satellite cell niche
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2020 ◽  
Vol 34 (7) ◽  
pp. 8975-8989
Author(s):  
Joshua P. Nederveen ◽  
Sophie Joanisse ◽  
Aaron C. Q. Thomas ◽  
Tim Snijders ◽  
Katherine Manta ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Andreas Marg ◽  
Helena Escobar ◽  
Nikos Karaiskos ◽  
Stefanie A. Grunwald ◽  
Eric Metzler ◽  
...  

AbstractSkeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7, are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to utilize the regenerative potential of muscle stem cells for therapeutic purposes so far failed. We previously established the existence of human PAX7-positive cell colonies with high regenerative potential. We now identified PAX7-negative human muscle-derived cell colonies also positive for the myogenic markers desmin and MYF5. These include cells from a patient with a homozygous PAX7 c.86-1G > A mutation (PAX7null). Single cell and bulk transcriptome analysis show high intra- and inter-donor heterogeneity and reveal the endothelial cell marker CLEC14A to be highly expressed in PAX7null cells. All PAX7-negative cell populations, including PAX7null, form myofibers after transplantation into mice, and regenerate muscle after reinjury. Transplanted PAX7neg cells repopulate the satellite cell niche where they re-express PAX7, or, strikingly, CLEC14A. In conclusion, transplanted human cells do not depend on PAX7 for muscle regeneration.


2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Kamil Kowalski ◽  
Matthieu Dos Santos ◽  
Pascal Maire ◽  
Maria A. Ciemerych ◽  
Edyta Brzoska

Morphologie ◽  
2018 ◽  
Vol 102 (338) ◽  
pp. 153-154
Author(s):  
Zeynab Koumaiha ◽  
Baptiste Periou ◽  
Muriel Rigolet ◽  
Frédéric Relaix ◽  
Romain Gherardi ◽  
...  

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Aaron Thomas ◽  
Joshua Nederveen ◽  
Tim Snijders ◽  
Sophie Joanisse ◽  
Kirsten Bell ◽  
...  

FEBS Journal ◽  
2018 ◽  
Vol 285 (11) ◽  
pp. 1973-1984 ◽  
Author(s):  
Luiz Augusto Perandini ◽  
Patricia Chimin ◽  
Diego da Silva Lutkemeyer ◽  
Niels Olsen Saraiva Câmara

2018 ◽  
Vol 10 (3) ◽  
pp. 970-983 ◽  
Author(s):  
Valentina Flamini ◽  
Rachel S. Ghadiali ◽  
Philipp Antczak ◽  
Amy Rothwell ◽  
Jeremy E. Turnbull ◽  
...  

Thyroid ◽  
2017 ◽  
Vol 27 (10) ◽  
pp. 1316-1322 ◽  
Author(s):  
Anna Milanesi ◽  
Jang-Won Lee ◽  
An Yang ◽  
Yan-Yun Liu ◽  
Sargis Sedrakyan ◽  
...  

Author(s):  
Caroline E. Brun ◽  
Fabien P. Chevalier ◽  
Nicolas A. Dumont ◽  
Michael A. Rudnicki

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