scholarly journals XVIII.—On γ-phenoxy-derivatives of malonic acid and acetic acid, and various compounds used in the synthesis of these acids

1896 ◽  
Vol 69 (0) ◽  
pp. 161-175 ◽  
Author(s):  
William Henry Bentley ◽  
Edward Haworth ◽  
William Henry Perkin
1982 ◽  
Vol 47 (5) ◽  
pp. 1382-1391 ◽  
Author(s):  
Jiří Jílek ◽  
Josef Pomykáček ◽  
Jiřina Metyšová ◽  
Miroslav Protiva

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.


1978 ◽  
Vol 9 (34) ◽  
Author(s):  
A. P. KARISHIN ◽  
A. A. PECHKA ◽  
N. F. GRINEVA
Keyword(s):  

ChemInform ◽  
2010 ◽  
Vol 25 (7) ◽  
pp. no-no
Author(s):  
R. WINTER ◽  
G. L. GARD ◽  
R. MEWS ◽  
M. NOLTEMEYER

2005 ◽  
Vol 2005 (10) ◽  
pp. 640-642 ◽  
Author(s):  
Ying Liu ◽  
Liang Zhao ◽  
Liang Liu ◽  
Lin-Yi Wei ◽  
Lu-Hua Lai

Amino acid derivatives of a modified indole-3-acetic acid have been synthesised. Fourteen new dipeptide-like compounds 3–4 were obtained and their structures were elucidated based on the IR, 1H NMR, MS spectra.


ChemInform ◽  
2010 ◽  
Vol 32 (51) ◽  
pp. no-no
Author(s):  
S. S. Koval'skaya ◽  
N. G. Kozlov
Keyword(s):  

Synlett ◽  
2015 ◽  
Vol 26 (10) ◽  
pp. 1361-1364
Author(s):  
Tammar Ali ◽  
Thorsten Heidelberg ◽  
Rusnah Hussen
Keyword(s):  

2006 ◽  
Vol 14 (12) ◽  
pp. 4101-4109 ◽  
Author(s):  
Silvia Gobbi ◽  
Federica Belluti ◽  
Alessandra Bisi ◽  
Lorna Piazzi ◽  
Angela Rampa ◽  
...  

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