scholarly journals Micelle-Coated, Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control

2018 ◽  
Vol 7 (11) ◽  
pp. 1800132 ◽  
Author(s):  
Victoria Albright ◽  
Meng Xu ◽  
Anbazhagan Palanisamy ◽  
Jun Cheng ◽  
Mary Stack ◽  
...  
Keyword(s):  
Wound Healing ◽  
Infection Control ◽  
Dual Release

Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing

2021 ◽  
pp. 088532822199601
Author(s):  
Linying Shi ◽  
Fang Lin ◽  
Mou Zhou ◽  
Yanhui Li ◽  
Wendan Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Wound Dressings ◽  
Inflammatory Factors ◽  
Gelatin Microspheres ◽  
Infected Wounds ◽  
Dual Release

The ever-growing threats of bacterial infection and chronic wound healing have provoked an urgent need for novel antibacterial wound dressings. In this study, we developed a wound dressing for the treatment of infected wounds, which can reduce the inflammatory period (through the use of gentamycin sulfate (GS)) and enhance the granulation stage (through the addition of platelet-rich plasma (PRP)). Herein, the sustained antimicrobial CMC/GMs@GS/PRP wound dressings were developed by using gelatin microspheres (GMs) loading GS and PRP, covalent bonding to carboxymethyl chitosan (CMC). The prepared dressings exhibited high water uptake capability, appropriate porosity, excellent mechanical properties, sustain release of PRP and GS. Meanwhile, the wound dressing showed good biocompatibility and excellent antibacterial ability against Gram-negative and Gram-positive bacteria. Moreover, in vivo experiments further demonstrated that the prepared dressings could accelerate the healing process of E. coli and S. aureus-infected full-thickness wounds i n vivo, reepithelialization, collagen deposition and angiogenesis. In addition, the treatment of CMC/GMs@GS/PRP wound dressing could reduce bacterial count, inhibit pro-inflammatory factors (TNF-α, IL-1β and IL-6), and enhance anti-inflammatory factors (TGF-β1). The findings of this study suggested that biocompatible wound dressings with dual release of GS and PRP have great potential in the treatment of chronic and infected wounds.

Carboxymethyl cellulose-based materials for infection control and wound healing: A review

2020 ◽  
Vol 164 ◽  
pp. 963-975 ◽  
Author(s):  
Vimala Kanikireddy ◽  
Kokkarachedu Varaprasad ◽  
Tippabattini Jayaramudu ◽  
Chandrasekaran Karthikeyan ◽  
Rotimi Sadiku
Keyword(s):  
Wound Healing ◽  
Infection Control ◽  
Carboxymethyl Cellulose

Promoting coagulation and activating SMAD3 phosphorylation in wound healing via a dual-release thrombin-hydrogel

2020 ◽  
Vol 397 ◽  
pp. 125414
Author(s):  
Chongyang Wang ◽  
Tianyi Wu ◽  
Guangwang Liu ◽  
Ruoyu Cheng ◽  
Jian Fei ◽  
...  
Keyword(s):  
Wound Healing ◽  
Smad3 Phosphorylation ◽  
Dual Release

scholarly journals Nanomaterials in Wound Healing and Infection Control

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 473
Author(s):  
Ali Pormohammad ◽  
Nadia K. Monych ◽  
Sougata Ghosh ◽  
Diana L. Turner ◽  
Raymond J. Turner
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antibiotic Resistance ◽  
Infection Control ◽  
Persistent Infection ◽  
Wound Dressing ◽  
Healing Process ◽  
Wide Range ◽  
Different Types ◽  
Improve Wound Healing

Wounds continue to be a serious medical concern due to their increasing incidence from injuries, surgery, burns and chronic diseases such as diabetes. Delays in the healing process are influenced by infectious microbes, especially when they are in the biofilm form, which leads to a persistent infection. Biofilms are well known for their increased antibiotic resistance. Therefore, the development of novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm and wound healing properties are required. Nanomaterials (NM) have unique properties due to their size and very large surface area that leads to a wide range of applications. Several NMs have antimicrobial activity combined with wound regeneration features thus give them promising applicability to a variety of wound types. The idea of NM-based antibiotics has been around for a decade at least and there are many recent reviews of the use of nanomaterials as antimicrobials. However, far less attention has been given to exploring if these NMs actually improve wound healing outcomes. In this review, we present an overview of different types of nanomaterials explored specifically for wound healing properties combined with infection control.

