Multifunctional Bismuth Nanoparticles as Theranostic Agent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy

2018 ◽  
Vol 1 (2) ◽  
pp. 820-830 ◽  
Author(s):  
Chunyu Yang ◽  
Chongshen Guo ◽  
Wei Guo ◽  
Xiaole Zhao ◽  
Shaoqin Liu ◽  
...  
2018 ◽  
Vol 19 (01) ◽  
pp. 1850043 ◽  
Author(s):  
Samireh Badrigilan ◽  
Behrouz Shaabani ◽  
Nahideh Ghareh Aghaji ◽  
Asghar Mesbahi

By integrating high-performance CT imaging and photothermal therapy (PTT) into one nanoprobe, an effective theranostic can be achieved for clinical cancer treatment. In this study, the graphene quantum dots (GQDs)-coated bismuth (Bi) nanoparticle (NP) as a theranostic nanoprobe is synthesized and its capabilities for computed tomography (CT) imaging and PTT are investigated. Such nanotheranostic exhibits good physiological dispersity with satisfactory blood compatibility and cytotoxicity. Most importantly, the GQDs-Bi NPs offer strong and steady absorbance profile in NIR region with excellent photostability, which can remarkably convert photo-to-thermal with the photothermal efficiency of 30.0%. Thanks to the powerful PTT effect, co-delivery of GQDs-Bi NPs/NIR laser can effectively induce HeLa cells death in vitro. Cooperatively, NPs hold X-ray attenuation coefficient for high-contrast CT imaging with the corresponding CT improvement efficacy as high as 32.7[Formula: see text]HU[Formula: see text]mg[Formula: see text]. The obtained results highlight the potential of GQDs-Bi NPs as a successful theranostic nanoagent for CT imaging and cancer photothermal therapy.


Small ◽  
2018 ◽  
Vol 14 (14) ◽  
pp. 1703789 ◽  
Author(s):  
Zhao-Hua Miao ◽  
Lan-Xiang Lv ◽  
Kai Li ◽  
Pei-Ying Liu ◽  
Zhenglin Li ◽  
...  

2018 ◽  
Vol 6 (42) ◽  
pp. 6788-6795 ◽  
Author(s):  
Guochang Ma ◽  
Xijian Liu ◽  
Guoying Deng ◽  
Haikuan Yuan ◽  
Qiugen Wang ◽  
...  

A novel theranostic agent based on porous bismuth (pBi) nanospheres was developed for tumor imaging and combined chemotherapy, photothermal therapy and radiotherapy.


RSC Advances ◽  
2016 ◽  
Vol 6 (39) ◽  
pp. 33083-33091 ◽  
Author(s):  
Chunyang Li ◽  
Zhijia Liu ◽  
Ping Yao

The nanoparticles improved tumor CT imaging and cured tumors after injection of the nanoparticles followed by NIR laser irradiation.


2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  

2018 ◽  
Vol 5 (12) ◽  
pp. 125401 ◽  
Author(s):  
Esmat Ramezanzadeh ◽  
Kayvan Sadri ◽  
Mahdi Momennezhad ◽  
Elham Dolat ◽  
Ameneh Sazgarnia

2019 ◽  
Vol 17 ◽  
pp. 619-627 ◽  
Author(s):  
Shu-Ting Lu ◽  
Dan Xu ◽  
Ru-Fang Liao ◽  
Jia-Zhen Luo ◽  
Yu-Hang Liu ◽  
...  

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