scholarly journals Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes

Lab on a Chip ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 2748-2755 ◽  
Author(s):  
Juan Manuel Martinez Galvez ◽  
Maite Garcia-Hernando ◽  
Fernando Benito-Lopez ◽  
Lourdes Basabe-Desmonts ◽  
Anna V. Shnyrova
Keyword(s):  
Surface Chemistry ◽  
Microfluidic Chip ◽  
Lipid Membrane ◽  
Membrane Nanotubes ◽  
Microfluidic Chamber ◽  
Pillar Arrays

Microarray surface chemistry and design set the geometry of lipid membrane nanotubes easily formed and observed in a microfluidic chamber.

Formation and Stability of Lipid Membrane Nanotubes

ACS Nano ◽  
2017 ◽  
Vol 11 (9) ◽  
pp. 9558-9565 ◽  
Author(s):  
Amir Houshang Bahrami ◽  
Gerhard Hummer
Keyword(s):  
Lipid Membrane ◽  
Membrane Nanotubes

Size-dependent formation of membrane nanotubes: continuum modeling and molecular dynamics simulations

2018 ◽  
Vol 20 (5) ◽  
pp. 3474-3483 ◽  
Author(s):  
Falin Tian ◽  
Tongtao Yue ◽  
Wei Dong ◽  
Xin Yi ◽  
Xianren Zhang
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Lipid Membrane ◽  
Continuum Theory ◽  
Mechanical Behaviors ◽  
Continuum Modeling ◽  
Membrane Nanotubes ◽  
Size Dependent ◽  
Structural Lipid ◽  
Dynamics Simulations

With continuum theory and molecular dynamics simulations we demonstrated that the lipid membrane upon extraction exhibits size- and tension-dependent mechanical behaviors, and different structural lipid rearrangements in different leaflets.

Spontaneous shape transformation of free-floating lipid membrane nanotubes

Soft Matter ◽  
2013 ◽  
Vol 9 (21) ◽  
pp. 5155 ◽  
Author(s):  
Natalia Stepanyants ◽  
Haijiang Zhang ◽  
Tatsiana Lobovkina ◽  
Paul Dommersnes ◽  
Gavin D. M. Jeffries ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Shape Transformation ◽  
Membrane Nanotubes

Permeation of nanoparticles across the intestinal lipid membrane: dependence on shape and surface chemistry studied through molecular simulations

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6318-6333 ◽  
Author(s):  
Rakesh Gupta ◽  
Yogesh Badhe ◽  
Samir Mitragotri ◽  
Beena Rai
Keyword(s):  
Drug Delivery ◽  
Surface Chemistry ◽  
In Silico ◽  
Lipid Membrane ◽  
Oral Drug Delivery ◽  
Molecular Simulations ◽  
Oral Drug ◽  
Drug Delivery Applications

In-silico design & testing of nanoparticles for oral drug delivery applications.

Chapter 2b: The molecular antigenic structure of the TBEV

2020 ◽  
Keyword(s):  
Conformational Changes ◽  
Neutralizing Antibodies ◽  
Lipid Membrane ◽  
Cell Entry ◽  
Antigenic Structure ◽  
E Proteins ◽  
Amino Acid Sequence Level ◽  
Endosomal Membrane ◽  
E Protein ◽  
Golgi Network

TBEV-particles are assembled in an immature, noninfectious form in the endoplasmic reticulum by the envelopment of the viral core (containing the viral RNA) by a lipid membrane associated with two viral proteins, prM and E. Immature particles are transported through the cellular exocytic pathway and conformational changes induced by acidic pH in the trans-Golgi network allow the proteolytic cleavage of prM by furin, a cellular protease, resulting in the release of mature and infectious TBE-virions. The E protein controls cell entry by mediating attachment to as yet ill-defined receptors as well as by low-pH-triggered fusion of the viral and endosomal membrane after uptake by receptor-mediated endocytosis. Because of its key functions in cell entry, the E protein is the primary target of virus neutralizing antibodies, which inhibit these functions by different mechanisms. Although all flavivirus E proteins have a similar overall structure, divergence at the amino acid sequence level is up to 60 percent (e.g. between TBE and dengue viruses), and therefore cross-neutralization as well as (some degree of) cross-protection are limited to relatively closely related flaviviruses, such as those constituting the tick-borne encephalitis serocomplex.

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