New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-α and NO production by human immune cells

2006 ◽  
Vol 14 (12) ◽  
pp. 4101-4109 ◽  
Author(s):  
Silvia Gobbi ◽  
Federica Belluti ◽  
Alessandra Bisi ◽  
Lorna Piazzi ◽  
Angela Rampa ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Immune Cells ◽  
Acid Synthesis ◽  
No Production ◽  
Pharmacological Profile ◽  
Tnf Α ◽  
Human Immune ◽  
Derivatives Of

ChemInform Abstract: New Derivatives of 2-(3,5-Dioxo-4-azatricyclo [5.2.1.02,6-endo]dec-8-en-4-yl)acetic Acid. Synthesis and Reactivity.

ChemInform ◽  
2008 ◽  
Vol 39 (10) ◽  
Author(s):  
I. N. Tarabara ◽  
Ya. S. Bondarenko ◽  
A. A. Zhurakovskii ◽  
L. I. Kas'yan
Keyword(s):  
Acetic Acid ◽  
Acid Synthesis ◽  
Derivatives Of

Madimadi, Korean folk medicine, blocks TNF-α, IL-1β, and IL-8 production by activated human immune cells

Cytokine ◽  
2004 ◽  
Vol 25 (4) ◽  
pp. 179-186 ◽  
Author(s):  
Mi-Sun Kim ◽  
Jin-Mu Yi ◽  
Sung Hoon Kim ◽  
Seung-Heon Hong ◽  
Hyung Min Kim
Keyword(s):  
Immune Cells ◽  
Folk Medicine ◽  
Tnf Α ◽  
Korean Folk Medicine ◽  
Human Immune

scholarly journals Particle size and activation threshold: a new dimension of danger signaling

Blood ◽  
2010 ◽  
Vol 115 (22) ◽  
pp. 4533-4541 ◽  
Author(s):  
Lorna Rettig ◽  
Sebastian P. Haen ◽  
Anne Greet Bittermann ◽  
Lotta von Boehmer ◽  
Alessandra Curioni ◽  
...  
Keyword(s):  
Immune Cells ◽  
Interferon Α ◽  
Innate Response ◽  
Activation Threshold ◽  
Tnf Α ◽  
Nanometric Particles ◽  
Human Immune ◽  
Factor Α ◽  
Molecular Patterns ◽  
Necrosis Factor

Abstract Previous studies have shown that single-stranded RNA (ssRNA) mixed with protamine forms particles and activates immune cells through Toll-like receptors (TLRs). We have found that the size of protamine-RNA particles generated depends on the electrolyte content when mixing the 2 components. Moreover, we have evidenced that (1) nanometric particles induce production of interferon-α, whereas (2) micrometric particles mainly induce production of tumor necrosis factor-α (TNF-α) in human immune cells. We found that the mechanisms underlying these observations are (1) nanoparticles but not microparticles are selectively phagocytosed by plasmacytoid dendritic cells (pDCs), which produce interferon-α and (2) monocytes that produce TNF-α have a higher activation threshold than that of pDCs. Thus, at the same time as sensing pathogen-associated molecular patterns such as ssRNA, the immune system distinguishes the size of the associated structure in such a way as to trigger the adapted antivirus (nanometric) or antibacterial/antifungal (micrometric) immune response. Our results introduce a new dimension in danger signaling—how size qualitatively affects innate response.

