scholarly journals Biomaterial screening of protein coatings and peptide additives: towards a simple synthetic mimic of a complex natural coating for a bio-artificial kidney

2021 ◽  
Author(s):  
Ronald C. van Gaal ◽  
Annika F. Vrehen ◽  
Johnick F. van Sprang ◽  
Peter-Paul K. H. Fransen ◽  
Mark C. van Turnhout ◽  
...  
Keyword(s):  
Artificial Kidney ◽  
Protein Coating ◽  
Protein Coatings

A bis-urea biomaterial additive library was generated via a DoE approach. Comparison with a protein coating library revealed that simple catechol additives can replace a complex coating to create a living membrane for a bio-artificial kidney.

Essential environmental cues from the satellite cell niche: optimizing proliferation and differentiation

2009 ◽  
Vol 296 (6) ◽  
pp. C1338-C1345 ◽  
Author(s):  
K. J. M. Boonen ◽  
K. Y. Rosaria-Chak ◽  
F. P. T. Baaijens ◽  
D. W. J. van der Schaft ◽  
M. J. Post
Keyword(s):  
Regenerative Medicine ◽  
Progenitor Cells ◽  
Satellite Cell ◽  
Environmental Cues ◽  
Proliferation And Differentiation ◽  
Protein Coating ◽  
Satellite Cell Niche ◽  
Protein Coatings ◽  
Cell Niche

The use of muscle progenitor cells (MPCs) for regenerative medicine has been severely compromised by their decreased proliferative and differentiative capacity after being cultured in vitro. We hypothesized the loss of pivotal niche factors to be the cause. Therefore, we investigated the proliferative and differentiative response of passage 0 murine MPCs to varying substrate elasticities and protein coatings and found that proliferation was influenced only by elasticity, whereas differentiation was influenced by both elasticity and protein coating. A stiffness of 21 kPa optimally increased the proliferation of MPCs. Regarding differentiation, we demonstrated that fusion of MPCs into myotubes takes place regardless of elasticity. However, ongoing maturation with cross-striations and contractions occurred only on elasticities higher than 3 kPa. Furthermore, maturation was fastest on poly-d-lysine and laminin coatings.

Impact of protein coating strategies on the re-endothelialization of biological heart valve scaffolds

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
P Akhyari ◽  
H Ziegler ◽  
P Mambou ◽  
M Barth ◽  
S Hoffmann ◽  
...  
Keyword(s):  
Heart Valve ◽  
Protein Coating

METABOLIC SYNDROME IN DIALYSIS PATIENTS

2016 ◽  
pp. 7-11
Author(s):  
Vinh Phu Hoang ◽  
Tam Vo ◽  
Van Tien Le ◽  
Thi Hoai Huong Vo
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Artificial Kidney ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Average Value ◽  
The Metabolic Syndrome ◽  
End Stage

Objective: To review disorders elements of the metabolic syndrome in patients with end-stage chronic renal failure on dialysis cycle. Materials and methods: A cross sectional descriptive study of 85 patients including end-stage chronic renal failure in dialysis cycle from 5/2015 - 9/2016 at the Department of Artificial Kidney, Hue Central Hospital. Results: The prevalence of metabolic syndrome in dialysis patients was 37.65%. The prevalence of abdominal obesity was 30.6%; The prevalence of hypertension was 72.9%, the average value systolic blood pressure and diastolic blood pressure were 142.24 ± 27.53, 80.35 ± 12.48 mmHg; The prevalence of hyperglycemia was 28%, the average value blood glucose was 4.9 ± 1.19 mmol/l; The prevalence of triglyceride increase was 34.1%, the average value triglyceride was 1.59 ± 0.84 mmol/l. The prevalence of HDL-C increase was 47.1%, the average value HDL-C was 1.24 ± 0.33 mmol/l. Conclusion: The prevalence of metabolic syndrome in dialysis patients is very high, in which hypertension and HDL disturbances are the highest. Key words: chronic renal failure, dialysis, metabolic syndrome

scholarly journals The effect of ultrafiltration transmembrane permeation on the flow field in a surrogate system of an artificial kidney

2021 ◽  
Vol 2 ◽  
Author(s):  
Matilde De Pascale ◽  
Monica Faria ◽  
Cristiana Boi ◽  
Viriato Semiao ◽  
Maria Norberta de Pinho
Keyword(s):  
Pressure Drop ◽  
Artificial Kidney ◽  
Shear Stresses ◽  
Removal Rates ◽  
Permeable Membrane ◽  
Fluid Removal ◽  
Renal Replacement Therapies ◽  
Extracorporeal Blood Circulation ◽  
Conventional Hemodialysis ◽  
Upper Chamber

Abstract Renal Replacement Therapies generally associated to the Artificial Kidney (AK) are membrane-based treatments that assure the separation functions of the failing kidney in extracorporeal blood circulation. Their progress from conventional hemodialysis towards high-flux hemodialysis (HFHD) through the introduction of ultrafiltration membranes characterized by high convective permeation fluxes intensified the need of elucidating the effect of the membrane fluid removal rates on the increase of the potentially blood-traumatizing shear stresses developed adjacently to the membrane. The AK surrogate consisting of two-compartments separated by an ultrafiltration membrane is set to have water circulation in the upper chamber mimicking the blood flow rates and the membrane fluid removal rates typical of HFHD. Pressure drop mirrors the shear stresses quantification and the modification of the velocities profiles. The increase on pressure drop when comparing flows in slits with a permeable membrane and an impermeable wall is ca. 512% and 576% for $ \mathrm{CA}22/5\%{\mathrm{SiO}}_2 $ and $ \mathrm{CA}30/5\%{\mathrm{SiO}}_2 $ membranes, respectively.

On the Artificial Kidney XXV.

2009 ◽  
Vol 147 (2) ◽  
pp. 119-120 ◽  
Author(s):  
NILS ALWALL ◽  
ANDERS LUNDERQUIST
Keyword(s):  
Artificial Kidney
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