scholarly journals The unique potency of Cowpea mosaic virus (CPMV) in situ cancer vaccine

2020 ◽  
Vol 8 (19) ◽  
pp. 5489-5503
Author(s):  
Sourabh Shukla ◽  
Chao Wang ◽  
Veronique Beiss ◽  
Hui Cai ◽  
Torus Washington ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Mosaic Virus ◽  
Cancer Vaccine ◽  
Cowpea Mosaic Virus ◽  
Icosahedral Viruses ◽  
Viral Nanoparticle

Plant viral nanoparticle CPMV outperforms other icosahedral viruses as an in situ vaccine for cancer immunotherapy.

scholarly journals In situ vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy

2021 ◽  
Author(s):  
Paul L. Chariou ◽  
Veronique Beiss ◽  
Yifeng Ma ◽  
Nicole F. Steinmetz
Keyword(s):  
Cancer Immunotherapy ◽  
Mosaic Virus ◽  
Biomedical Applications ◽  
Cowpea Mosaic Virus ◽  
Development Pipeline ◽  
In Situ Vaccine

Cowpea mosaic virus (CPMV) is currently in the development pipeline for multiple biomedical applications, including cancer immunotherapy.

Cowpea mosaic virus (CPMV) as a carrier vehicle for antimalarial drugs, modification and application

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Rana A. K. Al-Refai’a
Keyword(s):  
Plasmodium Falciparum ◽  
Mosaic Virus ◽  
Biological Material ◽  
External Surface ◽  
Drug Carrier ◽  
Food Vacuole ◽  
Antimalarial Drugs ◽  
Chloroquine Resistance ◽  
Cowpea Mosaic Virus ◽  
Viral Nanoparticle

Globally more than 45% of the population is under the risk of malaria infection. In this presented work, three different compounds have been tested as anti-malarial agents with and without conjugation to the external surface of Cowpea mosaic virus (CPMV). The particle developed as a carrier of ferrocene (Fc) due to the resistance to commercially available antimalarial drugs. CPMV-Fc conjugate, in which 174 molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows the greatest inhibition toward proliferation of plasmodium falciparum compared to free ferrocene which has no activity as antimalarial agent. Fc also enhanced the activity of two different compounds of 4-aminochloroqunoline derivatives 3-((7chloroquinolin-4-yl) amino) propionic acid CQp and (7-chloroquinolin-4-yl) alanine CQ-ala, after its conjugation to CPMV-CQp and CPMV-CQ-ala in 82 and 134 molecules per particle respectively to give CPMV-CQ-p-Fc and CPMV-CQ-ala-Fc. The activity of each conjugated ferrocene has been evaluated with and without using biological material. In the case of biological material these compounds have been tested against both chloroquine sensitive strain 3D7 and chloroquine resistance strain Dd2 using the chloroquine as a standard antimalarial drug. The CPMV conjugate is targeted to the food vacuole parasite of the plasmodium falciparum cell, where the pH is dropped, drug carrier is degraded and the drug released.

scholarly journals Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

2018 ◽  
Vol 5 (5) ◽  
pp. 1700991 ◽  
Author(s):  
Anna E. Czapar ◽  
Brylee David B. Tiu ◽  
Frank A. Veliz ◽  
Jonathan K. Pokorski ◽  
Nicole F. Steinmetz
Keyword(s):  
Ovarian Cancer ◽  
Mosaic Virus ◽  
Slow Release ◽  
Vaccine Delivery ◽  
Cowpea Mosaic Virus ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
In Situ Vaccine

scholarly journals In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

2015 ◽  
Vol 11 (3) ◽  
pp. 295-303 ◽  
Author(s):  
P. H. Lizotte ◽  
A. M. Wen ◽  
M. R. Sheen ◽  
J. Fields ◽  
P. Rojanasopondist ◽  
...  
Keyword(s):  
Mosaic Virus ◽  
Metastatic Cancer ◽  
Cowpea Mosaic Virus

scholarly journals IMMU-73. GLIOMA IN SITU VACCINATION WITH COWPEA MOSAIC VIRUS NANOPARTICLES

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi138-vi138
Author(s):  
Amber Kerstetter-Fogle ◽  
Sourabh Shukla ◽  
Veronique Beiss ◽  
Peggy Harris ◽  
Andrew Sloan ◽  
...  
Keyword(s):  
Mosaic Virus ◽  
Cowpea Mosaic Virus

Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy

2021 ◽  
Vol 33 (7) ◽  
pp. 2007293 ◽  
Author(s):  
Yu Zhang ◽  
Sheng Ma ◽  
Xinming Liu ◽  
Yudi Xu ◽  
Jiayu Zhao ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cancer Vaccine

scholarly journals Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression

ACS Omega ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 3702-3707 ◽  
Author(s):  
Ravi Patel ◽  
Anna E. Czapar ◽  
Steven Fiering ◽  
Nancy L. Oleinick ◽  
Nicole F. Steinmetz
Keyword(s):  
Radiation Therapy ◽  
Mosaic Virus ◽  
Tumor Regression ◽  
Cowpea Mosaic Virus ◽  
Immune Mediated

scholarly journals Capsid Proteins of Cowpea Mosaic Virus Transiently Expressed in Protoplasts Form Virus-like Particles

Virology ◽  
1996 ◽  
Vol 224 (1) ◽  
pp. 352-355 ◽  
Author(s):  
Joan Wellink ◽  
Jan Verver ◽  
Jan Van Lent ◽  
A.Van Kammen
Keyword(s):  
Mosaic Virus ◽  
Capsid Proteins ◽  
Cowpea Mosaic Virus ◽  
Virus Like Particles
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