High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo

2021 ◽  
Author(s):  
Wonmin Choi ◽  
Claudia Battistella ◽  
Nathan C. Gianneschi
Keyword(s):  
Drug Release ◽  
High Efficiency ◽  
Rapid Release ◽  
Enzymatic Action ◽  
Micellar Nanoparticles

High efficiency encapsulation is coupled with drug release via a light switch followed by particle disassembly via enzymatic action.

Facile fabrication of positively-charged helical poly(phenyl isocyanide) modified multi-stimuli-responsive nanoassembly capable of high efficiency cell-penetrating, ratiometric fluorescence imaging, and rapid intracellular drug release

2018 ◽  
Vol 9 (31) ◽  
pp. 4233-4242 ◽  
Author(s):  
Wen-Ming Zhang ◽  
Jian Zhang ◽  
Zhu Qiao ◽  
Huan-Ying Liu ◽  
Zong-Quan Wu ◽  
...  
Keyword(s):  
Drug Release ◽  
High Efficiency ◽  
Polymeric Micelles ◽  
Helical Chain ◽  
Stimuli Responsive ◽  
Ratiometric Fluorescence ◽  
Rapid Release ◽  
Cell Penetrating ◽  
Facile Fabrication ◽  
Positively Charged

High efficiency cell-penetrating helical chain functionalized polymeric micelles capable of co-delivery of cargoes and rapid release were reported.

scholarly journals FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS

2017 ◽  
Vol 9 (4) ◽  
pp. 92
Author(s):  
Hrishav Das Purkayastha ◽  
Bipul Nath
Keyword(s):  
Drug Release ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Rapid Release ◽  
Weight Variation ◽  
Fast Disintegrating Tablet

Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magnesium stearate and compressed into tablets using the Cadmach single punch (round shaped, 8 mm thick) machine.Results: Physicals parameters of the prepared tablets like Hardness, Weight variation, Friability, thickness, drug content etc. found within the limits. The disintegration time of prepared ODTs was in the range of 45 to 55 seconds. In vitro dispersion time was found to be 22 to 52 seconds which may be attributed to faster uptake of water due to the porous structure formed by super disintegrants. Short disintegration and faster release of ibuprofen were observed with Cross carmellose sodium as compared to sodium starch glycollate.Conclusion: It is concluded that F3 offered the relatively rapid release of Ibuprofen when compared with other formulations. The increase in the concentrations of super disintegrants may lead to increase in the drug release. The formulation prepared with cross carmellose sodium was offered the relatively rapid release of Ibuprofen when compared with other concentrations of both the super disintegrant. 

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

scholarly journals DEVELOPMENT AND CHARACTERIZATION OF ORAL SWELLABLE RAPID RELEASE FILM WITH SUPERDISINTEGRANT-SURFACTANT

2021 ◽  
pp. 75-80
Author(s):  
NEHA IMTIAZ ◽  
SUTAPA BISWAS MAJEE ◽  
GOPA ROY BISWAS
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Diclofenac Sodium ◽  
Hydroxypropyl Methylcellulose ◽  
Tween 80 ◽  
Fickian Diffusion ◽  
Disintegration Time ◽  
Rapid Release ◽  
Oral Films

