scholarly journals Unravelling the cellular emission fingerprint of the benchmark G-quadruplex-interactive compound Phen-DC3

2020 ◽  
Vol 56 (91) ◽  
pp. 14251-14254
Author(s):  
Marco Deiana ◽  
Jan Jamroskovic ◽  
Ikenna Obi ◽  
Nasim Sabouri
Keyword(s):  
Optical Properties ◽  
Cancer Cells ◽  
Binding Interactions ◽  
G Quadruplex

The G4-interactive binding interactions enable one to tune the optical properties of Phen-DC3, allowing the detection of G4 structures in cancer cells.

scholarly journals Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

2020 ◽  
Vol 63 (6) ◽  
pp. 3090-3103 ◽  
Author(s):  
Jussara Amato ◽  
Giulia Miglietta ◽  
Rita Morigi ◽  
Nunzia Iaccarino ◽  
Alessandra Locatelli ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Genome Instability ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
G Quadruplex ◽  
Selective Ligands

scholarly journals Development of a series of bis-triazoles as G-quadruplex ligands

RSC Advances ◽  
2017 ◽  
Vol 7 (75) ◽  
pp. 47297-47308 ◽  
Author(s):  
Maysaa M. Saleh ◽  
Charles A. Laughton ◽  
Tracey D. Bradshaw ◽  
Christopher J. Moody
Keyword(s):  
Cancer Cells ◽  
Enzyme Complex ◽  
Normal Cells ◽  
G Quadruplex ◽  
Key Factor

Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells.

scholarly journals Synthesis, Characterization and Anticancer Evaluation of Nitrogen Substituted 1-(3-Aminoprop-1-ynyl)-4-Hydroxyanthraquinone Derivatives

2021 ◽  
Author(s):  
Nafisa S. Sirazhetdinova ◽  
Dmitry S Baev ◽  
Victor A. Savelyev ◽  
Tatyana S. Golubeva ◽  
Lyubov S. Klimenko ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Sonogashira Reaction ◽  
Secondary Amines ◽  
One Pot ◽  
Standard Drug ◽  
Three Component Reaction ◽  
G Quadruplex ◽  
New Compounds ◽  
Substituted 1 ◽  
Mcf 7

Abstract Anthraquinones are of significant interest due to their biological activity, coloring properties and synthetic applications. Here, we describe a mild and convenient method for modification of 1-ethynyl-4-hydroxyanthraquinone that was obtained from the Sonogashira reaction of 1-hydroxy-4-iodoanthraquinone with alkynes. The copper(I) catalyzed one-pot three component reaction (A3-coupling) of the new 1-ethynyl-4-hydroxyanthraquinone with secondary amines and formaldehyde was the main approach for the synthesis of nitrogen substituted 1-[3-(amino)prop-1-ynyl]-4-hydroxyanthraquinones. The influence of different substituent in the amine on reaction rate and yield has been evaluated. The cytotoxicity of 1-ethynyl-4-hydroxyanthraquinones was evaluated using the conventional MTT assay. Among all the compounds synthesized, anthraquinone-propargylamine derivatives 28, 29, 30 and 34 possess most promising cytotoxic potential towards glioblastoma cancer cells; compounds 14 and 19 shown selectivity towards the prostate cancer cells DU-145, and 18, and 24 – towards breast cancer cells MCF-7. The grown inhibition on these cancer cells of 18 and 24 was comparable to those of standard drug Doxorubicin. Molecular modeling of new compounds in DNA G-quadruplex binding site was performed to help understand the observed SAR trends.

N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage

2011 ◽  
Vol 54 (5) ◽  
pp. 1140-1156 ◽  
Author(s):  
Valentina Casagrande ◽  
Erica Salvati ◽  
Antonello Alvino ◽  
Armandodoriano Bianco ◽  
Alina Ciammaichella ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Effects ◽  
G Quadruplex

scholarly journals N-methyl mesoporphyrin IX as a highly selective light-up probe for G-quadruplex DNA

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1195-1215 ◽  
Author(s):  
Ariana Yett ◽  
Linda Yingqi Lin ◽  
Dana Beseiso ◽  
Joanne Miao ◽  
Liliya A. Yatsunyk
Keyword(s):  
Optical Properties ◽  
Small Molecules ◽  
Genomic Stability ◽  
Water Soluble ◽  
Biological Processes ◽  
Binding Properties ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
G Quadruplex ◽  
High Fluorescence

[Formula: see text]-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with excellent optical properties and unparalleled selectivity for G-quadruplex (GQ) DNA. G-quadruplexes are non-canonical DNA structures formed by guanine-rich sequences. They are implicated in genomic stability, longevity, and cancer. The ability of NMM to selectively recognize GQ structures makes it a valuable scaffold for designing novel GQ binders. In this review, we survey the literature describing the GQ-binding properties of NMM as well as its wide utility in chemistry and biology. We start with the discovery of the GQ-binding properties of NMM and the development of NMM-binding aptamers. We then discuss the optical properties of NMM, focusing on the light-switch effect — high fluorescence of NMM induced upon its binding to GQ DNA. Additionally, we examine the affinity and selectivity of NMM for GQs, as well as its ability to stabilize GQ structures and favor parallel GQ conformations. Furthermore, a portion of the review is dedicated to the applications of NMM-GQ complexes as biosensors for heavy metals, small molecules ([Formula: see text] ATP and pesticides), DNA, and proteins. Finally and importantly, we discuss the utility of NMM as a probe to investigate the roles of GQs in biological processes.

Optical properties of core-multishell quantum dots and their imaging applications in cancer cells

2007 ◽  
Author(s):  
Y. Liu ◽  
P. Chen ◽  
L. Lin ◽  
G.-Q. Tang ◽  
G.-G. Mu
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Cancer Cells

Targeting of G-Quadruplex Harboring Pre-miRNA 92b by LNA Rescues PTEN Expression in NSCL Cancer Cells

2018 ◽  
Vol 13 (4) ◽  
pp. 909-914 ◽  
Author(s):  
Gayan Mirihana Arachchilage ◽  
Prakash Kharel ◽  
Joshua Reid ◽  
Soumitra Basu
Keyword(s):  
Cancer Cells ◽  
Pten Expression ◽  
G Quadruplex

G‐Quadruplex‐Binding Small Molecule Induces Synthetic Lethality in Breast Cancer Cells by Inhibiting c‐MYC and BCL2 Expression

ChemBioChem ◽  
2020 ◽  
Vol 21 (7) ◽  
pp. 963-970 ◽  
Author(s):  
Rakesh Paul ◽  
Tania Das ◽  
Manish Debnath ◽  
Ajay Chauhan ◽  
Jyotirmayee Dash
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Small Molecule ◽  
Breast Cancer Cells ◽  
Synthetic Lethality ◽  
G Quadruplex ◽  
Bcl2 Expression
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