Luteolin cooperated with metformin hydrochloride alleviates lipid metabolism disorders and optimizes intestinal flora compositions of high-fat diet mice

2020 ◽  
Vol 11 (11) ◽  
pp. 10033-10046
Author(s):  
Xiaodong Ge ◽  
Chang'e Wang ◽  
Huiling Chen ◽  
Tingting Liu ◽  
Ligen Chen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Signaling Pathways ◽  
High Fat Diet ◽  
Intestinal Flora ◽  
Metformin Hydrochloride ◽  
High Fat ◽  
Lipid Metabolism Disorders

LU·MH regulates lipid metabolism signaling pathways and intestinal flora to alleviate lipid metabolism disorders of high-fat diet mice.

scholarly journals 1H-NMR Metabolomics Analysis of the Effect of Rubusoside on Serum Metabolites of Golden Hamsters on a High-Fat Diet

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1274
Author(s):  
Li Li ◽  
Manjing Jiang ◽  
Yaohua Li ◽  
Jian Su ◽  
Li Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Amino Acid ◽  
1H Nmr ◽  
High Fat Diet ◽  
Ketone Bodies ◽  
High Fat ◽  
Nmr Metabolomics ◽  
Metabolism Regulation ◽  
Golden Hamsters ◽  
Lipid Metabolism Disorders

Rubusoside is a natural sweetener and the active component of Rubus suavissimus. The preventive and therapeutic effect of rubusoside on high-fat diet-induced (HFD) serum metabolite changes in golden hamsters was analyzed by 1H-NMR metabolomics to explore the underlying mechanism of lipid metabolism regulation. 1H-NMR serum metabolomics analyses revealed a disturbed amino acid-, sugar-, fat-, and energy metabolism in HFD animals. Animals supplemented with rubusoside can partly reverse the metabolism disorders induced by high-fat diet and exerted good anti-hypertriglyceridemia effect by intervening in some major metabolic pathways, involving amino acid metabolism, synthesis of ketone bodies, as well as choline and 4-hydroxyphenylacetate metabolism. This study indicates that rubusoside can interfere with and normalize high-fat diet-induced metabolic changes in serum and could provide a theoretical basis to establish rubusoside as a potentially therapeutic tool able to revert or prevent lipid metabolism disorders.

scholarly journals Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 265 ◽  
Author(s):  
Caixia Guo ◽  
Li Han ◽  
Meiping Li ◽  
Ligang Yu
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
High Fat Diet ◽  
High Fat ◽  
Beneficial Bacteria ◽  
Diet Induced Obesity ◽  
Lipid Metabolism Disorders ◽  
Freeze Dried ◽  
Genes Encoding

This study aimed to investigate the beneficial effects of seabuckthorn freeze-dried powder on high-fat diet-induced obesity and related lipid metabolism disorders, and further explored if this improvement is associated with gut microbiota. Results showed that seabuckthorn freeze-dried powder administration decreased body weight, Lee’s index, adipose tissue weight, liver weight, and serum lipid levels. Moreover, treatment with seabuckthorn freeze-dried powder effectively reduced fat accumulation by modulating the relative expression of genes involved in lipid metabolism through down-regulation of encoding lipogenic and store genes, including SREBP-1c, PPAR-γ, ACC, and SCD1, and up-regulation of regulating genes of fatty acid oxidation, including HSL, CPT-1, and ACOX. Especially, seabuckthorn freeze-dried powder regulated the composition of gut microbiota, such as increasing the ratio of Firmicutes/Bacteroidetes, decreasing relative abundance of harmful bacteria (Desulfovibrio), and increasing relative abundance of beneficial bacteria (Akkermansia and Bacteroides). The changes of beneficial bacteria had a positive correlation with genes encoding lipolysis and a negative correlation with genes encoding lipid lipogenesis and store. The harmful bacteria were just the opposite. Besides, changes in gut microbiota had an obvious effect in the secretion of main metabolites—short-chain fatty acids (SCFAs), especially propionic acid. Thus, our results indicated that the seabuckthorn freeze-dried powder could ameliorate high-fat diet-induced obesity and obesity-associated lipid metabolism disorders by changing the composition and structure of gut microbiota.

scholarly journals Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1513
Author(s):  
Juan Wan ◽  
Meiyan Feng ◽  
Wenjing Pan ◽  
Xin Zheng ◽  
Xinya Xie ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Inhibitory Effect ◽  
Premature Aging ◽  
High Fat ◽  
Amyloid A ◽  
Significant Inhibitory Effect ◽  
Lipid Metabolism Disorders ◽  
Age Related

Aging and lipid metabolism disorders promote the formation and accumulation of amyloid with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 diabetes, and other senile degenerative diseases. In this study, five representative teas were selected from each of the six types of tea, and a total of 30 teas were selected to evaluate the inhibitory activities on the formation of aging-related amyloid in vitro. The results showed that the 30 teas had a significant inhibitory effect on the formation activity on aging-related amyloid at the protein level in vitro. Although the content of catechins is relatively low, black tea and dark tea still have significant antioxidant activity and inhibit the formation of amyloid. A high-fat diet established the model of lipid metabolism disorder in premature aging SAMP8 mice, and these mice were gavaged different tea water extracts. The results showed that different tea types have a significant inhibitory effect on the formation of β-amyloid and Aβ42 mediated by age-related lipid metabolism disorders, and the in vivo activity of fully fermented teas was better than that of green tea. The action mechanism was related to antioxidation, anti-inflammatory, and improving lipid metabolism.

Lactobacillus paracasei ameliorates cognitive impairment in high-fat induced obese mice via insulin and neuroinflammation signaling pathway

2021 ◽  
Author(s):  
yaoyao ji ◽  
Xinsong Lang ◽  
Wei Wang ◽  
Shengnan Li ◽  
Changhui Zhao ◽  
...  
Keyword(s):  
Nervous System ◽  
Cognitive Impairment ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Glucose And Lipid Metabolism ◽  
Lipid Metabolism Disorders ◽  
The Brain

Long-term consumption of high-fat diet (HFD) can cause glucose and lipid metabolism disorders, damage the brain nervous system and result in cognitive impairment. The objective of this study was to...

The protective mechanisms of macroalgae Laminaria japonica consumption against lipid metabolism disorders in high-fat diet-induced hyperlipidemic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 3256-3270
Author(s):  
Qing Zhang ◽  
Xiao-Yun Fan ◽  
Wei-Ling Guo ◽  
Ying-Jia Cao ◽  
Yi-Chen Lin ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Laminaria Japonica ◽  
High Fat ◽  
Protective Mechanisms ◽  
Alcoholic Fatty Liver ◽  
Lipid Metabolism Disorders ◽  
Alcoholic Fatty Liver Disease

Macroalgae Laminaria japonica (MLJ) consumption could prevent against non-alcoholic fatty liver disease (NAFLD) associated with hyperlipidemia.

The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet

2020 ◽  
Vol 11 (4) ◽  
pp. 3316-3331 ◽  
Author(s):  
Min Chen ◽  
Wei-Ling Guo ◽  
Qiu-Yi Li ◽  
Jia-Xin Xu ◽  
Ying-Jia Cao ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Protective Mechanism ◽  
Rice Wine ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Lipid Metabolism Disorders ◽  
Brewing Process

Lactobacillus plantarum FZU3013, isolated from the traditional brewing process of Hongqu rice wine, has beneficial effects on improving lipid metabolism disorders.

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