Facile fabrication of polydopamine nanotubes for combined chemo-photothermal therapy

2019 ◽  
Vol 7 (43) ◽  
pp. 6828-6839 ◽  
Author(s):  
Yuzhe Sun ◽  
Edward W. Davis
Keyword(s):  
Photothermal Therapy ◽  
Drug Loading ◽  
Loading Capacity ◽  
Facile Fabrication

Polydopamine nanoparticles with higher drug loading capacity and enhanced photothermal behavior.

Synthesis of Janus Au nanorods/polydivinylbenzene hybrid nanoparticles for chemo-photothermal therapy

2018 ◽  
Vol 6 (16) ◽  
pp. 2481-2488 ◽  
Author(s):  
Yanming Wang ◽  
Xin Ji ◽  
Peng Pang ◽  
Yunfeng Shi ◽  
Jian Dai ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Dispersion Polymerization ◽  
Drug Loading ◽  
Hybrid Nanoparticles ◽  
Loading Capacity ◽  
Au Nanorods ◽  
Seeded Dispersion Polymerization ◽  
Photothermal Effects

Janus hybrid nanoparticles synthesized through seeded dispersion polymerization show excellent drug loading capacity and chemo-photothermal effects for anti-tumour treatment.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Exploring the drug loading mechanism of photoresponsive inorganic nanocarriers through molecular dynamics simulations

Nanoscale ◽  
2021 ◽  
Author(s):  
Stefano Motta ◽  
Paulo Siani ◽  
Andrea Levy ◽  
Cristiana Di Valentin
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Combine Therapy ◽  
Drug Loading ◽  
Drug Carriers ◽  
Inorganic Nanoparticles ◽  
Loading Capacity ◽  
Physical Stimuli ◽  
Dynamics Simulations

Inorganic nanoparticles are gaining increasing attention as drug carriers because they respond to external physical stimuli, allowing to combine therapy with diagnosis. Their drawback is a low drug loading capacity,...

scholarly journals On the Drug-Loading Capacity of Pectin Powder for Direct Compression

2012 ◽  
Vol 13 (2) ◽  
pp. 601-604
Author(s):  
Ingunn Tho ◽  
Katharina Picker-Freyer ◽  
Linda Salbu ◽  
Annette Bauer-Brandl
Keyword(s):  
Drug Loading ◽  
Direct Compression ◽  
Loading Capacity

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

scholarly journals Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Yu ◽  
Chaoqun Xu ◽  
Chuanwei Lu ◽  
Qian Liu ◽  
Jifu Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Vegetable Oils ◽  
Renewable Resources ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Dehydroabietic Acid ◽  
Great Promise ◽  
Loading Capacity ◽  
Carboxylic Groups ◽  
Ph Dependent

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

scholarly journals Synthesis and characterization of magnetic chitosan microspheres for drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 7163-7169
Author(s):  
Xin Li ◽  
Danlin Zeng ◽  
Ping Ke ◽  
Guanghui Wang ◽  
Dengke Zhang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Synthesis And Characterization ◽  
Loading Capacity ◽  
Microemulsion Polymerization ◽  
Magnetic Microsphere ◽  
Magnetic Chitosan Microspheres ◽  
Protein Drug Delivery

A novel magnetic microsphere was prepared by the simple microemulsion polymerization for protein drug delivery systems. This magnetic microsphere exhibited good magnetism and superior drug loading capacity and evident sustained-release performance.

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