Coordination self-assembly of platinum–bisphosphonate polymer–metal complex nanoparticles for cisplatin delivery and effective cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (28) ◽  
pp. 10002-10019 ◽  
Author(s):  
Yanjuan Huang ◽  
Yuanfeng He ◽  
Ziyuan Huang ◽  
Yali Jiang ◽  
Weijing Chu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Antitumor Activity ◽  
Metal Complex ◽  
Self Assembly ◽  
Systemic Toxicity ◽  
Polymer Metal ◽  
Polymer Metal Complex ◽  
Effective Cancer Therapy

The constructed nanoparticles showed reduced systemic toxicity of cisplatin (CDDP) without compromising its in vivo antitumor activity.

scholarly journals Ferroptosis assassinates tumor (FAST)

2021 ◽  
Author(s):  
Tao Luo ◽  
Yile Wang ◽  
Jinke Wang
Keyword(s):  
Breast Cancer ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Antitumor Activity ◽  
Iron Nanoparticles ◽  
Tumor Relapse ◽  
Different Types ◽  
Current Therapies ◽  
Effective Cancer Therapy

In 2020, nearly 20 million peoples got cancer and nearly 10 million peoples died of cancer, indicating the current therapies do not meet the cancer treatment and cancer remains a great threat to human health and life. New therapies are still in urgent demand. In a recent study, we developed a new effective cancer therapy, gene-interfered ferroptosis therapy (GIFT), by combining cancer cell-specific knockdown of two iron efflux genes (FPN and LCN2) with iron nanoparticles (FeNPs). GIFT shows wide antitumor activity, high cancer specificity, certain cancer eradication potential, and biosafety. To further improve the therapy, we here develop an updated GIFT named as Ferroptosis ASsassinates Tumor (FAST) by knocking down five additional ferroptosis-resistance genes (FSP1, FTH1, GPX4, SLC7A11, NRF2). As a result, we found that FAST showed more significant antitumor activity than GIFT. Especially, FAST eradicated three different types of tumors (leukemia, colon cancer and lung metastatic melanoma) from over 50 percent of cancer mice, making the mice to survive up to 250 days without tumor relapse. FAST also significantly inhibited and prevented growth of spontaneous breast cancer and improved survival in mice. Additionally, FAST showed high pan-antitumor efficacy, high cancer specificity, and in vivo safety.

scholarly journals Chemical modification utilizing a terminal structure exposed on the specific surface of polymer-metal complex nanocrystals

RSC Advances ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 6135-6138
Author(s):  
Ryuju Suzuki ◽  
Tsunenobu Onodera ◽  
Hitoshi Kasai ◽  
Hidetoshi Oikawa
Keyword(s):  
Chemical Modification ◽  
Metal Complex ◽  
Specific Surface ◽  
Luminescence Properties ◽  
Alkylation Reaction ◽  
Polymer Metal ◽  
Polymer Metal Complex ◽  
Terminal Structure

We modified the surface of polymer metal complex nanocrystals (PMC NCs) with the alkylation reaction by utilizing coordinatively unsaturated bipyridine ligands exposed on the (010), and successfully changed the luminescence properties of PMC NCs.

scholarly journals Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhao Ma ◽  
Jin Li ◽  
Kai Lin ◽  
Mythili Ramachandran ◽  
Dalin Zhang ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
The Self ◽  
Single Drug ◽  
Drug Nanoparticles ◽  
Lysosomal Dysfunction ◽  
New Chemical Entities ◽  
Autophagy Inhibition

Abstract Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here we propose a self-delivering one-component new-chemical-entity nanomedicine (ONN) strategy to improve cancer therapy through incorporation of the self-assembly principle into drug design. A lysosomotropic detergent (MSDH) and an autophagy inhibitor (Lys05) are hybridised to develop bisaminoquinoline derivatives that can intrinsically form nanoassemblies. The selected BAQ12 and BAQ13 ONNs are highly effective in inducing lysosomal disruption, lysosomal dysfunction and autophagy blockade and exhibit 30-fold higher antiproliferative activity than hydroxychloroquine used in clinical trials. These single-drug nanoparticles demonstrate excellent pharmacokinetic and toxicological profiles and dramatic antitumour efficacy in vivo. In addition, they are able to encapsulate and deliver additional drugs to tumour sites and are thus promising agents for autophagy inhibition-based combination therapy. Given their transdisciplinary advantages, these BAQ ONNs have enormous potential to improve cancer therapy.

