scholarly journals Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

Small ◽  
2018 ◽  
Vol 14 (41) ◽  
pp. 1802565 ◽  
Author(s):  
Xiaoding Xu ◽  
Jun Wu ◽  
Shuaishuai Liu ◽  
Phei Er Saw ◽  
Wei Tao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Redox Responsive ◽  
Systemic Rnai ◽  
Effective Cancer Therapy

Stepwise dual pH and redox-responsive cross-linked polypeptide nanoparticles for enhanced cellular uptake and effective cancer therapy

2019 ◽  
Vol 7 (45) ◽  
pp. 7129-7140 ◽  
Author(s):  
Jing Qu ◽  
Rui Wang ◽  
Si Peng ◽  
Mengyao Shi ◽  
Sheng-Tao Yang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cellular Uptake ◽  
Systemic Toxicity ◽  
Cellular Internalization ◽  
Redox Responsive ◽  
Effective Cancer Therapy

The systemic toxicity, reduced cellular internalization, and uncontrollable intracellular drug release of smart nanoparticles (NPs) still need to be overcome for effective cancer therapy.

scholarly journals EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Wang ◽  
Jiangyong Miao ◽  
Lina Wang ◽  
Ying Liu ◽  
Hui Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Cancer Therapy ◽  
Acute Ischemic Stroke ◽  
Oral Anticoagulants ◽  
Initial Manifestation ◽  
Arterial Thromboembolism ◽  
Systemic Embolization ◽  
Effective Cancer Therapy

Abstract Background Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established. Case presentation We described a case of Trousseau’s syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. A cancer-related hypercoagulable state was suspected because the patient was admitted to the neurology department due to acute ischemic stroke with three territory infarcts on diffusion-weighted imaging (DWI) in the absence of identifiable conventional risk factors and brain vessel narrowing. The patient was subsequently diagnosed with epidermal growth factor receptor (EGFR) mutation–positive non-small-cell lung cancer (NSCLC) (stage IV) with pleural metastasis. Administration of low-molecular-weight heparin followed by long-term dabigatran under effective cancer therapy comprising gefitinib and subsequent chemotherapy did not cause stroke relapse during the 1-year follow-up. Conclusions This case suggests that cancer-related hypercoagulability should be considered an important etiology for stroke patients who develop unexplained disseminated acute cerebral infarction without conventional stroke risk factors, especially concomitant with multiple organ embolization. Novel oral anticoagulants may be an alternative therapy for the long-term management of cancer-related arterial thromboembolism under effective cancer therapy.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

2015 ◽  
Vol 128 (3) ◽  
pp. 1062-1067 ◽  
Author(s):  
Tianjiao Ji ◽  
Ying Zhao ◽  
Yanping Ding ◽  
Jing Wang ◽  
Ruifang Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Fibroblast Activation ◽  
Cancer Associated Fibroblast ◽  
Effective Cancer Therapy

Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy

2018 ◽  
Vol 7 (7) ◽  
pp. 1701510 ◽  
Author(s):  
Chenyang Xing ◽  
Shiyou Chen ◽  
Meng Qiu ◽  
Xin Liang ◽  
Quan Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Black Phosphorus ◽  
Effective Cancer Therapy

Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy

ChemPlusChem ◽  
2018 ◽  
Vol 83 (12) ◽  
pp. 1127-1134 ◽  
Author(s):  
Yixin Chen ◽  
Siyuan Xiang ◽  
Lu Wang ◽  
Mingyue Wang ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Highly Effective ◽  
Effective Cancer Therapy

Redox‐responsive Fluorescent Nanoparticles Based on Diselenide‐containing AIEgens for Cell Imaging and Selective Cancer Therapy

2018 ◽  
Vol 14 (10) ◽  
pp. 1745-1753 ◽  
Author(s):  
Wenkun Han ◽  
Song Zhang ◽  
Jingyu Qian ◽  
Jianxu Zhang ◽  
Xuanhang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Imaging ◽  
Fluorescent Nanoparticles ◽  
Redox Responsive

scholarly journals Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy

Nano Letters ◽  
2017 ◽  
Vol 17 (7) ◽  
pp. 4427-4435 ◽  
Author(s):  
Xiaoding Xu ◽  
Phei Er Saw ◽  
Wei Tao ◽  
Yujing Li ◽  
Xiaoyuan Ji ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Systemic Rnai

High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 6922-6933 ◽  
Author(s):  
Wenyan Yin ◽  
Liang Yan ◽  
Jie Yu ◽  
Gan Tian ◽  
Liangjun Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
High Throughput ◽  
Near Infrared ◽  
Single Layer ◽  
Mos2 Nanosheets ◽  
Effective Cancer Therapy

scholarly journals Corrigendum: Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy

ChemPlusChem ◽  
2021 ◽  
Author(s):  
Yixin Chen ◽  
Siyuan Xiang ◽  
Lu Wang ◽  
Mingyue Wang ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Highly Effective ◽  
Effective Cancer Therapy
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