Stepwise dual pH and redox-responsive cross-linked polypeptide nanoparticles for enhanced cellular uptake and effective cancer therapy

2019 ◽  
Vol 7 (45) ◽  
pp. 7129-7140 ◽  
Author(s):  
Jing Qu ◽  
Rui Wang ◽  
Si Peng ◽  
Mengyao Shi ◽  
Sheng-Tao Yang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cellular Uptake ◽  
Systemic Toxicity ◽  
Cellular Internalization ◽  
Redox Responsive ◽  
Effective Cancer Therapy

The systemic toxicity, reduced cellular internalization, and uncontrollable intracellular drug release of smart nanoparticles (NPs) still need to be overcome for effective cancer therapy.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

2015 ◽  
Vol 128 (3) ◽  
pp. 1062-1067 ◽  
Author(s):  
Tianjiao Ji ◽  
Ying Zhao ◽  
Yanping Ding ◽  
Jing Wang ◽  
Ruifang Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Fibroblast Activation ◽  
Cancer Associated Fibroblast ◽  
Effective Cancer Therapy

scholarly journals Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

Small ◽  
2018 ◽  
Vol 14 (41) ◽  
pp. 1802565 ◽  
Author(s):  
Xiaoding Xu ◽  
Jun Wu ◽  
Shuaishuai Liu ◽  
Phei Er Saw ◽  
Wei Tao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Redox Responsive ◽  
Systemic Rnai ◽  
Effective Cancer Therapy

Coordination self-assembly of platinum–bisphosphonate polymer–metal complex nanoparticles for cisplatin delivery and effective cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (28) ◽  
pp. 10002-10019 ◽  
Author(s):  
Yanjuan Huang ◽  
Yuanfeng He ◽  
Ziyuan Huang ◽  
Yali Jiang ◽  
Weijing Chu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Antitumor Activity ◽  
Metal Complex ◽  
Self Assembly ◽  
Systemic Toxicity ◽  
Polymer Metal ◽  
Polymer Metal Complex ◽  
Effective Cancer Therapy

The constructed nanoparticles showed reduced systemic toxicity of cisplatin (CDDP) without compromising its in vivo antitumor activity.

Dimeric camptothecin-loaded RGD-modified targeted cationic polypeptide-based micelles with high drug loading capacity and redox-responsive drug release capability

2017 ◽  
Vol 5 (12) ◽  
pp. 2501-2510 ◽  
Author(s):  
Zhaopei Guo ◽  
Xingzhi Zhou ◽  
Mengze Xu ◽  
Huayu Tian ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Cell Apoptosis ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Redox Responsive ◽  
High Drug Loading

Dimeric CPT (DCPT) could be largely encapsulated in polypeptide micelle RGD-PEG-g-PLL-b-PLeu (DRPPP) with redox-sensitive drug release capability, showing remarkable cellular uptakeviaRGD targeting, enhanced cytotoxicity and cell apoptosis.

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