Synthesis and biological evaluation of nitric oxide-releasing hybrids from gemcitabine and phenylsulfonyl furoxans as anti-tumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 1130-1136 ◽  
Author(s):  
Xianghua Li ◽  
Xuemin Wang ◽  
Chenjun Xu ◽  
Junkai Huang ◽  
Chengniu Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Cells ◽  
Biological Evaluation ◽  
Nucleoside Transporter ◽  
Antitumor Activities ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Related Proteins ◽  
Synthesis And Biological Evaluation

Novel furoxan/gemcitabine hybrids displayed significant antitumor activities, in particular 10e, which could be independent of the nucleoside transporter, release high levels of NO, and induce cell apoptosis by regulating apoptotic related proteins in tumor cells in vitro.

scholarly journals Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents

2013 ◽  
Vol 78 (9) ◽  
pp. 1301-1308 ◽  
Author(s):  
Lin Luo ◽  
Jiang-Ke Qin ◽  
Zhi-Kai Dai ◽  
Shi-Hua Gao
Keyword(s):  
Cell Lines ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Structural Factors ◽  
Anticancer Activities ◽  
Antitumor Activities ◽  
Mtt Method ◽  
Human Solid Tumor ◽  
Synthesis And Biological Evaluation

Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships.

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

2016 ◽  
Vol 71 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Ali Almasirad ◽  
Loghman Firoozpour ◽  
Maliheh Nejati ◽  
Najmeh Edraki ◽  
Omidreza Firuzi ◽  
...  
Keyword(s):  
Human Tumor ◽  
Inhibitory Effect ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Ethidium Bromide Staining ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs

2011 ◽  
Vol 8 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Liang Ge ◽  
jingjie Wang ◽  
Xiaoyan Zhang ◽  
Huibin Zhang ◽  
Hai Qian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Evaluation ◽  
Nitric Oxide Releasing ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents

2008 ◽  
Vol 19 (2) ◽  
pp. 149-152 ◽  
Author(s):  
Xiang Wen Kong ◽  
Yi Hua Zhang ◽  
Li Dai ◽  
Hui Ji ◽  
Yi Sheng Lai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Nitric Oxide Releasing ◽  
Synthesis And Biological Evaluation
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