Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

scholarly journals Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans

2020 ◽  
Author(s):  
Miriam Velasquez ◽  
Efwita Astria ◽  
Sarah Winkler ◽  
Weibin Liang ◽  
Heinz Amenitsch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Spatial Distribution ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tunable Release

In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.

scholarly journals Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans

2020 ◽  
Author(s):  
Miriam Velasquez ◽  
Efwita Astria ◽  
Sarah Winkler ◽  
Weibin Liang ◽  
Heinz Amenitsch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Spatial Distribution ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tunable Release

In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.

Bortezomib-catechol conjugated prodrug micelles: combining bone targeting and aryl boronate-based pH-responsive drug release for cancer bone-metastasis therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18387-18397 ◽  
Author(s):  
Jianhua Zhu ◽  
Qiang Huo ◽  
Ming Xu ◽  
Fen Yang ◽  
Yang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Metastasis ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Metastatic Tumors ◽  
Bone Targeting ◽  
Metastasis Therapy

The treatment of metastatic tumors is highly desirable in clinics, which has also increased the interest in the design of nanoscale drug delivery systems.

Formulation, Development and Characterization of Floating Beads of Diltiazem Hydrochloride

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anamika Saxena Saxena ◽  
Santosh Kitawat ◽  
Kalpesh Gaur ◽  
Virendra Singh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Repeated Administration ◽  
Alginate Beads ◽  
Delivery Systems ◽  
Sem Analysis ◽  
Formulation Development

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability and better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as copolymers along with sodium alginate.

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

pH responsive chitosan-coated microemulsions as drug delivery systems

2020 ◽  
pp. 1-12
Author(s):  
Daniela Díaz-Zepeda ◽  
René D. Peralta-Rodríguez ◽  
Bertha Puente-Urbina ◽  
Gladis Cortez-Mazatan ◽  
H. Iván Meléndez-Ortiz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive
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