A nanogel with passive targeting function and adjustable polyplex surface properties for efficient anti-tumor gene therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84445-84456 ◽  
Author(s):  
Haizhou Zhang ◽  
Qingbao Li ◽  
Yingying Zhang ◽  
Yu Xia ◽  
Liang Yun ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Surface Properties ◽  
Gene Transfection ◽  
Tumor Inhibition ◽  
Passive Targeting ◽  
Cellular Targeting ◽  
Tumor Gene Therapy ◽  
Dual Responsive ◽  
Tumor Gene

A dual responsive nanogel with tuneable polyplex properties was finely prepared. Its highin vivo/vitrogene transfection ability and passive cellular targeting function strongly promoted intratumor accumulation and tumor inhibition.

Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

2021 ◽  
Vol 9 (7) ◽  
pp. 2454-2466
Author(s):  
Yingying Liu ◽  
Yuli Zhou ◽  
Jinfeng Xu ◽  
Hui Luo ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Imaging ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Tumor Gene Therapy ◽  
Ultrasound Molecular Imaging ◽  
Tumor Gene

A novel dual-targeted cationic microbubbles help to improve gene transfection efficiency.

scholarly journals Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy

Oncogene ◽  
2004 ◽  
Vol 23 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Gianluca Bossi ◽  
Giuseppina Mazzaro ◽  
Alessandro Porrello ◽  
Marco Crescenzi ◽  
Silvia Soddu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
P53 Gene ◽  
Wild Type ◽  
Normal Cells ◽  
Tumor Gene Therapy ◽  
Wild Type P53 ◽  
Tumor Gene

Non-Viral Vectors for Gene Delivery

2018 ◽  
Vol 9 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Aparna Bansal ◽  
Himanshu
Keyword(s):  
Gene Therapy ◽  
Viral Vectors ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Expression System ◽  
Target Cells ◽  
Specific Expression ◽  
Naked Dna

Introduction: Gene therapy has emerged out as a promising therapeutic pave for the treatment of genetic and acquired diseases. Gene transfection into target cells using naked DNA is a simple and safe approach which has been further improved by combining vectors or gene carriers. Both viral and non-viral approaches have achieved a milestone to establish this technique, but non-viral approaches have attained a significant attention because of their favourable properties like less immunotoxicity and biosafety, easy to produce with versatile surface modifications, etc. Literature is rich in evidences which revealed that undoubtedly, non–viral vectors have acquired a unique place in gene therapy but still there are number of challenges which are to be overcome to increase their effectiveness and prove them ideal gene vectors. Conclusion: To date, tissue specific expression, long lasting gene expression system, enhanced gene transfection efficiency has been achieved with improvement in delivery methods using non-viral vectors. This review mainly summarizes the various physical and chemical methods for gene transfer in vitro and in vivo.

Covalent organic framework nanoparticles for anti-tumor gene therapy

2021 ◽  
Author(s):  
Kai Hao ◽  
Zhaopei Guo ◽  
Lin Lin ◽  
Pingjie Sun ◽  
Yanhui Li ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Covalent Organic Framework ◽  
Tumor Gene Therapy ◽  
Tumor Gene ◽  
Organic Framework

scholarly journals Advancement and prospects of tumor gene therapy

2011 ◽  
Vol 30 (3) ◽  
pp. 182-188 ◽  
Author(s):  
Chao Zhang ◽  
Qing-Tao Wang ◽  
He Liu ◽  
Zhen-Zhu Zhang ◽  
Wen-Lin Huang
Keyword(s):  
Gene Therapy ◽  
Tumor Gene Therapy ◽  
Tumor Gene

The research of nanoparticles as gene vector for tumor gene therapy

2014 ◽  
Vol 89 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Nian-feng Sun ◽  
Zhan-ao Liu ◽  
Wen-bai Huang ◽  
Ai-ling Tian ◽  
San-yuan Hu
Keyword(s):  
Gene Therapy ◽  
Gene Vector ◽  
Tumor Gene Therapy ◽  
Tumor Gene

scholarly journals The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9

2006 ◽  
Vol 80 (19) ◽  
pp. 9831-9836 ◽  
Author(s):  
Bassel Akache ◽  
Dirk Grimm ◽  
Kusum Pandey ◽  
Stephen R. Yant ◽  
Hui Xu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cultured Cells ◽  
Human Gene ◽  
Laminin Receptor ◽  
Transduction Efficiency ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Tumor Gene

ABSTRACT Adeno-associated virus serotype 8 (AAV8) is currently emerging as a powerful gene transfer vector, owing to its capability to efficiently transduce many different tissues in vivo. While this is believed to be in part due to its ability to uncoat more readily than other AAV serotypes such as AAV2, understanding all the processes behind AAV8 transduction is important for its application and optimal use in human gene therapy. Here, we provide the first report of a cellular receptor for AAV8, the 37/67-kDa laminin receptor (LamR). We document binding of LamR to AAV8 capsid proteins and intact virions in vitro and demonstrate its contribution to AAV8 transduction of cultured cells and mouse liver in vivo. We also show that LamR plays a role in transduction by three other closely related serotypes (AAV2, -3, and -9). Sequence and deletion analysis allowed us to map LamR binding to two protein subdomains predicted to be exposed on the AAV capsid exterior. Use of LamR, which is constitutively expressed in many clinically relevant tissues and is overexpressed in numerous cancers, provides a molecular explanation for AAV8's broad tissue tropism. Along with its robust transduction efficiency, our findings support the continued development of AAV8-based vectors for clinical applications in humans, especially for tumor gene therapy.

Biosilicified oncolytic adenovirus for cancer viral gene therapy

2020 ◽  
Vol 8 (19) ◽  
pp. 5317-5328 ◽  
Author(s):  
Hao Kong ◽  
Ruibo Zhao ◽  
Quan Zhang ◽  
Muhammed Zubair Iqbal ◽  
Jiaju Lu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Oncolytic Adenovirus ◽  
Viral Gene ◽  
Tumor Inhibition ◽  
Viral Gene Therapy

Biosilicified oncolytic adenovirus (OAs) significantly improved OAs distribution and tumor inhibition in vivo.

scholarly journals Analysis of the Immunologic Response Generated by Ad.IFN-β During Successful Intraperitoneal Tumor Gene Therapy

2002 ◽  
Vol 6 (2) ◽  
pp. 210-218 ◽  
Author(s):  
Makoto Odaka ◽  
Rainer Wiewrodt ◽  
Peter A DeLong ◽  
Tomoyuki Tanaka ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Immunologic Response ◽  
Tumor Gene Therapy ◽  
Tumor Gene
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