scholarly journals Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

2016 ◽  
Vol 4 (3) ◽  
pp. 394-408 ◽  
Author(s):  
Matthew Dickerson ◽  
Brock Howerton ◽  
Younsoo Bae ◽  
Edith C. Glazer
Keyword(s):  
Biological Activity ◽  
Metal Complexes ◽  
Hydrophobic Interactions ◽  
Ruthenium Complex ◽  
Ruthenium Complexes ◽  
Release Rates ◽  
Electrostatic And Hydrophobic Interactions ◽  
Carrier Systems

Cross-linked polymeric nanoassemblies are potential carrier systems for cytotoxic ruthenium complexes, and exhibit a combination of electrostatic and hydrophobic interactions with the metal complexes that impact release rates, release percentages, and biological activity.

scholarly journals New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2288
Author(s):  
Ahmed Gaber ◽  
Moamen S. Refat ◽  
Arafa A.M. Belal ◽  
Ibrahim M. El-Deen ◽  
Nader Hassan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Analytical Data ◽  
Docking Study ◽  
Spectroscopic Techniques ◽  
Molecular Docking Study ◽  
Tetrahedral Geometry ◽  
Thiosemicarbazone Complexes

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

Structural characterization and biological activity of a new metal complexes based of Schiff base

2021 ◽  
Vol 330 ◽  
pp. 115522
Author(s):  
Ola A. El-Gammal ◽  
Farid Sh. Mohamed ◽  
Ghada N. Rezk ◽  
Ashraf A. El-Bindary
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Structural Characterization

Interaction of sulphone based reactive dyes with cationic surfactant: a spectroscopic and conductometric study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Misbah Iram ◽  
Hamadia Sultana ◽  
Muhammad Usman ◽  
Bazgha Ahmad ◽  
Nadia Akram ◽  
...  
Keyword(s):  
Strong Interaction ◽  
Cetyltrimethylammonium Bromide ◽  
Hydrophobic Interactions ◽  
Reactive Dyes ◽  
Micellar System ◽  
Palisade Layer ◽  
Micellar Systems ◽  
Gibbs Energies ◽  
Electrostatic And Hydrophobic Interactions ◽  
Conductometric Study

Abstract Interaction of sulphone based reactive dyes, designated as dye-1 and dye-2, with cationic micellar system of cetyltrimethylammonium bromide (CTAB), has been investigated by spectroscopic and conductometeric measurements. Efficiency of the selected micellar systems is assessed by the values of binding constant (K b ), partition coefficient (K x ) and respective Gibbs energies. Critical micelle concentration (CMC) of surfactant, electrostatic and hydrophobic interactions as well as polarity of the medium plays significant role in this phenomenon. The negative values of Gibbs energies of binding (∆G b ) and partition (∆G p ) predicts the feasibility and spontaneity of respective processes. Similarly negative values of ∆G m and ∆H m and positive values of ∆S m , calculated from conductometeric data, further, revealed the exothermicity, spontaneity and, thus, stability of system. The results, herein, have disclosed the strong interaction between dye and surfactant molecules. The dye-2 has been observed to be solubilized to greater extent, as compared to dye 1, due to strong interaction ith hydrophiles of CTAB and accommodation of its molecules in palisade layer of micelle closer to the micelle/water interface.

Metal complexes of polymers with amino acid residues. formation, stability and controlled biological activity

1990 ◽  
Vol 14 (1) ◽  
pp. 61-70 ◽  
Author(s):  
V.A. Lee ◽  
R.I. Musin ◽  
R.I. Tashmukhamedov ◽  
M.I. Shtilman ◽  
S.Sh. Rashidova
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Metal Complexes ◽  
Amino Acid Residues

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

2015 ◽  
Vol 51 (13) ◽  
pp. 2637-2640 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complex ◽  
Ruthenium Complexes

We have described the rational design of selenium-containing ruthenium complexes and their use as cancer radiosensitizers through regulating ROS-mediated pathways.

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