Biological Applications of Hyaluronic Acid Functionalized Nanomaterials

2011 ◽  
pp. 181-213 ◽  
Author(s):  
Mohammad El-Dakdouki ◽  
Xuefei Huang
Keyword(s):  
Hyaluronic Acid ◽  
Biological Applications ◽  
Functionalized Nanomaterials

scholarly journals Aptamer-functionalized nanomaterials for biological applications

2020 ◽  
Vol 4 (6) ◽  
pp. 1569-1585 ◽  
Author(s):  
Qiaoli Ren ◽  
Lu Ga ◽  
Zhili Lu ◽  
Jun Ai ◽  
Tie Wang
Keyword(s):  
Biological Applications ◽  
Biological Application ◽  
Functionalized Nanomaterials

This review comprehensively summarizes potential biological application using aptamer-functionalized nanomaterials platform, focusing on explaining syntheses, properties, prospects and challenges.

NUCLEIC ACID-FUNCTIONALIZED NANOMATERIALS

Nano LIFE ◽  
2013 ◽  
Vol 03 (01) ◽  
pp. 1340004 ◽  
Author(s):  
ISMAIL OCSOY ◽  
MUSERREF ARSLAN OCSOY ◽  
EMIR YASUN ◽  
WEIHONG TAN
Keyword(s):  
Nucleic Acid ◽  
Ethylene Glycol ◽  
Surface Functionalization ◽  
Wide Spectrum ◽  
Disease Diagnosis ◽  
Biocompatible Polymers ◽  
Biological Applications ◽  
Poly Ethylene Glycol ◽  
Functionalized Nanomaterials ◽  
Poly Ethylene

Nucleic acid (NA)-functionalized nanomaterials (NMs) have received considerable attention in recent years. The use of nucleic acid (DNA/RNA) for surface functionalization of NMs offers the ability to directly address desired targets and coat NMs with biocompatible polymers, such as poly [(ethylene)] glycol (PEG) and polyacrylamide (PA), enhancing the utility of these complexes in biomedicine. In particular, the target-specific recognition capacity of surface-functionalized NMs has opened up new avenues for disease diagnosis and therapy. This review focuses on the biological applications of a special type of nucleic acid, termed aptamer, conjugated with a variety of NMs for a wide spectrum of applications in nanobiomedicine.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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