New derivatives of 2-(3,5-Dioxo-4-azatricyclo[5.2.1.02,6-endo ]dec-8-en-4-yl)acetic acid. Synthesis and reactivity

2007 ◽  
Vol 43 (9) ◽  
pp. 1297-1304 ◽  
Author(s):  
I. N. Tarabara ◽  
Ya. S. Bondarenko ◽  
A. A. Zhurakovskii ◽  
L. I. Kas’yan
Keyword(s):  
Acetic Acid ◽  
Acid Synthesis ◽  
Derivatives Of

Synthesis of 1,2,4-triazine-3,5(2H,4H)-diones containing electronegative substituents in position 6

1983 ◽  
Vol 48 (9) ◽  
pp. 2676-2681 ◽  
Author(s):  
Jiří Farkaš
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Nitro Compound ◽  
Trifluoroacetic Acid ◽  
Acid Synthesis ◽  
Amino Derivative ◽  
Effect Of Substituents ◽  
Fluoro Derivative ◽  
Cuprous Cyanide ◽  
Derivatives Of

Reaction of fluorine with 1,2,4-triazine-3,5(2H,4H)-dione (I) in acetic acid afforded the 6-fluoro derivative II in low yield. The 6-nitro compound III was prepared by oxidation of the 6-amino derivative of compound I with hydrogen peroxide in trifluoroacetic acid. Synthesis of the 6-cyano compound IV was accomplished by treatment of the 6-bromo derivative with cuprous cyanide in N,N,N',N'-tetramethylurea. The effect of substituents on the carbonyl frequencies for 6-substituted derivatives of I was studied.

scholarly journals Actinobacillus actinomycetemcomitans induces apoptosis in human monocytic THP-1 cells

2005 ◽  
Vol 54 (3) ◽  
pp. 293-298 ◽  
Author(s):  
Satsuki Kato ◽  
Norihiko Sugimura ◽  
Keisuke Nakashima ◽  
Tatsuji Nishihara ◽  
Yusuke Kowashi
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Dna Fragmentation ◽  
P38 Mapk ◽  
Immune Cells ◽  
Periodontal Diseases ◽  
Actinobacillus Actinomycetemcomitans ◽  
Mapk Activity ◽  
Tnf Α ◽  
Human Immune

It has previously been reported that the murine macrophage cell line J774.1 and the human oral epithelial cell line KB undergo apoptosis as a result of Actinobacillus actinomycetemcomitans infection. Recent studies have demonstrated that apoptosis regulation is modulated by multiple phosphorylation of several different protein kinases, including the major subtypes of the mitogen-activated protein kinase (MAPK) family. The MAPK family promotes cell survival and/or proliferation in response to growth factor stimulation, or apoptosis in response to various stress stimuli. The primary objective of the present investigation was to clarify whether human immune cells undergo apoptosis following A. actinomycetemcomitans infection and, if so, to establish the involvement of the MAPK family. Human monocytic THP-1 cells were infected with A. actinomycetemcomitans in microtubes. Lactate dehydrogenase release into the culture supernatant and DNA fragmentation in the cells were monitored. DNA fragmentation was also identified by agarose gel electrophoresis. Cell death following A. actinomycetemcomitans infection occurred by apoptosis, shown by an increase in the proportion of fragmented DNA and the typical ladder pattern of DNA fragmentation indicative of apoptosis. Furthermore, p38 MAPK activity and tumour necrosis factor alpha (TNF-α) levels increased following A. actinomycetemcomitans infection. In contrast, cell death and TNF-α levels in infected cells decreased upon addition of a p38 inhibitor or an anti-TNF-α antibody. However, exogenous TNF-α could not induce apoptosis in uninfected THP-1 cells. Interestingly, p38 MAPK activity diminished in the presence of anti-TNF-α antibody. These findings indicated that A. actinomycetemcomitans infection induces apoptosis in THP-1 cells and that p38 MAPK activity is directly involved in apoptosis. TNF-α may play an indirect role in apoptosis via enhanced p38 MAPK activity. A. actinomycetemcomitans-induced apoptosis of human immune cells may be important in terms of initiation and progression of periodontal diseases.

Activation of human immune cells by the oncolytic parvovirus H-1 combined with chemotherapeutic or targeted agents

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
M Moehler ◽  
M Sieben ◽  
S Roth ◽  
B Leuchs ◽  
C Dinsart ◽  
...  
Keyword(s):  
Immune Cells ◽  
Targeted Agents ◽  
Human Immune
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