Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications

2021 ◽  
Author(s):  
Khalil Mallah ◽  
Kazem Zibara ◽  
Coline Kerbaj ◽  
Ali Eid ◽  
Nour Khoshman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Target Identification ◽  
Clinical Applications

scholarly journals Mass spectrometry imaging and monitoring of in vivo glutathione-triggered cisplatin release from nanoparticles in the kidneys

2020 ◽  
Vol 2 (12) ◽  
pp. 5857-5865
Author(s):  
Arthur C. K. Chung ◽  
Xuan Li ◽  
Wai-Chung Li ◽  
Tao Wang ◽  
Hin-Kiu Lee ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Broad Spectrum ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications ◽  
Chemotherapeutic Drug

An increasing number of studies have reported the use of various nanoparticles to encapsulate cisplatin, a frontline chemotherapeutic drug against a broad-spectrum of cancers, for overcoming its inherent drawbacks in clinical applications.

scholarly journals Emerging applications in mass spectrometry imaging; enablers and roadblocks

2020 ◽  
Author(s):  
Cristina Russo ◽  
Cameron Heaton ◽  
Lucy Flint ◽  
Oana Voloaca ◽  
Sarah Haywood-Small ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications ◽  
Widespread Application ◽  
Wide Range ◽  
Extensive Range ◽  
Technical Advances ◽  
Versatile Technique ◽  
Clinical Drug

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

Mass spectrometry imaging and tissue microproteomic for clinical applications

2014 ◽  
Vol 185 ◽  
pp. S11
Author(s):  
Michel Salzet ◽  
Maxence Wisztorski ◽  
Julien Franck ◽  
Eric Leblanc ◽  
Denis Vinatier ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Clinical Applications

scholarly journals Sample preparation strategy for the detection of steroid-like compounds using MALDI mass spectrometry imaging: pulmonary distribution of budesonide as a case study

2021 ◽  
Author(s):  
Riccardo Zecchi ◽  
Pietro Franceschi ◽  
Laura Tigli ◽  
Davide Amidani ◽  
Chiara Catozzi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Adult Rabbit ◽  
Chronic Obstructive ◽  
Ionization Mass ◽  
Obstructive Pulmonary Disease ◽  
Imaging Protocol ◽  
Girard’S Reagent

AbstractCorticosteroids as budesonide can be effective in reducing topic inflammation processes in different organs. Therapeutic use of budesonide in respiratory diseases, like asthma, chronic obstructive pulmonary disease, and allergic rhinitis is well known. However, the pulmonary distribution of budesonide is not well understood, mainly due to the difficulties in tracing the molecule in lung samples without the addition of a label. In this paper, we present a matrix-assisted laser desorption/ionization mass spectrometry imaging protocol that can be used to visualize the pulmonary distribution of budesonide administered to a surfactant-depleted adult rabbit. Considering that budesonide is not easily ionized by MALDI, we developed an on-tissue derivatization method with Girard’s reagent P followed by ferulic acid deposition as MALDI matrix. Interestingly, this sample preparation protocol results as a very effective strategy to raise the sensitivity towards not only budesonide but also other corticosteroids, allowing us to track its distribution and quantify the drug inside lung samples. Graphical abstract

scholarly journals Shotgun lipidomics and mass spectrometry imaging unveil diversity and dynamics in Gammarus fossarum lipid composition

iScience ◽  
2021 ◽  
Vol 24 (2) ◽  
pp. 102115
Author(s):  
Tingting Fu ◽  
Oskar Knittelfelder ◽  
Olivier Geffard ◽  
Yohann Clément ◽  
Eric Testet ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lipid Composition ◽  
Mass Spectrometry Imaging ◽  
Shotgun Lipidomics ◽  
Gammarus Fossarum
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