A comparison between whole mung bean and decorticated mung bean: beneficial effects on the regulation of serum glucose and lipid disorders and the gut microbiota in high-fat diet and streptozotocin-induced prediabetic mice

2020 ◽  
Vol 11 (6) ◽  
pp. 5525-5537 ◽  
Author(s):  
Dianzhi Hou ◽  
Qingyu Zhao ◽  
Laraib Yousaf ◽  
Borui Chen ◽  
Yong Xue ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Mung Bean ◽  
Serum Glucose ◽  
High Fat ◽  
Beneficial Effects ◽  
Lipid Disorders

This study aimed to investigate the beneficial effects of whole and decorticated mung beans on the regulation of serum glucose and lipid disorders in HFD/STZ-induced prediabetic mice, and to further explore their gut microbiota modulatory effects.

The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats

2019 ◽  
Vol 10 (10) ◽  
pp. 6517-6532 ◽  
Author(s):  
Hang Xu ◽  
Chunfang Zhao ◽  
Yutian Li ◽  
Ruiyu Liu ◽  
Mingzhang Ao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Intestinal Barrier ◽  
High Fat ◽  
Barrier Dysfunction ◽  
Fruit Extract ◽  
Intestinal Barrier Dysfunction ◽  
Beneficial Effects ◽  
Obese Rats ◽  
Ameliorative Effect

Pyracantha fortuneana fruit extract (PFE) exhibits beneficial effects on IBF in association with the modulation of glycolipid digestion and gut microbiota in HFD-fed obese rats.

scholarly journals NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marina Sokolova ◽  
Kuan Yang ◽  
Simen H. Hansen ◽  
Mieke C. Louwe ◽  
Martin Kummen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Nlrp3 Inflammasome ◽  
High Fat Diet ◽  
Plasma Metabolites ◽  
Inflammasome Activation ◽  
Microbiota Composition ◽  
High Fat ◽  
Beneficial Effects ◽  
Deficient Mice ◽  
Gut Microbiota Composition

AbstractObesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin resistance, and NLRP3 deficient mice exposed to high fat diet (HFD) appear to be protected from left ventricle (LV) concentric remodeling. Herein, we investigated if these beneficial effects were associated with alterations in plasma metabolites, using metabolomic and lipidomic analysis, and gut microbiota composition, using 16S rRNA sequencing of cecum content, comparing NLRP3 deficient and wild type (WT) mice on HFD and control diet. Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice. These changes were accompanied by an altered composition of gut microbiota associated with decreased systemic levels of tri-methylamine-N-oxide and lipopolysaccharide, potentially inducing attenuating systemic inflammation and beneficial effects on lipid metabolism. Our findings support a role of NLRP3 inflammasome in the interface between metabolic and inflammatory stress, involving an altered gut microbiota composition.

A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota

2017 ◽  
Vol 8 (12) ◽  
pp. 4644-4656 ◽  
Author(s):  
Le Zhao ◽  
Qi Zhang ◽  
Weini Ma ◽  
Feng Tian ◽  
Hongyi Shen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Beneficial Effects ◽  
Gut Microbiota Dysbiosis

Administration of a combination of quercetin and resveratrol may have beneficial effects on ameliorating HFD-induced obesity and reducing HFD-induced gut microbiota dysbiosis.

Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

2020 ◽  
Vol 131 ◽  
pp. 108994 ◽  
Author(s):  
Chen Yang ◽  
Zhenxia Xu ◽  
Qianchun Deng ◽  
Qingde Huang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Beneficial Effects
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