Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands

2020 ◽  
Vol 56 (39) ◽  
pp. 5227-5230
Author(s):  
Lu Ni ◽  
Takeshi Yamada ◽  
Kazuhiko Nakatani
Keyword(s):  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Double Stranded Dna

A new molecule containing an NCD moiety and a ruthenium complex was prepared, allowing the assembly of adjoining ruthenium complexes on single dsDNA.

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

2015 ◽  
Vol 51 (13) ◽  
pp. 2637-2640 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complex ◽  
Ruthenium Complexes

We have described the rational design of selenium-containing ruthenium complexes and their use as cancer radiosensitizers through regulating ROS-mediated pathways.

Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents

2020 ◽  
Vol 27 (22) ◽  
pp. 3735-3752 ◽  
Author(s):  
Si-Qi Zhang ◽  
Li-Hua Gao ◽  
Hua Zhao ◽  
Ke-Zhi Wang
Keyword(s):  
Anticancer Agents ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Anticancer Activities ◽  
Bridging Ligands ◽  
Metal Centers ◽  
Dna Binders ◽  
Structural Probes ◽  
Polynuclear Ruthenium Complexes

Ruthenium complexes have stood out by several mononuclear complexes which have entered into clinical trials, such as imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) and ([Ru(II)(4,4'-dimethyl-2,2'-bipyridine)2-(2(2'-,2'':5'',2'''-terthiophene)-imidazo[4,5-f] [1,10]phenanthroline)] 2+) (TLD-1433), opening a new avenue for developing promising ruthenium-based anticancer drugs alternative to Cisplatin. Polynuclear ruthenium complexes were reported to exhibit synergistic and/or complementary effects: the enhanced DNA structural recognition and DNA binding as well as in vitro anticancer activities. This review overviews some representative polynuclear ruthenium complexes acting as DNA structural probes, DNA binders and in vitro anticancer agents, which were developed during last decades. These complexes are reviewed according to two main categories of homo-polynuclear and hetero-polynuclear complexes, each of which is further clarified into the metal centers linked by rigid and flexible bridging ligands. The perspective, challenges and future efforts for investigations into these exciting complexes are pointed out or suggested.

A new designed hydrazine group-containing ruthenium complex used for catalytic hydrogenation of esters

2015 ◽  
Vol 51 (61) ◽  
pp. 12193-12196 ◽  
Author(s):  
Xuefeng Tan ◽  
Qingli Wang ◽  
Yuanhua Liu ◽  
Fangyuan Wang ◽  
Hui Lv ◽  
...  
Keyword(s):  
Catalytic Hydrogenation ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Excellent Performance

Hydrazine group-containing nitrogen–phosphine ruthenium complexes were synthesized and used for hydrogenation of esters, and excellent performance was observed (TON up to 17 200).

Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy

2019 ◽  
Vol 55 (67) ◽  
pp. 9904-9914 ◽  
Author(s):  
Jinggong Liu ◽  
Haoqiang Lai ◽  
Zushuang Xiong ◽  
Bolai Chen ◽  
Tianfeng Chen
Keyword(s):  
Targeted Therapy ◽  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Cancer Targeting ◽  
Bio Imaging

Herein, the functionalized Ruthenium complex applied for bio-imaging, photodynamic/photothermal therapy, precise targeted therapy and theranostics application have been discussed.

Mechanism Investigations of the Endo Cycloisomerization of Alkynols through Isolation and Characterization of Ruthenium Complexes from the Reactions of Alkynes with a Ruthenium Complex

2011 ◽  
Vol 30 (9) ◽  
pp. 2571-2580 ◽  
Author(s):  
Pei Nian Liu ◽  
Ting Bin Wen ◽  
Kun Dong Ju ◽  
Herman H.-Y. Sung ◽  
Ian D. Williams ◽  
...  
Keyword(s):  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Isolation And Characterization

Functionalization vs. degradation of 1,4-polybutadiene by ruthenium complex catalyzed reaction with vinylsilanes

2001 ◽  
Vol 79 (5-6) ◽  
pp. 775-779 ◽  
Author(s):  
Bogdan Marciniec ◽  
Ewa Malecka ◽  
Jacek Gulinski ◽  
Monika Grundwald-Wyspianska ◽  
Mariusz Lewandowski
Keyword(s):  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Ruthenium Catalysts ◽  
Cross Metathesis ◽  
Higher Temperature ◽  
Partial Degradation

