Inflammation-responsive nanocapsules for the dual-release of antibacterial drugs

2020 ◽  
Vol 56 (84) ◽  
pp. 12725-12728
Author(s):  
Arjaree Jobdeedamrong ◽  
Man Theerasilp ◽  
Nattarat Wongsuwan ◽  
Norased Nasongkla ◽  
Daniel Crespy
Keyword(s):  
Wound Healing ◽  
Antibacterial Drugs ◽  
Ph Values ◽  
Dual Release ◽  
Silica Nanocapsules ◽  
Programmed Release

Inflammation-responsive silica nanocapsules allow a programmed release of dual antibiotics at different pH values, corresponding to various stages of wound healing.

Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing

2021 ◽  
pp. 088532822199601
Author(s):  
Linying Shi ◽  
Fang Lin ◽  
Mou Zhou ◽  
Yanhui Li ◽  
Wendan Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Wound Dressings ◽  
Inflammatory Factors ◽  
Gelatin Microspheres ◽  
Infected Wounds ◽  
Dual Release

The ever-growing threats of bacterial infection and chronic wound healing have provoked an urgent need for novel antibacterial wound dressings. In this study, we developed a wound dressing for the treatment of infected wounds, which can reduce the inflammatory period (through the use of gentamycin sulfate (GS)) and enhance the granulation stage (through the addition of platelet-rich plasma (PRP)). Herein, the sustained antimicrobial CMC/GMs@GS/PRP wound dressings were developed by using gelatin microspheres (GMs) loading GS and PRP, covalent bonding to carboxymethyl chitosan (CMC). The prepared dressings exhibited high water uptake capability, appropriate porosity, excellent mechanical properties, sustain release of PRP and GS. Meanwhile, the wound dressing showed good biocompatibility and excellent antibacterial ability against Gram-negative and Gram-positive bacteria. Moreover, in vivo experiments further demonstrated that the prepared dressings could accelerate the healing process of E. coli and S. aureus-infected full-thickness wounds i n vivo, reepithelialization, collagen deposition and angiogenesis. In addition, the treatment of CMC/GMs@GS/PRP wound dressing could reduce bacterial count, inhibit pro-inflammatory factors (TNF-α, IL-1β and IL-6), and enhance anti-inflammatory factors (TGF-β1). The findings of this study suggested that biocompatible wound dressings with dual release of GS and PRP have great potential in the treatment of chronic and infected wounds.

Chitosan membrane dressings toughened by glycerol to load antibacterial drugs for wound healing

2017 ◽  
Vol 81 ◽  
pp. 522-531 ◽  
Author(s):  
Ye Ma ◽  
Lian Xin ◽  
Huaping Tan ◽  
Ming Fan ◽  
Jianliang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Drugs ◽  
Chitosan Membrane

Promoting coagulation and activating SMAD3 phosphorylation in wound healing via a dual-release thrombin-hydrogel

2020 ◽  
Vol 397 ◽  
pp. 125414
Author(s):  
Chongyang Wang ◽  
Tianyi Wu ◽  
Guangwang Liu ◽  
Ruoyu Cheng ◽  
Jian Fei ◽  
...  
Keyword(s):  
Wound Healing ◽  
Smad3 Phosphorylation ◽  
Dual Release

SUSTAINED DUAL RELEASE OF CIPROFLOXACIN AND LIDOCAINE FROM IONIC EXCHANGE RESPONDING FILM BASED ON ALGINATE AND HYALURONATE FOR WOUND HEALING

2021 ◽  
pp. 105789
Author(s):  
Sanchez María Florencia ◽  
Guzman María Laura ◽  
Apas Ana Lidia ◽  
Alovero Fabiana del Lujan ◽  
Olivera María Eugenia
Keyword(s):  
Wound Healing ◽  
Ionic Exchange ◽  
Dual Release

scholarly journals Micelle-Coated, Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control

2018 ◽  
Vol 7 (11) ◽  
pp. 1800132 ◽  
Author(s):  
Victoria Albright ◽  
Meng Xu ◽  
Anbazhagan Palanisamy ◽  
Jun Cheng ◽  
Mary Stack ◽  
...  
Keyword(s):  
Wound Healing ◽  
Infection Control ◽  
Dual Release

scholarly journals Production of Chitosan/Hyaluronan Complex Nanofibers. Characterization and Physical Properties as a Function of the Composition

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2004
Author(s):  
Christian Enrique Garcia Garcia ◽  
Félix Armando Soltero Martínez ◽  
Frédéric Bossard ◽  
Marguerite Rinaudo
Keyword(s):  
Wound Healing ◽  
Polyelectrolyte Complex ◽  
The Body ◽  
Amide Bonds ◽  
Ph Values ◽  
Degree Of Swelling ◽  
Mechanical Performances ◽  
Optimized Conditions ◽  
First Time

In this work, optimized conditions for preparation of chitosan and hyaluronan polyelectrolyte complex are proposed. The objective was to produce new biomaterials being biocompatible and bioresorbable in the body as well as approaching the extracellular matrix (ECM) structure. These materials will be tested for chondrocyte development in tissue engineering and wound healing applications. Nanofibers made of the polyelectrolyte complex (PEC) were successfully manufactured by electrospinning, and casted films were used as a model for properties comparison. To our knowledge, it is the first time that stable chitosan/hyaluronan fibers are produced, which were observed to be long-lasting in buffer at pH~7.4. The role of thermal treatment at 120 °C for 4 h is examined to control the degree of swelling by crosslinking of the two polysaccharides by H-bonds and amide bonds formation. The properties of the materials are tested for different PEC compositions at different pH values, based on swelling and solubility degrees, diameters of nanofibers and mechanical performances. The influence of the solvent (acidic potential and composition) utilized to process biomaterials is also examined. Acid formic/water 50/50 v/v is observed to be the more appropriated solvent for the carried-out procedures.

Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing

2019 ◽  
Vol 11 (25) ◽  
pp. 22730-22744 ◽  
Author(s):  
Ming Shi ◽  
Hao Zhang ◽  
Ting Song ◽  
Xiaofang Liu ◽  
Yunfen Gao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Ph Responsive ◽  
Dual Release ◽  
Enhance Wound Healing

scholarly journals Alginate membrane dressing toughened by chitosan floccule to load antibacterial drugs for wound healing

2019 ◽  
Vol 79 ◽  
pp. 106039 ◽  
Author(s):  
Lian Xing ◽  
Ye Ma ◽  
Huaping Tan ◽  
Guoliang Yuan ◽  
Shengke Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Drugs

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

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