scholarly journals Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15647-15658 ◽  
Author(s):  
Al de Leon ◽  
Reshani Perera ◽  
Christopher Hernandez ◽  
Michaela Cooley ◽  
Olive Jung ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Shell Structure ◽  
Ultrasound Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Stress And Deformation

We report an ultrasound contrast agent for which we engineered the shell structure to impart much better stability under intense stress and deformation.

High-Accuracy Ultrasound Contrast Agent Detection Method for Diagnostic Ultrasound Imaging Systems

2015 ◽  
Vol 41 (12) ◽  
pp. 3120-3130 ◽  
Author(s):  
Koichi Ito ◽  
Kazumasa Noro ◽  
Yukari Yanagisawa ◽  
Maya Sakamoto ◽  
Shiro Mori ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Detection Method ◽  
Ultrasound Contrast Agent ◽  
Diagnostic Ultrasound ◽  
High Accuracy ◽  
Imaging Systems ◽  
Ultrasound Contrast

scholarly journals Window-Modulated Compounding Nakagami Parameter Ratio Approach for Assessing Muscle Perfusion with Contrast-Enhanced Ultrasound Imaging

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3584
Author(s):  
Huang-Chen Lin ◽  
Shyh-Hau Wang
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agents ◽  
Muscle Disease ◽  
Contrast Enhanced Ultrasound ◽  
Time Intensity Curve ◽  
Muscle Perfusion ◽  
Ultrasound Contrast ◽  
Parameter Ratio ◽  
Contrast Enhanced

The assessment of microvascular perfusion is essential for the diagnosis of a specific muscle disease. In comparison with the current available medical modalities, the contrast-enhanced ultrasound imaging is the simplest and fastest means for probing the tissue perfusion. Specifically, the perfusion parameters estimated from the ultrasound time-intensity curve (TIC) and statistics-based time–Nakagami parameter curve (TNC) approaches were found able to quantify the perfusion. However, due to insufficient tolerance on tissue clutters and subresolvable effects, these approaches remain short of reproducibility and robustness. Consequently, the window-modulated compounding (WMC) Nakagami parameter ratio imaging was proposed to alleviate these effects, by taking the ratio of WMC Nakagami parameters corresponding to the incidence of two different acoustic pressures from an employed transducer. The time–Nakagami parameter ratio curve (TNRC) approach was also developed to estimate perfusion parameters. Measurements for the assessment of muscle perfusion were performed from the flow phantom and animal subjects administrated with a bolus of ultrasound contrast agents. The TNRC approach demonstrated better sensitivity and tolerance of tissue clutters than those of TIC and TNC. The fusion image with the WMC Nakagami parameter ratio and B-mode images indicated that both the tissue structures and perfusion properties of ultrasound contrast agents may be better discerned.

scholarly journals Intraoperative Contrast-Enhanced Ultrasound for Brain Tumor Surgery

Neurosurgery ◽  
2014 ◽  
Vol 74 (5) ◽  
pp. 542-552 ◽  
Author(s):  
Francesco Prada ◽  
Alessandro Perin ◽  
Alberto Martegani ◽  
Luca Aiani ◽  
Luigi Solbiati ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Real Time ◽  
Large Scale ◽  
Brain Lesion ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast Agents ◽  
Brain Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced

