Glutathione-sensitive and folate-targeted nanoparticles loaded with paclitaxel to enhance oral squamous cell carcinoma therapy

2020 ◽  
Vol 8 (15) ◽  
pp. 3113-3122 ◽  
Author(s):  
Lei Fan ◽  
Jianquan Wang ◽  
Chengwan Xia ◽  
Qian Zhang ◽  
Yumei Pu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Folic Acid ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Targeted Nanoparticles

In this study, a drug delivery system based on glutathione (GSH)-sensitive and folic acid (FA)-targeted nanoparticles loaded with paclitaxel (FA-PEG-S-S-PCL@PTX, FA-NPs) was developed.

scholarly journals Evaluation of a New Hydroxyapatite Nanoparticle as a Drug Delivery System to Oral Squamous Cell Carcinoma Cells

2018 ◽  
Vol 38 (12) ◽  
pp. 6715-6720 ◽  
Author(s):  
TAKU MURATA ◽  
TOMOHIKO KUTSUNA ◽  
KAZUTO KUROHARA ◽  
KASUMI SHIMIZU ◽  
AKIRA TOMEOKU ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Carcinoma Cells

An oroxylin A-loaded aggregation-induced emission active polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma

2020 ◽  
Vol 8 (10) ◽  
pp. 2040-2047
Author(s):  
Yejin Zhu ◽  
Yongjian Guo ◽  
Mengdi Liu ◽  
Libin Wei ◽  
Xiaotang Wang
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Cancer Therapy ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Active Drug ◽  
Polymeric System ◽  
Oroxylin A

A novel AIE-active drug delivery system was developed for imaging-guided cancer therapy with improved efficacy.

scholarly journals Milk-exosome based pH/light sensitive drug system to enhance anticancer activity against oral squamous cell carcinoma

RSC Advances ◽  
2020 ◽  
Vol 10 (47) ◽  
pp. 28314-28323 ◽  
Author(s):  
Qian Zhang ◽  
Qi Xiao ◽  
Honglin Yin ◽  
Chengwan Xia ◽  
Yumei Pu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Cancer Tissues

A multimodal drug delivery system targeting the tumor microenvironment is an inspiring method for treating cancer tissues, including oral squamous cell carcinomas (OSCC).

scholarly journals Local drug delivery system for the treatment of tongue squamous cell carcinoma in rats

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Mariam Kakabadze ◽  
Teona Paresishvili ◽  
Konstantine Mardaleishvili ◽  
Zurab Vadachkoria ◽  
Nicholas Kipshidze ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Local Drug Delivery ◽  
Local Drug Delivery System

Folic acid mediated cisplatin magnetic nanodrug targeting in the treatment of oral squamous cell carcinoma

2021 ◽  
Vol 11 (8) ◽  
pp. 1299-1305
Author(s):  
Xiangyong Cheng ◽  
Lan Zhang ◽  
Xiqing Liu ◽  
Liangpeng Xu ◽  
Junjie Liu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Folic Acid ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Specific Cell ◽  
Therapeutic Effects

Cisplatin, a non-specific cell cycle antineoplastic drug, has therapeutic effects on a variety of malignant tumors. However, cisplatin has some drawbacks, such as poor targeting, which can lead to damage in normal tissue adjacent to a cancer, causing serious side effects in patients. In this study, we designed and developed a folic acid (FA)-mediated cisplatin magnetic nanodrug, FA-CDDP-MNPs, and investigated its efficacy in the treatment of oral squamous cell carcinoma (OSCC). In vitro and in vivo experiments showed that FA-CDDP-MNPs had a greater inhibitory effect on OSCC than CDDP alone. Due to the introduction of FA, the targeting of FA-CDDPMNPs was improved, and its cytotoxicity reduced. The successful design and development of FA-CDDP-MNPs provides a basis for novel drug development and design in the future.

Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma

2017 ◽  
Vol 5 (10) ◽  
pp. 2068-2078 ◽  
Author(s):  
Xiao Li ◽  
Lei Li ◽  
Yu Huang ◽  
Bing Liu ◽  
Huirong Chi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Delivery System ◽  
Squamous Cell ◽  
Chemotherapeutic Drugs ◽  
Polymeric Delivery ◽  
Anticancer Target

MutT homolog 1 (MTH1) is an essential sanitizer of the free nucleotide pool that prevents lethal DNA damage in cancer cells, which has been validated as an anticancer target in recent years.

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