Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy

2021 ◽  
Vol 33 (7) ◽  
pp. 2007293 ◽  
Author(s):  
Yu Zhang ◽  
Sheng Ma ◽  
Xinming Liu ◽  
Yudi Xu ◽  
Jiayu Zhao ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cancer Vaccine

scholarly journals The unique potency of Cowpea mosaic virus (CPMV) in situ cancer vaccine

2020 ◽  
Vol 8 (19) ◽  
pp. 5489-5503
Author(s):  
Sourabh Shukla ◽  
Chao Wang ◽  
Veronique Beiss ◽  
Hui Cai ◽  
Torus Washington ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Mosaic Virus ◽  
Cancer Vaccine ◽  
Cowpea Mosaic Virus ◽  
Icosahedral Viruses ◽  
Viral Nanoparticle

Plant viral nanoparticle CPMV outperforms other icosahedral viruses as an in situ vaccine for cancer immunotherapy.

Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine

2021 ◽  
Vol 24 ◽  
pp. 101110
Author(s):  
Qiuyan Guo ◽  
Chufan Wang ◽  
Qiang Zhang ◽  
Keman Cheng ◽  
Wenjun Shan ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cancer Vaccine ◽  
Assisted Delivery ◽  
Microneedle Patch

Tumor Microenvironment-Triggered In-Situ Cancer Vaccines with Dual Immunogenic Cell Death Inductions for Elevated Antitumor and Antimetastatic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
High Specificity ◽  
The Body ◽  
Immunogenic Cell Death ◽  
Specific Antigens

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...

scholarly journals Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

2019 ◽  
Vol 31 (43) ◽  
pp. 1902626 ◽  
Author(s):  
Ravi B. Patel ◽  
Mingzhou Ye ◽  
Peter M. Carlson ◽  
Abigail Jaquish ◽  
Luke Zangl ◽  
...  
Keyword(s):  
Cancer Vaccine ◽  
Bacterial Membrane ◽  
Coated Nanoparticles

In Situ Self‐Assembly of Bispecific Peptide for Cancer Immunotherapy

2022 ◽  
Author(s):  
Man-Di Wang ◽  
Gan-Tian Lv ◽  
Hong-Wei An ◽  
Ni-Yuan Zhang ◽  
Hao Wang
Keyword(s):  
Cancer Immunotherapy ◽  
Self Assembly

Lipid Coated and Chlorin e6 Loaded Calcium Carbonate for Effective In Situ Immunotheraphy of Colorectal Cancer

2020 ◽  
Vol 16 (8) ◽  
pp. 1196-1204
Author(s):  
Wenxin Dai ◽  
Shaoquan Lu ◽  
Wangyuan Zeng ◽  
Dongwon Lee
Keyword(s):  
Colorectal Cancer ◽  
Calcium Carbonate ◽  
Cancer Vaccine ◽  
Inflammatory Responses ◽  
Chlorin E6 ◽  
Strong Immune Response ◽  
Tumor Associated Antigen

Cancer vaccine is well recognized as a novel but effective way for cancer immunotherapy. Especially, the role of dendritic cells (DCs) in antigen presentation properties is critical for the final performance of cancer vaccine. Herein, a lipid (Li) coated calcium carbonate (CC) vehicle (Li/CC) was employed to load chlorin e6 (Ce6) to serve as a potential in situ vaccine (Li/CC-Ce6) for effective immunotherapy of colorectal cancer. It was suggested that the loaded Ce6 within Li/CCCe6 can be activated under laser irradiation. The photodynamic therapy (PDT) of Ce6 was expected to produce reactive oxygen species (ROS) to cause cell death and expose tumor-associated antigen (TAA). In addition, the produced ROS can mimic the inflammatory responses for the recruitment of DC to initiate strong immune response cascade. Moreover, the recruitment of DC can recognize the exposed TAA to stimulate DC for effective vaccination in situ. Results from in vitro and in vivo assays demonstrated the strong ability of this platform to enhance DC vaccination, resulting in promising growth inhibition of both primary and distant tumors.

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