Abstract BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a dynamic and continuous modality that offers a real-time, direct view of vascularization patterns and tissue resistance for many organs. Thanks to newer ultrasound contrast agents, CEUS has become a well-established, live-imaging technique in many contexts, but it has never been used extensively for brain imaging. The use of intraoperative CEUS (iCEUS) imaging in neurosurgery is limited. OBJECTIVE: To provide the first dynamic and continuous iCEUS evaluation of a variety of brain lesions. METHODS: We evaluated 71 patients undergoing iCEUS imaging in an off-label setting while being operated on for different brain lesions; iCEUS imaging was obtained before resecting each lesion, after intravenous injection of ultrasound contrast agent. A semiquantitative, offline interobserver analysis was performed to visualize each brain lesion and to characterize its perfusion features, correlated with histopathology. RESULTS: In all cases, the brain lesion was visualized intraoperatively with iCEUS. The afferent and efferent blood vessels were identified, allowing evaluation of the time and features of the arterial and venous phases and facilitating the surgical strategy. iCEUS also proved to be useful in highlighting the lesion compared with standard B-mode imaging and showing its perfusion patterns. No adverse effects were observed. CONCLUSION: Our study is the first large-scale implementation of iCEUS in neurosurgery as a dynamic and continuous real-time imaging tool for brain surgery and provides the first iCEUS characterization of different brain neoplasms. The ability of CEUS to highlight and characterize brain tumor will possibly provide the neurosurgeon with important information anytime during a surgical procedure.

Postoperative Color Flow Duplex Scanning in Aortic Endografting

1997 ◽  
Vol 4 (3) ◽  
pp. 262-271 ◽  
Author(s):  
Peter Heilberger ◽  
Christian Schunn ◽  
Wolfgang Ritter ◽  
Sepp Weber ◽  
Dieter Raithel
Keyword(s):  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ct Scanning ◽  
Duplex Sonography ◽  
Duplex Scanning ◽  
Ultrasound Contrast ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct

Purpose: To report the feasibility and sensitivity of duplex sonography compared to computed tomography (CT) for aortic endograft follow-up surveillance. Methods: In a 26-month period, 113 aortic aneurysm patients received 79 tube and 34 bifurcated stent-grafts. Follow-up used contrast-enhanced CT scanning and duplex sonography with an intravenous ultrasound contrast agent (Levovist). Results: Eleven patients (9.7%) were converted to open repair; 1 died from hemorrhagic shock secondary to retroperitoneal hematoma. The mean follow-up time was 7.2 months (range 1 to 24), during which 5 patients died of unrelated causes. Sixteen primary (within 30 days) and 5 secondary endoleaks were detected by duplex after tube graft implantation. Among 5 endoleaks due to retrograde side-branch perfusion, 3 were detected only with contrast-enhanced duplex scanning. Iliac artery occlusion was also documented using duplex; however, 2 stent fractures could not be seen with ultrasound. Ten primary endoleaks were detected in bifurcated stent-graft patients. One endoleak originating from the distal iliac limb anchoring site was missed by duplex owing to bowel gas. Graft limb thrombosis was clearly identified by lack of a flow signal on duplex. Conclusions: Duplex sonography could be a valuable, reliable, and economical surveillance tool for endovascular aortic reconstructions. The adjunctive use of an intravenous ultrasound contrast agent increased the sensitivity for detecting endoleak to a level comparable to contrast-enhanced CT scanning. However, stent fractures may not be seen on ultrasound, and bowel gas can interfere with obtaining an adequate image.

Preparation of inclusion complex of perfluorocarbon compound with β-cyclodextrin for ultrasound contrast agent

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6305-6310 ◽  
Author(s):  
Yanjie Yao ◽  
Xunwei Liu ◽  
Tian Liu ◽  
Juan Zhou ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agent ◽  
Echo Signal ◽  
Ultrasound Contrast ◽  
Ultrasonic Echo

A novel FC-77/β-CD inclusion complex was prepared and used as a ultrasound imaging contract to enhance the ultrasonic echo signal.

scholarly journals Voiding Urosonography with Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric Reflux: First Local Pilot Study

2017 ◽  
Vol 5 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Dafina Kuzmanovska ◽  
Aleksandar Risteski ◽  
Margarita Kambovska ◽  
Tase Trpcevski ◽  
Emilija Sahpazova ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pilot Study ◽  
Contrast Agent ◽  
Second Generation ◽  
Vesicoureteric Reflux ◽  
Ultrasound Contrast Agent ◽  
Pathological Finding ◽  
Voiding Urosonography ◽  
Ultrasound Contrast ◽  
Contrast Enhanced

