scholarly journals Ultrasound-induced reactive oxygen species generation and mitochondria-specific damage by sonodynamic agent/metal ion-doped mesoporous silica

RSC Advances ◽  
2019 ◽  
Vol 9 (68) ◽  
pp. 39924-39931 ◽  
Author(s):  
Kecan Lin ◽  
Ziguo Lin ◽  
Yujie Li ◽  
Youshi Zheng ◽  
Da Zhang
Keyword(s):  
Reactive Oxygen Species ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Metal Ion ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species

Herein, we design tumor microenvironment specific active nano sono-chemodynamic agent for synergistic photodynamic–chemodynamic cancer therapy.

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

scholarly journals Synthesis of Radioluminescent CaF2:Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1447
Author(s):  
Hayden Winter ◽  
Megan J. Neufeld ◽  
Lydia Makotamo ◽  
Conroy Sun ◽  
Andrea M. Goforth
Keyword(s):  
Reactive Oxygen Species ◽  
Polyethylene Glycol ◽  
Side Effects ◽  
Mesoporous Silica ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Silica Shell ◽  
Cellular Damage ◽  
Oxygen Species ◽  
X Ray

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF2 core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu during the CaF2 core synthesis to prepare nanoparticles (NPs) with X-ray luminescent properties for potential application in fluorescence imaging. The mesoporous silica shell was added to provide the opportunity for small molecule loading, and the polyethylene glycol coating was added to impart aqueous solubility and biocompatibility. The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. Further, in vitro experiments indicate biocompatibility and enhanced cellular damage during X-ray radiotherapy.

Peroxidase-like Fe3O4 nanocomposite for activatable reactive oxygen species generation and cancer theranostics

2018 ◽  
Vol 2 (6) ◽  
pp. 1184-1194 ◽  
Author(s):  
Kai Zhang ◽  
Zhou Yang ◽  
Xiangdan Meng ◽  
Yu Cao ◽  
Yuedong Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cancer Theranostics

Photodynamic therapy (PDT) that utilizes apoptosis induced by reactive oxygen species (ROS) has received extensive attention for use in practical cancer therapy.

Enhanced highly toxic reactive oxygen species levels from iron oxide core–shell mesoporous silica nanocarrier-mediated Fenton reactions for cancer therapy

2018 ◽  
Vol 6 (37) ◽  
pp. 5876-5887 ◽  
Author(s):  
Kai Sun ◽  
Zhiguo Gao ◽  
Yu Zhang ◽  
Hongshuai Wu ◽  
Chaoqun You ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Reactive Oxygen ◽  
Core Shell ◽  
Oxygen Species ◽  
Iron Oxide Core

Highly toxic reactive oxygen species levels were enhanced via iron oxide core–shell mesoporous silica nanocarrier-mediated Fenton reactions for cancer therapy.

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