Sequential Release of Autophagy Inhibitor and Chemotherapeutic Drug with Polymeric Delivery System for Oral Squamous Cell Carcinoma Therapy

2014 ◽  
Vol 11 (5) ◽  
pp. 1662-1675 ◽  
Author(s):  
Wuliji Saiyin ◽  
Dali Wang ◽  
Lili Li ◽  
Lijuan Zhu ◽  
Bing Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Delivery System ◽  
Squamous Cell ◽  
Chemotherapeutic Drug ◽  
Autophagy Inhibitor ◽  
Sequential Release ◽  
Polymeric Delivery

Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma

2017 ◽  
Vol 5 (10) ◽  
pp. 2068-2078 ◽  
Author(s):  
Xiao Li ◽  
Lei Li ◽  
Yu Huang ◽  
Bing Liu ◽  
Huirong Chi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Delivery System ◽  
Squamous Cell ◽  
Chemotherapeutic Drugs ◽  
Polymeric Delivery ◽  
Anticancer Target

MutT homolog 1 (MTH1) is an essential sanitizer of the free nucleotide pool that prevents lethal DNA damage in cancer cells, which has been validated as an anticancer target in recent years.

scholarly journals Evaluation of a New Hydroxyapatite Nanoparticle as a Drug Delivery System to Oral Squamous Cell Carcinoma Cells

2018 ◽  
Vol 38 (12) ◽  
pp. 6715-6720 ◽  
Author(s):  
TAKU MURATA ◽  
TOMOHIKO KUTSUNA ◽  
KAZUTO KUROHARA ◽  
KASUMI SHIMIZU ◽  
AKIRA TOMEOKU ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Carcinoma Cells

scholarly journals Introducing a novel chemotherapeutic drug for the treatment of oral ‎squamous cell carcinoma‎: Silver nanoparticles green-formulated by ‎ ‎Matricaria chamomilla

2021 ◽  
Author(s):  
Rui Yang ◽  
Mingguo Wang ◽  
Xiaoxia Ma ◽  
Qing Gao
Keyword(s):  
Electron Microscopy ◽  
Squamous Cell Carcinoma ◽  
Silver Nanoparticles ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Butylated Hydroxytoluene ◽  
Matricaria Chamomilla ◽  
Chemotherapeutic Drug

IntroductionIn the present research, we formulated a modern chemotherapeutic drug by silver nanoparticles ‎‎(AgNPs) containing Matricaria chamomilla aqueous extract for the treatment of oral squamous ‎cell carcinoma.Material and methodsCharacterization of AgNPs was done by UV–Visible Spectroscopy (UV-Vis), Fourier ‎Transformed Infrared Spectroscopy (FT‐IR), Transmission Electron Microscopy (TEM), and ‎Field Emission Scanning Electron Microscopy (FE‐SEM). For investigating the antioxidant ‎properties of AgNO3, M. chamomilla, and AgNPs, the DPPH test was used in the presence of ‎butylated hydroxytoluene as the positive control. To survey the cytotoxicity and anti-oral ‎squamous cell carcinoma effects of AgNO3, M. chamomilla, and AgNPs, MTT assay was used ‎on the HSC-4, Ca9-22, and HSC-3 cell lines. ‎ResultsDPPH test revealed similar antioxidant potentials for M. chamomilla‎, AgNPs, and butylated ‎hydroxytoluene. Silver nanoparticles had very low cell viability and anti-oral squamous cell ‎carcinoma properties dose-dependently against HSC-4, Ca9-22, and HSC-3 cell lines without ‎any cytotoxicity on the normal cell line. The best result of anti-oral squamous cell carcinoma ‎properties of AgNPs against the above cell lines was seen in the case of the HSC-3 cell line. ‎ConclusionsAccording to the above findings, the silver nanoparticles containing M. chamomilla aqueous ‎extract can be administrated in humans for the treatment of several types of oral squamous cell ‎carcinoma. ‎

Glutathione-sensitive and folate-targeted nanoparticles loaded with paclitaxel to enhance oral squamous cell carcinoma therapy

2020 ◽  
Vol 8 (15) ◽  
pp. 3113-3122 ◽  
Author(s):  
Lei Fan ◽  
Jianquan Wang ◽  
Chengwan Xia ◽  
Qian Zhang ◽  
Yumei Pu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Squamous Cell Carcinoma ◽  
Folic Acid ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Drug Delivery System ◽  
Delivery System ◽  
Squamous Cell ◽  
Targeted Nanoparticles

In this study, a drug delivery system based on glutathione (GSH)-sensitive and folic acid (FA)-targeted nanoparticles loaded with paclitaxel (FA-PEG-S-S-PCL@PTX, FA-NPs) was developed.

scholarly journals Combination of interferon-gamma and autophagy inhibitor as a therapeutic approach in oral squamous cell carcinoma

2020 ◽  
Author(s):  
Zhi-hang Zhou ◽  
Tong-Chao Zhao ◽  
Si-yuan Liang ◽  
Dong-wang Zhu ◽  
Zhi-yuan Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Interferon Gamma ◽  
Squamous Cell ◽  
Synergistic Effects ◽  
Cellular Growth ◽  
Autophagy Flux ◽  
Autophagy Inhibitor

Abstract Background: Former clinical trials and experimental research have indicated that interferon-gamma (IFNγ) therapy does not achieve an ideal effect in solid tumors. Autophagy has been associated with tumor chemoresistance. The aim of this study was to explore the efficacy of IFNγ and autophagy inhibitor in the combination treatment of oral squamous cell carcinoma (OSCC). Method: IFNγ-induced apoptosis was evaluated by the expression of relative proteins (cleaved-PARP and caspase-3) and flow cytometry. IFNγ-induced autophagy was assessed by the expression of Beclin1, LC3B, and P62. The synergistic effect of IFNγ and autophagy inhibitor (chloroquine) was evaluated in vitro and in vivo.Findings: IFNγ induced anti-proliferation, apoptosis, and autophagy in OSCC cells. Autophagy-related protein 5 (ATG5) was a key feature in IFNγ-induced autophagy flux. IFNγ and chloroquine had obvious synergistic effects on cellular growth inhibition and apoptosis promotion in OSCC cells and xenograft models. Interpretation: Our findings suggest that IFNγ-induced autophagy plays a cellular protective role, and blocking autophagy flux can promote IFNγ-mediated OSCC cell apoptosis. The combination of IFNγ and autophagy inhibitors represents a novel strategy for OSCC therapy.

Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Betel Quid ◽  
Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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