time with the 3D topographic MS-Based whole-body imaging of a mouse. Enabling fast in vivo MSI bridged to topography pave the way for surgical applications to excision margins.

P3-071: IN VIVO STABLE ISOTOPE LABELING AND QUANTITATIVE MASS SPECTROMETRY IMAGING OF Aβ PLAQUE DEPOSITION AND TAUOPATHY IN HUMAN AD BRAIN

2006 ◽  
Vol 14 (7S_Part_20) ◽  
pp. P1091-P1092
Author(s):  
Norelle C. Wildburger ◽  
Greg S. Day ◽  
Wendy Sigurdson ◽  
Melissa Sullivan ◽  
Amanda Peters ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Mass Spectrometry Imaging ◽  
Isotope Labeling ◽  
Stable Isotope Labeling ◽  
Quantitative Mass Spectrometry ◽  
Plaque Deposition

scholarly journals Emerging applications in mass spectrometry imaging; enablers and roadblocks

2020 ◽  
Author(s):  
Cristina Russo ◽  
Cameron Heaton ◽  
Lucy Flint ◽  
Oana Voloaca ◽  
Sarah Haywood-Small ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications ◽  
Widespread Application ◽  
Wide Range ◽  
Extensive Range ◽  
Technical Advances ◽  
Versatile Technique ◽  
Clinical Drug

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

scholarly journals Localization of sunitinib in in vivo animal and in vitro experimental models by MALDI mass spectrometry imaging

2014 ◽  
Vol 407 (8) ◽  
pp. 2245-2253 ◽  
Author(s):  
James J. Connell ◽  
Yutaka Sugihara ◽  
Szilvia Török ◽  
Balázs Döme ◽  
József Tóvári ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Experimental Models ◽  
Maldi Mass Spectrometry Imaging

scholarly journals Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1141-1149
Author(s):  
Kristoffer Hendel ◽  
Anders C. N. Hansen ◽  
Liora Bik ◽  
Charlotte Bagger ◽  
Martijn B. A. van Doorn ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Delivery ◽  
Mass Spectrometry Imaging ◽  
Needle Injection

In vivo Distribution of Tiotropium in a Rodent Model Utilizing AP-SMALDI Mass Spectrometry Imaging

2017 ◽  
Vol 13 (3) ◽  
pp. 182-186 ◽  
Author(s):  
Akos Vegvari ◽  
Thomas E. Fehniger ◽  
Magnus Dahlback ◽  
Gyorgy Marko-Varga ◽  
Kerstin Strupat
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Rodent Model ◽  
In Vivo Distribution

Mass spectrometry imaging and tissue microproteomic for clinical applications

2014 ◽  
Vol 185 ◽  
pp. S11
Author(s):  
Michel Salzet ◽  
Maxence Wisztorski ◽  
Julien Franck ◽  
Eric Leblanc ◽  
Denis Vinatier ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications
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