Antidiabetic effects and underlying mechanisms of anti-digestive dietary polysaccharides from Sargassum fusiforme in rats

2020 ◽  
Vol 11 (8) ◽  
pp. 7023-7036 ◽  
Author(s):  
Rui-Bo Jia ◽  
Zhao-Rong Li ◽  
Juan Wu ◽  
Zhi-Rong Ou ◽  
Baoguo Sun ◽  
...  
Keyword(s):  
Active Ingredient ◽  
Inhibitory Activity ◽  
Biologically Active ◽  
Enzymatic Extraction ◽  
Sargassum Fusiforme ◽  
Ultrasound Assisted ◽  
Underlying Mechanisms ◽  
Alpha Glucosidase ◽  
Antidiabetic Effects

Sargassum fusiforme polysaccharides (SFP), an anti-digestive biologically active ingredient obtained from Sargassum fusiforme by ultrasound-assisted enzymatic extraction, have been proven to exhibit extremely strong alpha-glucosidase inhibitory activity.

Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improve insulin-resistant in HepG2 cells

2021 ◽  
Author(s):  
Binkai Han ◽  
Haoqiang Sun ◽  
Xiaolin Yang ◽  
Ting Wang ◽  
Changfen He ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Protective Effects ◽  
Enzymatic Extraction ◽  
Insulin Resistant ◽  
Glucosidase Inhibitors ◽  
First Choice ◽  
Ultrasound Assisted ◽  
Corni Fructus ◽  
Alpha Glucosidase ◽  
Oral Antihyperglycemic Drugs

Corni Fructus (CF) is a traditional medicine and beneficial food with multifaceted protective effects against diabetes and its complications. Since alpha-glucosidase inhibitors (GI) are promising first choice oral antihyperglycemic drugs...

Lactobacillus casei LC89 exert antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice

2021 ◽  
Author(s):  
Yongli Zhang ◽  
Tao Wu ◽  
Wen Li ◽  
Yunjiao Zhao ◽  
Hairong Long ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Molecular Mechanism ◽  
Lactobacillus Casei ◽  
Diabetic Mice ◽  
Antihyperglycemic Activity ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Previous study suggests Lactobacillus casei exhibit antihyperglycemic activity, however, the molecular mechanism has rarely been elucidated. Here, the anti-diabetic effects and underlying mechanisms of Lactobacillus casei LC89 were investigated in...

scholarly journals ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITION ACTIVITY OF SELECTED EDIBLE SEAWEEDS FROM SOUTH COAST AREA OF INDIA

2017 ◽  
Vol 9 (6) ◽  
pp. 64 ◽  
Author(s):  
P. Reka ◽  
Thahira Banu A. ◽  
M. Seethalakshmi
Keyword(s):  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Alpha Amylase ◽  
Postprandial Blood Glucose ◽  
Inhibition Activity ◽  
Gracilaria Edulis ◽  
Edible Seaweeds ◽  
Daily Diet ◽  
Postprandial Blood Glucose Level ◽  
Alpha Glucosidase

Objective: The present work was to investigate the alpha amylase and alpha-glucosidase inhibitory activity of the selected edible seaweeds.Methods: The seaweeds namely Acanthophora spicifera, Gracilaria corticata, Gracilaria edulis, Ulva lactuca and Ulva reticulata were selected for this study. Six and eight hours of ethanol and aqueous extract were used for the estimation of alpha amylase using DNS method and alpha-glucosidase inhibition activity.Results: The study reported that the solvent from ethanol and aqueous in eight hours of extraction showed a higher inhibitory activity than six hours of extraction. Maximum of 89.1±0.96 and 79.55±3.08 percent of alpha-amylase and alpha-glucosidase inhibition activity were detected in the eight hours of aqueous extract (0.5 ml) of Ulva reticulata and Gracilaria edulis respectively. All the selected edible seaweeds had significant differences (p<0.05) in alpha amylase and alpha glucosidase inhibition activity between the selected seaweeds with different extracts.Conclusion: It was concluded that all the selected edible seaweeds have the potential to act as a potent inhibitor of the carbohydrate hydrolyzing enzyme. Thus, it was clear from the study that seaweeds incorporated in small amounts in the dishes consumed in the daily diet can bring a control on postprandial blood glucose level.

scholarly journals Nutritional Composition and .ALPHA.-Glucosidase Inhibitory Activity of Five Chinese Vinegars

2011 ◽  
Vol 45 (4) ◽  
pp. 445-456 ◽  
Author(s):  
JunFeng FAN ◽  
YanYan ZHANG ◽  
LinNa ZHOU ◽  
ZaiGui LI ◽  
BoLin ZHANG ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Nutritional Composition ◽  
Alpha Glucosidase

scholarly journals Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy

2019 ◽  
Vol 10 (4) ◽  
pp. 26-38
Author(s):  
G. G. Avakyan ◽  
T. A. Voronina ◽  
L. N. Nerobkova ◽  
G. N. Avakyan
Keyword(s):  
Status Epilepticus ◽  
Research And Development ◽  
Active Ingredient ◽  
Active Substance ◽  
Drug Transport ◽  
Experimental Models ◽  
Polymer Nanoparticles ◽  
Biologically Active ◽  
Epileptic Focus ◽  
Models Of Epilepsy

