scholarly journals Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 60 ◽  
Author(s):  
Ju Park ◽  
Hojun Seo ◽  
Da Kim ◽  
Ji Choi ◽  
Jin Son ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Hyperthermia Treatment ◽  
Anticancer Efficacy ◽  
Drug Molecules ◽  
Nir Light ◽  
Rapid Release ◽  
Triggered Drug Release

This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on–off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

scholarly journals Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 528 ◽  
Author(s):  
Ju Hyang Park ◽  
Da In Kim ◽  
Sang Gi Hong ◽  
Hojun Seo ◽  
Jongbok Kim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Synergistic Activity ◽  
Triggered Release ◽  
Hollow Nanoparticles ◽  
Anticancer Efficacy ◽  
Hollow Particles ◽  
On Demand ◽  
Drug Molecules ◽  
Nir Light ◽  
New System

A new system for the easy loading and NIR light-triggered release of drugs is introduced. It consists of poly(ε-caprolactone) (PCL) hollow nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings, which can enhance the connectivity between the interior and the exterior, enable the easy loading of drug molecules into the interior voids, and their successive sealing ensures a stable encapsulation of the drug. Upon exposure to an external NIR light irradiation, the photothermal agent generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, leading to the formation of nanopores on their shells, and consequently, the instant release of the encapsulated drug molecules through the pores. The synergistic activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.

Near-infrared laser-triggered drug release in tellurium nanosystem for simultaneous chemo-photothermal cancer therapy

2021 ◽  
Author(s):  
Linqi Duan ◽  
Ting Liu ◽  
Tianfeng Chen
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Cells ◽  
Clinical Application ◽  
Near Infrared ◽  
Infrared Laser ◽  
Normal Cells ◽  
Triggered Drug Release

Tumor cells can be selectively killed by the different tolerance of normal cells and tumor cells to temperature. However, the limited clinical application of PTT is mainly due to various...

scholarly journals Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ranran Zhang ◽  
Risheng Yao ◽  
Binbin Ding ◽  
Yuxin Shen ◽  
Shengwen Shui ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Uv Light ◽  
Nile Red ◽  
Controlled Drug Release ◽  
Hybrid Nanoparticles ◽  
Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Model Drug

Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymersin situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.

Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5269-5276 ◽  
Author(s):  
Qingjian Xing ◽  
Najun Li ◽  
Yang Jiao ◽  
Dongyun Chen ◽  
Jiaying Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Self Assembly ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
The Core ◽  
Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity

2015 ◽  
Vol 6 (21) ◽  
pp. 4030-4039 ◽  
Author(s):  
Gang Liu ◽  
Na Liu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Composite Nanoparticles ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand ◽  
Triggered Drug Release

Near infrared light-responsive polypeptide copolymer upconversion composite nanoparticles exhibited controllable drug release and triggered cytotoxicity useful for on-demand drug delivery and cancer therapy.

Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer

2015 ◽  
Vol 3 (7) ◽  
pp. 1147-1156 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Mingming Huang ◽  
Shanqing Lin ◽  
Dan Luo ◽  
...  
Keyword(s):  
Drug Release ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

Near-infrared (NIR) light-triggered drug release polymeric nanogels were fabricated based on host–guest interaction and were explored to encapsulate indocyanine green (ICG) and doxorubicin (DOX) for combined photothermal-chemotherapy of cancer.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

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