Polybutadiene (I) containing 91% of 1,4-(cis-trans) units and 9% of 1,2-units in the presence of vinyltriethoxysilane (II) and ruthenium catalysts RuCl2(PPh3)3 (III), RuHCl(CO)(PPh3)3 (IV), and [RuCl2(CO)3]2 (V) at 100-130°C undergoes functionalization and (or) partial degradation as an effect of competitive silylative coupling of =C-H and cross-metathesis of I with II. Significant degradation of I occurs at lower temperatures (100-110°C) (particularly when the process is carried out in air), but exclusive functionalization of I is observed at higher temperature (120-130°C) regardless of the atmosphere (air or argon) used.Key words: functionalization, degradation, polybutadiene, ruthenium complexes.

Association of ruthenium complexes [Ru(bpy)3]2+ or [Ru(bpy)2(Mebpy-py)]2+ with Dawson polyanions α-[P2W18O62]6– or α2-[FeIII(H2O)P2W17O61]7–

2008 ◽  
Vol 86 (11) ◽  
pp. 1034-1043 ◽  
Author(s):  
L Ruhlmann ◽  
C Costa-Coquelard ◽  
J Hao ◽  
S Jiang ◽  
C He ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Steady State ◽  
Nmr Spectroscopy ◽  
Electrochemical Properties ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Association Constants ◽  
Luminescence Spectroscopy ◽  
Steady State Absorption

The formation of electrostatically linked complexes between [Ru(bpy)3]Cl2 or [Ru(bpy)2(Mebpy-py)](PF6)2 and (TBA)6α-[P2W18O62] or (TBA)5K2α2-[FeIII(H2O)P2W17O61] in solution were studied by steady-state absorption and luminescence spectroscopy. The stoichiometry and global association constants of the formed complexes were obtained by the Job method. The formed complexes were characterized by 1H and 31P NMR spectroscopy and their electrochemical properties compared to the precursor compounds were investigated by using the cyclic voltammetry method.Key words: electrochemistry, polyoxometalate, ruthenium complex, electrostatic complex.

scholarly journals Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

2016 ◽  
Vol 4 (3) ◽  
pp. 394-408 ◽  
Author(s):  
Matthew Dickerson ◽  
Brock Howerton ◽  
Younsoo Bae ◽  
Edith C. Glazer
Keyword(s):  
Biological Activity ◽  
Metal Complexes ◽  
Hydrophobic Interactions ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Release Rates ◽  
Electrostatic And Hydrophobic Interactions ◽  
Carrier Systems

Cross-linked polymeric nanoassemblies are potential carrier systems for cytotoxic ruthenium complexes, and exhibit a combination of electrostatic and hydrophobic interactions with the metal complexes that impact release rates, release percentages, and biological activity.

scholarly journals Oxidation-Induced Detachment of Ruthenoarene Units and Oxygen Insertion in Bis-Pd(II) Hexaphyrin π-Ruthenium Complexes

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2753
Author(s):  
Akito Nakai ◽  
Takayuki Tanaka ◽  
Atsuhiro Osuka
Keyword(s):  
1H Nmr ◽  
Ruthenium Complex ◽  
Theoretical Calculations ◽  
Ruthenium Complexes ◽  
Metal Complexation ◽  
Metal Coordination ◽  
Aerobic Conditions ◽  
Double Decker ◽  
Oxygen Insertion

Two types of new bis-Pd(II) hexaphyrin π-ruthenium complexes are reported. A double-decker bis-Pd(II) hexaphyrin π-ruthenium complex 4 was obtained by oxidation-induced detachment of a ruthenoarene unit from the triple-decker complex 3 and oxygen-inserted triple-decker bis-Pd(II) hexaphyrin π-ruthenium complex 6 was obtained upon treatment of bis-Pd(II) [26]hexaphyrin 5 with [RuCl2(p-cymene)]2 under aerobic conditions. Although π-metal complexation of porphyrinoids often results in decreased global aromaticity due to the enhancement of local 6π aromatic segments, distinct aromatic characters were indicated for 4 and 6 by 1H-NMR spectral and theoretical calculations. These results are accounted for in terms of possible resonance contributors of hexaphyrin di- and tetraanion ligands. Thus, π-metal coordination has been shown to be effective for modulation of the overall aromaticity.

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