The aimis to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.Materials and methods.The nano-drug was created using the biologically active substance 2-ethyl-6-methyl-3-hydroxypyridine succinate and polybutyl cyanoacrylate (PBCA) nanoparticles. The advantages of this nano-form over the active ingredient of the same drug were studied using experimental models: the maximum electroshock test (MES), the antagonism test with corazol, models with a cobaltinduced epileptic focus and secondary generalized convulsions, and models of status epilepticus.Results.The antiseizure effects of the nanoform on the experimental models of epilepsy are identified.Conclusion.The nano-drug reduces the number of secondary generalized clonic-tonic seizures by 7.8 times; it also reduces 10-fold the animal mortality and diminishes the seizure manifestations that occur in the interictal period of the epileptic status.

scholarly journals Preliminary in vitro study of anti-oxidant activity and anti-diabetic potential of plant extracts from 4 herbal substances not traditionally used for treatment of diabetes mellitus

Pharmacia ◽  
2021 ◽  
Vol 68 (4) ◽  
pp. 755-762
Author(s):  
Dora Trifonova ◽  
Anna Gavrilova ◽  
Galina Dyakova ◽  
Genadi Gavrilov ◽  
Maya Yotova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Inhibitory Activity ◽  
In Vitro Study ◽  
Biologically Active ◽  
Total Phenolic ◽  
Water Extracts ◽  
Sambucus Ebulus ◽  
Anti Oxidant ◽  
Treatment Of Diabetes

The focus of the presented study is the in vitro anti-oxidant activity and anti-diabetic potential of water extracts from the following four herbal substances, not traditionally used for treatment of diabetes mellitus – leaves of Sambucus ebulus L. and Prunus mahaleb L., and flowering stems of Cichorium intybus L. and Satureja kitaibelii Wierzb. ex Heuff. The water extracts are obtained through ultrasonication. The extract of S. kitaibelii stands out due to its highest values in all studied indicators – total phenolic content, scavenging potential (DPPH, ABTS) and α-glucosidase inhibitory activity which was six times higher than acarbose. The extract of C. intybus also showed significant α-glucosidase inhibitory activity compared to acarbose. The flowering stems of both species are promising sources of biologically active substances for blood sugar control in diabetes mellitus.

scholarly journals Antioxidant, anti-cholinesterase, anti-α-glucosidase and prebiotic properties of beta-glucan extracted from Algerian barley

2018 ◽  
Vol 10 (1) ◽  
pp. 58 ◽  
Author(s):  
Saad Mebrek ◽  
Hanene Djeghim ◽  
Yamina Mehdi ◽  
Asma Meghezzi ◽  
Sirajudheen Anwar ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Reducing Power ◽  
Beta Carotene ◽  
Moderate Activity ◽  
Beta Glucan ◽  
Antioxidant Power ◽  
Camel's Milk ◽  
Therapeutic Properties ◽  
Alpha Glucosidase ◽  
Low Activity

<p>Beta-glucan, such as barley-derived beta-glucan (BBG), are homopolysaccharides that have attracted attention by their nutritional and therapeutic properties. The aim of this study was to evaluate the antioxidant power of BBG extracted from local Algerian variety of barley (SAIDA 183), and its acetylcholinesterase, alpha glucosidase inhibitory activity as well as its prebiotic potential by fermentation with lactic acid bacteria isolated from camel’s milk, namely <em>lactococcuslactisssplactis</em> (Lc.l.l) and <em>leuconostocmesenteroidesspmesenteroides</em> (Ln.m.m). The results revealed that BBG exhibited low activity against DPPH and ferric-reducing power (IC<sub>50</sub> 4018.61 ± 656.69 and A<sub>0.5 </sub>at 359.88 ±63.64 µg/mL respectively), in contrast to other antioxidant tests (ABTS, Beta-carotene and CUPRAC) where BBG demonstrated a moderate activity (IC<sub>50</sub> 529.91 ±26.37, IC<sub>50</sub> 161.013±13.322, A<sub>0.5 </sub>529.79 ± 48.65 µg/mL). The scavenging ability of hydroxyl radical and superoxide radical by BBG with an IC<sub>50</sub> at 2268.38±101.57 µg/mL and IC<sub>50</sub> 345.26± 62.32 µg/mL, respectively, while enzymatic inhibition by  BBG exhibited for AChE at IC<sub>50</sub> 859.164 ±64.46 μg/mL , BChE at IC<sub>50</sub> at 725.470 ±30.95 , α-Amylase inhibitory activity at IC<sub>50</sub> 2986.785 ± 37.046  . The bacterial growth of the two strains used in this study is favorably affected by the use of BBG as the only carbon source, in comparison with glucose as a control. In light of these findings, it can be concluded that BBG have shown moderate antioxidant and enzyme inhibitory activities and can be used as a prebiotic by acting synergistically with probiotics in functional food matrices.</p>

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