A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy

2020 ◽  
Vol 8 (15) ◽  
pp. 4067-4072 ◽  
Author(s):  
Xijian Liu ◽  
Minyi Zhang ◽  
Dawei Yan ◽  
Guoying Deng ◽  
Qi Wang ◽  
...  
Keyword(s):  
Combined Therapy ◽  
Anticancer Therapy ◽  
Ct Imaging ◽  
Anticancer Effect ◽  
Agent Based ◽  
Theranostic Agent

A smart theranostic agent based on Fe-HPPy@Au/DOX was fabricated, which could be used for CT imaging and PTT/chemotherapy/CDT combined therapy, demonstrating an excellent anticancer effect.

A novel theranostic agent based on porous bismuth nanosphere for CT imaging-guided combined chemo-photothermal therapy and radiotherapy

2018 ◽  
Vol 6 (42) ◽  
pp. 6788-6795 ◽  
Author(s):  
Guochang Ma ◽  
Xijian Liu ◽  
Guoying Deng ◽  
Haikuan Yuan ◽  
Qiugen Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Ct Imaging ◽  
Combined Chemotherapy ◽  
Agent Based ◽  
Theranostic Agent

A novel theranostic agent based on porous bismuth (pBi) nanospheres was developed for tumor imaging and combined chemotherapy, photothermal therapy and radiotherapy.

scholarly journals Comparison of Simple Models of Periodic Protocols for Combined Anticancer Therapy

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Marzena Dołbniak ◽  
Andrzej Świerniak
Keyword(s):  
Differential Equation ◽  
Ordinary Differential Equation ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Combined Therapy ◽  
Anticancer Therapy ◽  
Cytostatic Drugs ◽  
Ode Models ◽  
Biological Aspects ◽  
Simple Models

Several simple ordinary differential equation (ODE) models of tumor growth taking into account the development of its vascular network are discussed. Different biological aspects are considered from the simplest model of Hahnfeldt et al. proposed in 1999 to a model which includes drug resistance of cancer cells to chemotherapy. Some of these models can be used in clinical oncology to optimize antiangiogenic and cytostatic drugs delivery so as to ensure maximum efficacy. Simple models of continuous and periodic protocols of combined therapy are implemented. Discussion on the dynamics of the models and their complexity is presented.

One small molecule as a theranostic agent: naphthalimide dye for subcellular fluorescence localization and photodynamic therapy in vivo

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1171-1175 ◽  
Author(s):  
Lei Zhang ◽  
Kecheng Lei ◽  
Jingwen Zhang ◽  
Wenlin Song ◽  
Yuanhong Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Small Molecule ◽  
Single Molecule ◽  
Therapeutic Treatment ◽  
Agent Based ◽  
Theranostic Agent ◽  
Bright Fluorescence ◽  
Naphthalimide Dye

A small single-molecule theranostic agent based on naphthalimide was developed, which possessed both bright fluorescence imaging and effective photodynamic therapeutic treatment.

scholarly journals Drug Repurposing of Asparaginase and Vitamin C Targeting Glutamine Synthetase Improves Anticancer Effect in Metastatic Castration-resistant Prostate Cancer

2022 ◽  
Author(s):  
Zhoulei Li ◽  
Wanqing Shen ◽  
Zhifeng Chen ◽  
Gang Yuan ◽  
Peng He ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Glutamine Synthetase ◽  
Vitamin C ◽  
Combined Therapy ◽  
Drug Repurposing ◽  
Castration Resistant Prostate Cancer ◽  
Anticancer Effect ◽  
18F Fdg

Abstract Background: Although in North America or Europe early dignosis of prostate cancer could sucessfully improves the therapeutic outcome. However, about 70-80% of patients still suffer from metastatic castration-resistant prostate cancer (mCRPC), because of the disproportionate medical care in China. Lutetium-177 (Lu-177) or Radium-223 (Ra-223) has been suggested as the most effective therapy for mCRPC. Unfortunately, they are either not been approved in a few countries or too expensive for patients with the financial issue. Drug repurposing has been recognized as a cost-effective and relatively low-risk alternative, gains a lot interesting recently. In this study, we explored the combined treatment with asparaginase (ASNase) and/or vitamin Cas an alternative therapeutic option for mCRPC management.Methods: Prostate cancer cell lines PC3 and DU145 were used to observe the therapeutic effect of ASNase and/or vitamin C on mCRPC in vitro and in vivo. Change of cell proliferation, cell death as well as expression of glutamine synthetase eunder different treatment conditions were detected to analyzed anticancer effect of combined therapy with ASNase and vitamin C on mCRPC. Intracellular oxidation was also observed with NADPH and NADP+ assay. Male BALB/c nude mice bearing prostate carcinoma xenografts (PC3 or DU145) were used to assess treatment response to vitamin C with or without ASNase through tumor growth, small animal PET/CT scans as well as Immunohistochemistry in vivo.Results: Our in vitro studies demonstrate that ASNase synergizes with vitamin C targeting expression of glutamine synthetase enhances redox imbalance and induces anticancer effect in mCRPC cells through regulation the glutamine synthetase (GS) expression. In vivo, combination of ASnase and vitamin C could provide a significant better therapeutic outcome in comparison with controls or single treated mice. 18F-FDG PET imaging illustrated that the treatment with combined therapy could significantly reduce the 18F-FDG uptake in tumor.Conclusions: In this current study, we suggest that ASNase combined with vitamin C could be as a cost-effective strategy to manage mCRPC.18F-FDG PET/CT imaging could indicate the therapeutic response of treatment for mCRPC.

Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy

Small ◽  
2018 ◽  
Vol 14 (14) ◽  
pp. 1703789 ◽  
Author(s):  
Zhao-Hua Miao ◽  
Lan-Xiang Lv ◽  
Kai Li ◽  
Pei-Ying Liu ◽  
Zhenglin Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Liquid Exfoliation ◽  
Theranostic Agent

scholarly journals Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors.

2009 ◽  
Vol 56 (1) ◽  
Author(s):  
Iwona Mitrus ◽  
Aleksander Sochanik ◽  
Tomasz Cichoń ◽  
Stanisław Szala
Keyword(s):  
Combination Therapy ◽  
Liposomal Doxorubicin ◽  
Combined Therapy ◽  
Antineoplastic Agent ◽  
Anticancer Therapy ◽  
Experimental Tumors ◽  
Combretastatin A4 ◽  
Therapeutic Results ◽  
Inhibition Of Tumor Growth ◽  
Tumor Blood Vessels

The study aimed to check the effectiveness of anticancer therapy combining a vascular-disruptive drug (combretastatin phosphate, CA4P) and a liposomal formulation of a chemotherapeutic (doxorubicin). CA4P was synthesized in our laboratory according to a previously described procedure. The antivascular drug and long-circulating doxorubicin-loaded liposomes were used to treat B16-F10 murine melanoma experimental tumors. Seventy-four hours after drug administration, a decrease in the number of tumor blood vessels was apparent and necrotic areas within tumors were visible. Combination therapy consisting of alternate administrations of CA4P and liposomal doxorubicin yielded greater inhibition of tumor growth than monotherapies alone. The best therapeutic results were obtained with the antivascular drug administered intratumorally every second day at 50 mg/kg body mass. In the case of combined therapy, the best results were obtained when the vascular-disruptive agent (CA4P) and the antineoplastic agent (liposomal doxorubicin) were administered in alternation.

Multifunctional Bismuth Nanoparticles as Theranostic Agent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy

2018 ◽  
Vol 1 (2) ◽  
pp. 820-830 ◽  
Author(s):  
Chunyu Yang ◽  
Chongshen Guo ◽  
Wei Guo ◽  
Xiaole Zhao ◽  
Shaoqin Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Bismuth Nanoparticles ◽  
Theranostic Agent ◽  
Nir Laser

scholarly journals Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yingying Zhang ◽  
Yongxue Zhang ◽  
Lianglan Yin ◽  
Xiaotian Xia ◽  
Fan Hu ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Biomedical Application ◽  
Infrared Region ◽  
Ct Imaging ◽  
Targeted Imaging ◽  
Coupling Reactions ◽  
Theranostic Agent ◽  
Iodine 131

Introduction.Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrinαvβ3-expressing tumors.Methods.HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions. The nanoconjugate was characterized, and131I was directly tagged on the surface of GNRs via AuI bonds for SPECT/CT imaging. We preliminarily studied the characteristics of the probe and its feasibility for tumor-targeting SPECT/CT imaging.Results.The[131I]GNR-PEG-cRGD probe was prepared in a simple and rapid manner and was stable in both PBS and fetal bovine serum. It targeted selectively and could be taken up by tumor cells mainly via integrinαvβ3-receptor-mediated endocytosis. In vivo imaging, biodistribution, and autoradiography results showed evident tumor uptake in integrinαvβ3-expressing tumors.Conclusions.These promising results showed that this smart nanoprobe can be used for angiogenesis-targeted SPECT/CT imaging. Furthermore, the nanoprobe possesses a remarkable capacity for highly efficient photothermal conversion in the near-infrared region, suggesting its potential as a multifunctional theranostic agent.

scholarly journals Protein-based photothermal theranostics for imaging-guided cancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16330-16336 ◽  
Author(s):  
Pengfei Rong ◽  
Peng Huang ◽  
Zhiguo Liu ◽  
Jing Lin ◽  
Albert Jin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Multimodality Imaging ◽  
Tumor Ablation ◽  
Agent Based ◽  
Theranostic Agent

We developed a clinically translatable photothermal theranostic agent based on a heptamethine dye, CySCOOH conjugated HSA, for multimodality imaging and photothermal tumor ablation.

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