scholarly journals Protein-based photothermal theranostics for imaging-guided cancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16330-16336 ◽  
Author(s):  
Pengfei Rong ◽  
Peng Huang ◽  
Zhiguo Liu ◽  
Jing Lin ◽  
Albert Jin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Multimodality Imaging ◽  
Tumor Ablation ◽  
Agent Based ◽  
Theranostic Agent

We developed a clinically translatable photothermal theranostic agent based on a heptamethine dye, CySCOOH conjugated HSA, for multimodality imaging and photothermal tumor ablation.

Hybrid Theranostic Microbubbles for Ultrasound/Photoacoustic Imaging Guided Starvation/Low-Temperature Photothermal/Hypoxia-Activated Synergistic Cancer Therapy

2021 ◽  
Author(s):  
Feng Tian ◽  
Xingjian Zhong ◽  
Junkai Zhao ◽  
Yutian Gu ◽  
Yadi Fan ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Low Temperature ◽  
Photoacoustic Imaging ◽  
Multimodality Imaging ◽  
High Contrast ◽  
Theranostic Agent ◽  
Systemic Side Effects ◽  
Tumor Retention

Constructing a theranostic agent for high-contrast multimodality imaging-guided synergistic therapy with long-term tumor retention and minimum systemic side effects still remains a major challenge. Herein, a hybrid microbubble-based theranostic platform...

scholarly journals A theranostic agent for cancer therapy and imaging in the second near-infrared window

Nano Research ◽  
2018 ◽  
Vol 12 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Zhuoran Ma ◽  
Hao Wan ◽  
Weizhi Wang ◽  
Xiaodong Zhang ◽  
Takaaki Uno ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Theranostic Agent ◽  
Infrared Window

scholarly journals A narrow-bandgap benzobisthiadiazole derivative with high near-infrared photothermal conversion efficiency and robust photostability for cancer therapy

2015 ◽  
Vol 51 (20) ◽  
pp. 4223-4226 ◽  
Author(s):  
Shuo Huang ◽  
Ravi Kumar Kannadorai ◽  
Yuan Chen ◽  
Quan Liu ◽  
Mingfeng Wang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Conversion Efficiency ◽  
Near Infrared ◽  
Therapeutic Agent ◽  
Infrared Region ◽  
Strong Absorption ◽  
Agent Based ◽  
Narrow Bandgap ◽  
Near Infrared Region

A novel photothermal therapeutic agent based on a narrow-bandgap benzobisthiadiazole derivative shows strong absorption in the near-infrared region, high photothermal efficiency and robust photostability for treatment of cancer cells.

One small molecule as a theranostic agent: naphthalimide dye for subcellular fluorescence localization and photodynamic therapy in vivo

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1171-1175 ◽  
Author(s):  
Lei Zhang ◽  
Kecheng Lei ◽  
Jingwen Zhang ◽  
Wenlin Song ◽  
Yuanhong Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Small Molecule ◽  
Single Molecule ◽  
Therapeutic Treatment ◽  
Agent Based ◽  
Theranostic Agent ◽  
Bright Fluorescence ◽  
Naphthalimide Dye

A small single-molecule theranostic agent based on naphthalimide was developed, which possessed both bright fluorescence imaging and effective photodynamic therapeutic treatment.

A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy

2020 ◽  
Vol 8 (15) ◽  
pp. 4067-4072 ◽  
Author(s):  
Xijian Liu ◽  
Minyi Zhang ◽  
Dawei Yan ◽  
Guoying Deng ◽  
Qi Wang ◽  
...  
Keyword(s):  
Combined Therapy ◽  
Anticancer Therapy ◽  
Ct Imaging ◽  
Anticancer Effect ◽  
Agent Based ◽  
Theranostic Agent

A smart theranostic agent based on Fe-HPPy@Au/DOX was fabricated, which could be used for CT imaging and PTT/chemotherapy/CDT combined therapy, demonstrating an excellent anticancer effect.

Viewing the Emphasis on State-of-the-Art Magnetic Nanoparticles: Synthesis, Physical Properties, and Applications in Cancer Theranostics

2019 ◽  
Vol 25 (13) ◽  
pp. 1505-1523 ◽  
Author(s):  
Satyavani Kaliamurthi ◽  
Ayse Demir-Korkmaz ◽  
Gurudeeban Selvaraj ◽  
Emine Gokce-Polat ◽  
Yong-Kai Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Early Diagnosis ◽  
Imaging System ◽  
Multimodality Imaging ◽  
Imaging Techniques ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Clinical Experiments

Cancer-related mortality is a leading cause of death among both men and women around the world. Target-specific therapeutic drugs, early diagnosis, and treatment are crucial to reducing the mortality rate. One of the recent trends in modern medicine is “Theranostics,” a combination of therapeutics and diagnosis. Extensive interest in magnetic nanoparticles (MNPs) and ultrasmall superparamagnetic iron oxide nanoparticles (NPs) has been increasing due to their biocompatibility, superparamagnetism, less-toxicity, enhanced programmed cell death, and auto-phagocytosis on cancer cells. MNPs act as a multifunctional, noninvasive, ligand conjugated nano-imaging vehicle in targeted drug delivery and diagnosis. In this review, we primarily discuss the significance of the crystal structure, magnetic properties, and the most common method for synthesis of the smaller sized MNPs and their limitations. Next, the recent applications of MNPs in cancer therapy and theranostics are discussed, with certain preclinical and clinical experiments. The focus is on implementation and understanding of the mechanism of action of MNPs in cancer therapy through passive and active targeting drug delivery (magnetic drug targeting and targeting ligand conjugated MNPs). In addition, the theranostic application of MNPs with a dual and multimodal imaging system for early diagnosis and treatment of various cancer types including breast, cervical, glioblastoma, and lung cancer is reviewed. In the near future, the theranostic potential of MNPs with multimodality imaging techniques may enhance the acuity of personalized medicine in the diagnosis and treatment of individual patients.

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