Objective: Oral disintegrating films consisting of hydrophilic polymer are designed to be quickly hydrated by saliva, adhere to the mucosa and disintegrate rapidly to release the drug. The aim of the present study was to prepare stable, flexible swellable rapid release oral films with hydroxypropyl methylcellulose E15 LV (HPMC) and polyvinyl alcohol (PVA) in different ratios. Guar gum was incorporated as the mucoadhesive agent. In order to achieve rapid disintegration of the film cross carmellose sodium (superdisintegrant) and surfactant like Tween 80 were added. The model drug used in the study was diclofenac sodium. Methods: Films were developed using HPMC E15 LV and PVA by solvent casting method and characterized for thickness, swelling index, disintegration time, folding endurance, drug content, and in vitro drug release pattern and kinetics. Results: The prepared swellable rapid release oral films were quite flexible and transparent with a smooth texture. The swelling index study confirmed that the films possessed the desired swelling property. Fastest disintegration was observed with the oral film containing HPMC: PVA in the ratio of 2:1, guar gum at 120 mg, 20% w/w crosscarmellose sodium and 4%w/w Tween 80. The swellable rapid release oral films were found to follow either Higuchi or Korsmeyer-Peppas model with drug release following either Fickian or non-Fickian diffusion. Maximum drug release of around 70% was observed from the above-mentioned film in 1hr in simulated salivary fluid. Conclusion: Therefore, swellable rapid release oral films with HPMC E15 LV: PVA, guar gum, croscarmellose sodium and Tween 80 demonstrated satisfactory swelling, rapid disintegration and improved drug release for oromucosal absorption.

FORMULATION AND EVALUATION OF SUMATRIPTAN SUCCINATE AND NAPROXEN SODIUM GASTRORETENTIVE (FLOATING) BILAYERED TABLETS

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 30-41
Author(s):  
K. Srinivasa Reddy ◽  
D. Vinay Kumar ◽  
CH. Lakshmi Bharath ◽  
P. Sri Ramya Madhuri
Keyword(s):  
Drug Release ◽  
Naproxen Sodium ◽  
Slow Release ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Direct Compression ◽  
Compression Method ◽  
Sumatriptan Succinate ◽  
Rapid Release ◽  
Gastro Retentive

The main aim of the present work was to formulate and evaluate sumatriptan succinate and naproxen sodium gastro retentive(floating) bilayered tablets. Floating bilayer tablets were formulated using direct compression method, it consist of two layers i.e IR layer containing Naproxen and floating CR layer containing sumatriptan. IR2 layer containing 2% concentration of Cross Povidone was found to be optimum and released 99.23% of naproxen in 45min. The optimized floating CR8 layer containing HPMC K 100M in 46% concentration showed 81.21% of drug release at the end of 12h. Among all formulations, IR2 & CR8 provided slow release of sumatriptan over 12h and rapid release of naproxen within 45 min, hence it is considered as an optimum bilayered formulation of sumatriptan and naproxen. The optimised formulation was fitted in the Kinetic models and it follows Korsmeyer-Peppas kinetics and the release mechanism was Case II non- fickian diffusion from these tablets.

scholarly journals Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 60 ◽  
Author(s):  
Ju Park ◽  
Hojun Seo ◽  
Da Kim ◽  
Ji Choi ◽  
Jin Son ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Hyperthermia Treatment ◽  
Anticancer Efficacy ◽  
Drug Molecules ◽  
Nir Light ◽  
Rapid Release ◽  
Triggered Drug Release

This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on–off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.

scholarly journals Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 92
Author(s):  
Chao Qin ◽  
Xiaofei Xin ◽  
Xue Pei ◽  
Lifang Yin ◽  
Wei He
Keyword(s):  
Cancer Cells ◽  
High Efficiency ◽  
Drug Loading ◽  
Water Soluble ◽  
Rapid Release ◽  
Water Soluble Drug ◽  
Anti Cancer ◽  
Poorly Water Soluble ◽  
Cancer Agent ◽  
Poorly Water Soluble Drug

Amorphous nanosuspensions (ANSs) enable rapid release and improved delivery of a poorly water-soluble drug; however, their preparation is challenging. Here, using hemoglobin (Hb) as a carrier, ANSs aggregated from paclitaxel (PTX)–Hb complexes were prepared to improve delivery of the hydrophobic anti-cancer agent. An affinity study demonstrated strong interaction between Hb and PTX. Importantly, the complexes could aggregate into <300 nm ANSs with high drug loading, which acidic condition facilitated their formation. Furthermore, the ANSs possessed improved cytotoxicity against cancer cells over the crystalline nanosuspensions. Taken together, ANSs aggregated from PTX–Hb complexes were developed, which could kill cancer cells with high efficiency.

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