BACKGROUND: Vesicoureteric reflux (VUR) is an important association of paediatric urinary tract infection (UTI) found in 30-50% of all children presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS) has become an important radiation-free method for VUR detection in children. Its sensitivity in detecting VUR has greatly improved due to the development of the contrast-specific ultrasound techniques and the introduction of the second-generation ultrasound contrast agent, superseding the diagnostic accuracy of standard radiological procedures.AIM: This article aimed to summarise the current literature and discuss the first local pilot study performed in our institution on detection of vesicoureteric reflux by contrast-enhanced voiding ultrasonography with second- generation agent (SonoVue, Bracco, Italy).MATERIAL AND METHODS: Retrospective review of the first 31 ceVUS (24 girls, 7 boys) was presented.  Age range was 2 months to 18 years (mean = 6.4 ± 4.9).RESULTS:  All examinations were well tolerated without any adverse incident. VUR was shown in 20 (64.5%) children in 32/62 (51.6) nephroureteral units (NUUs). In 18 NUUs, VUR was grade II/V, in 11 Grade III/V and in 3 grade IV/V, respectively. Urethra was shown in 19/31 children and in all boys, without pathological finding. In two girls spinning top urethra has been detected. Subsequent urodynamic studies revealed functional bladder problem in both. CONCLUSIONS: Contrast-enhanced voiding urosonography using intravesical second generation ultrasound contrast agent could be recommend  as a valid alternative diagnostic modality for detecting vesicoureteral reflux and evaluation of the distal urinary tract in children, based on its radiation-free, highly efficacious, reliable, and safe characteristics.

Ultrasound Imaging Based on Magnetic Lipid Microbubble Contrast Agent with Fe3O4 Nanoparticles

2020 ◽  
Vol 20 (10) ◽  
pp. 6087-6093
Author(s):  
Liping Yan ◽  
Wei Miao ◽  
Dandan Li
Keyword(s):  
Magnetic Field ◽  
Contrast Agent ◽  
Negative Charge ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Images ◽  
Silicone Tube ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Before And After ◽  
The Magnetic Field

To construct magnetic microbubbles with dual response characteristics of ultrasound and magnetic field. The surfactant-based microbubble ultrasound contrast agent (ST68) was prepared using acoustic cavitation. Magnetic Fe3O4 nanoparticles having a negative charge on the surface were prepared by the polyol method. The microbubbles were used as the template, and the magnetic microbubbles were prepared by alternating deposition of polyethyleneimine and magnetic Fe3O4 nanoparticles on the surface of microbubbles using electrostatic attraction for a layer-by-layer selfassembly. An in vitro ultrasound contrast device was set up to compare the ultrasound images of the silicone tube in the device before and after the injection of human magnetic microbubbles (3×10/M), and to observe the movement of the magnetic microbubbles after the magnetic field was applied to the silicone tube. To evaluate the contrast effect of magnetic microbubbles in vivo, we compared the renal ultrasound images of New Zealand white rabbits before and after injection of human magnetic microbubbles. The surface of Fe3O4 nanoparticles displayed a stable negative charge (−24.6±67 mV). More than 98% of the assembled magnetic microbubbles were smaller than 8 μm, which met the basic size requirement for an ultrasound contrast agent. There was no echo signal in the silicone tube before the injection of magnetic microbubbles. Following injection, a solid echo was detected in the silicone tube. After the application of the magnetic field, the magnetic microbubbles migrated in the direction of magnetic field. Contrast-enhanced ultrasound did not image the kidney before the injection of magnetic microbubbles, while the kidney shadow was clear following injection. Magnetic targeted microbubbles and contrast-enhanced ultrasound provide good imaging, which lays the foundation for further studies of magnetic targeted microbubble contrast agents in diagnosis and treatment.

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