Polymer-Metal Complex

2016 ◽  
Author(s):  
K. Horie ◽  
M. Barón ◽  
R. B. Fox ◽  
J. He ◽  
M. Hess ◽  
...  
Keyword(s):  
Metal Complex ◽  
Polymer Metal ◽  
Polymer Metal Complex

Control of Y1Ba2Cu3Ox microstructures by polymer-metal-complex precursor synthesis

1990 ◽  
Vol 28 (8) ◽  
pp. 1999-2033 ◽  
Author(s):  
James C. W. Chien ◽  
Ben Ming Gong ◽  
Xiangi Mu ◽  
Yingsong Yang
Keyword(s):  
Metal Complex ◽  
Precursor Synthesis ◽  
Polymer Metal ◽  
Polymer Metal Complex ◽  
Complex Precursor

scholarly journals Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Menglei Huan ◽  
Shuang Tian ◽  
Han Cui ◽  
Bangle Zhang ◽  
Dan Su ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Antitumor Activity ◽  
Tumor Targeting ◽  
Circulatory System ◽  
Systemic Toxicity ◽  
Chemical Structures ◽  
Low Levels ◽  
Acid Labile

We previously reported the synthesis of three DOX conjugates that represented different targeting vehicles and showed them to have antitumor activity bothin vitroandin vivo. However, the relationships between the pharmacokinetics of these DOX conjugates and their chemical structures were not characterized. In the current study, free DOX derived from each of the conjugates was found at low levels in the rat circulatory system, with conjugated DOX being the major form. The two polyethylene glycol (PEG) conjugates slowly released DOX, andt1/2βfor total DOX from DOX-LNA, PEG-ami-DOX, and PEG-hyd-DOX was 5.79, 10.22, and 15.18 h, respectively. All three conjugates also deposited less DOX into normal organs than did an equivalent dose of free DOX, and theCmaxvalue of free DOX released by DOX- LNA, PEG-ami-DOX, and PEG-hyd-DOX was 32.5, 9.5, and 4.7 μg/g, respectively. Among the conjugates, the compound with an acid-labile bond between PEG and DOX exhibited the lowest free DOX deposition in healthy tissues, which should decrease the systemic toxicity of free DOX while allowing for tumor targeting by PEG.

Bioinspired Polymer Metal Complex Conjugates: [Co(NN)2Cl]2+ and [Cu(NN)2]2+ Moieties Graft in the Same Branched Polyethyleneimine (BPEI)—Synthesis, Biophysical and Biological Studies

2017 ◽  
Vol 27 (2) ◽  
pp. 528-541
Author(s):  
Ilayaperumal Pradeep ◽  
Balagurusamy Balajothi ◽  
Rajendran Senthilkumar ◽  
Sankaralingam Arunachalam ◽  
Thiyagarajamoorthy Dhinesh Kumar ◽  
...  
Keyword(s):  
Metal Complex ◽  
Biological Studies ◽  
Polymer Metal ◽  
Polymer Metal Complex

scholarly journals Supramolecular nanoparticles self-assembled from reduction-responsive cabazitaxel prodrugs for effective cancer therapy

2021 ◽  
Author(s):  
Jiahui Jin ◽  
Jianqin Wan ◽  
Xiaoxiao Hu ◽  
Tao Fang ◽  
Zhijian Ye ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Ethylene Glycol ◽  
Intravenous Administration ◽  
Self Assembly ◽  
Aqueous Media ◽  
The Self ◽  
Supramolecular Nanoparticles ◽  
Self Assembled ◽  
Effective Cancer Therapy

Short amphiphilic oligo(ethylene glycol)–oligolactide fragments were used to chemically modify a hydrophobic and toxic taxane drug, which induced the self-assembly of the resultant prodrug entities in aqueous media for intravenous administration.

Synthetic α-l-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy

2019 ◽  
Vol 11 (42) ◽  
pp. 38510-38518 ◽  
Author(s):  
Fei Wang ◽  
Ling Sum Liu ◽  
Cia Hin Lau ◽  
Tristan Juin Han Chang ◽  
Dick Yan Tam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Antitumor Activity ◽  
Nucleic Acids ◽  
Gene Silencing ◽  
In Vivo Antitumor Activity
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