The protective mechanisms of macroalgae Laminaria japonica consumption against lipid metabolism disorders in high-fat diet-induced hyperlipidemic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 3256-3270
Author(s):  
Qing Zhang ◽  
Xiao-Yun Fan ◽  
Wei-Ling Guo ◽  
Ying-Jia Cao ◽  
Yi-Chen Lin ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Laminaria Japonica ◽  
High Fat ◽  
Protective Mechanisms ◽  
Alcoholic Fatty Liver ◽  
Lipid Metabolism Disorders ◽  
Alcoholic Fatty Liver Disease

Macroalgae Laminaria japonica (MLJ) consumption could prevent against non-alcoholic fatty liver disease (NAFLD) associated with hyperlipidemia.

Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway

2019 ◽  
Vol 10 (2) ◽  
pp. 814-823 ◽  
Author(s):  
Ke Chen ◽  
Xu Chen ◽  
Hongliang Xue ◽  
Peiwen Zhang ◽  
Wanjun Fang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Coenzyme Q10 ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Ampk Pathway ◽  
Alcoholic Fatty Liver Disease

Coenzyme Q10 regulates lipid metabolism to ameliorate the progression of NAFLD by activating the AMPK pathway.

Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease

2014 ◽  
Vol 5 (12) ◽  
pp. 3216-3223 ◽  
Author(s):  
Chuan Li ◽  
Shao-Ping Nie ◽  
Ke-Xue Zhu ◽  
Qiao Ding ◽  
Chang Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Liver Function ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Possible mechanisms underlying how Lactobacillus plantarum NCU116 improves lipid metabolism in rats with high fat diet induced NAFLD.

Holothuria arenicola extract attenuated hepatic steatosis in splenectomized rat fed high fat diet

2021 ◽  
Vol 11 ◽  
Author(s):  
Shimaa A. Sadek ◽  
Asmaa E. Farouk ◽  
Sohair R. Fahmy ◽  
Amel M. Soliman
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Holothuria Arenicola ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) is a considerable public health concern due to the excessive dietary consumption of high caloric diet and subsequent obesity. Additionally, splenectomy is considered as one of major common risk factor for NAFLD. Objective: Regardless of non-alcoholic fatty liver disease (NAFLD) being the most common chronic disorder, there are no effective cure for it. Therefore, the current study aimed to investigate Holothuria arenicola extract (HaE) efficacy on hepatic steatosis in splenectomized (SPX) rats fed High fat diet (HFD). Methods: Male Wistar rats (n=28) were randomly assigned to four groups: sham rats fed a standard diet, sham rats+ HFD, SPX+HFD and SPX+HFD+HaE. The estimation of hematological and some biochemical parameters as well as oxidative status were analyzed. Results: Oral administration of HaE caused a significant amelioration in all hematological parameters relative to untreated splenectomized rats. Concerning lipid metabolism, HaE treatment caused a pronounced amelioration in lipid metabolism, as indicated by the decreased total cholesterol, triglycerides and LDL-cholesterol contents as well as the increased HDL- cholesterol level. HaE treatment significantly enhanced hepatic function, as exhibited by the reduction in liver enzyme activities as well as the increase of protein and albumin content. Moreover, HaE could retard the hepatic oxidative stress via a pronounced increase in hepatic GSH content and antioxidant enzyme activities besides decreasing in MDA, NO and H2O2 formation. Conclusion: HaE could be utilized as a potential alternative hepatoprotective remedy via lipid metabolism and oxidative damage attenuation.

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