SUSTAINED DUAL RELEASE OF CIPROFLOXACIN AND LIDOCAINE FROM IONIC EXCHANGE RESPONDING FILM BASED ON ALGINATE AND HYALURONATE FOR WOUND HEALING

2021 ◽  
pp. 105789
Author(s):  
Sanchez María Florencia ◽  
Guzman María Laura ◽  
Apas Ana Lidia ◽  
Alovero Fabiana del Lujan ◽  
Olivera María Eugenia
Keyword(s):  
Wound Healing ◽  
Ionic Exchange ◽  
Dual Release

Inflammation-responsive nanocapsules for the dual-release of antibacterial drugs

2020 ◽  
Vol 56 (84) ◽  
pp. 12725-12728
Author(s):  
Arjaree Jobdeedamrong ◽  
Man Theerasilp ◽  
Nattarat Wongsuwan ◽  
Norased Nasongkla ◽  
Daniel Crespy
Keyword(s):  
Wound Healing ◽  
Antibacterial Drugs ◽  
Ph Values ◽  
Dual Release ◽  
Silica Nanocapsules ◽  
Programmed Release

Inflammation-responsive silica nanocapsules allow a programmed release of dual antibiotics at different pH values, corresponding to various stages of wound healing.

Artificial Dermis and Autologous Platelet-Rich Plasma for Treatment of Refractory Wounds: A Clinical Study

2021 ◽  
pp. 153473462110507
Author(s):  
Yang Lv ◽  
Zhiguo Yang ◽  
Zenghong Chen ◽  
Juan Xie ◽  
Honghong Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Infection Control ◽  
Platelet Rich Plasma ◽  
Waiting Times ◽  
Complete Healing ◽  
Artificial Dermis ◽  
Autologous Platelet Rich Plasma ◽  
The Times ◽  
Clinical Dilemma ◽  
Autologous Platelet

Refractory wounds present a complex and serious clinical dilemma in plastic and reconstructive surgery. However, there are currently no standard guidelines for the treatment of refractory wounds. Artificial dermis (AD) has achieved some satisfactory results, but also has some limitations. Autologous platelet-rich plasma (PRP), as a cell-therapy material, was a valuable and safe treatment dressing for chronic non-healing wounds. This study aimed to evaluate the efficacies of artificial dermis (AD) with and without autologous platelet-rich plasma (PRP) in patients with refractory wounds. Sixteen patients with refractory wounds were randomly allocated to autologous PRP therapy combined with artificial dermis (PRP + AD [N = 8]) or an artificial dermis program only (AD [N = 8]). We compared the efficacies of the two methods in terms of times to wound healing, infection control, and AD vascularization, as well as hospitalization days and eventual clinical outcomes.13 patients achieved complete healing, including seven (87.5%) in the PRP + AD group and six (75.0%) in the AD group (P > .05). The times to wound healing, infection control, and AD vascularization, and hospitalization time after transfer were significantly shorter in the PRP + AD group compared with the AD group (P < .05). In conclusion, the combination of AD and PRP promoted refractory wound healing and shortened waiting times compared with simple dermal grafts.

Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing

2019 ◽  
Vol 11 (25) ◽  
pp. 22730-22744 ◽  
Author(s):  
Ming Shi ◽  
Hao Zhang ◽  
Ting Song ◽  
Xiaofang Liu ◽  
Yunfen Gao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Ph Responsive ◽  
Dual Release ◽  
Enhance Wound Healing
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