Preparation of inclusion complex of perfluorocarbon compound with β-cyclodextrin for ultrasound contrast agent

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6305-6310 ◽  
Author(s):  
Yanjie Yao ◽  
Xunwei Liu ◽  
Tian Liu ◽  
Juan Zhou ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agent ◽  
Echo Signal ◽  
Ultrasound Contrast ◽  
Ultrasonic Echo

A novel FC-77/β-CD inclusion complex was prepared and used as a ultrasound imaging contract to enhance the ultrasonic echo signal.

High-Accuracy Ultrasound Contrast Agent Detection Method for Diagnostic Ultrasound Imaging Systems

2015 ◽  
Vol 41 (12) ◽  
pp. 3120-3130 ◽  
Author(s):  
Koichi Ito ◽  
Kazumasa Noro ◽  
Yukari Yanagisawa ◽  
Maya Sakamoto ◽  
Shiro Mori ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Detection Method ◽  
Ultrasound Contrast Agent ◽  
Diagnostic Ultrasound ◽  
High Accuracy ◽  
Imaging Systems ◽  
Ultrasound Contrast

scholarly journals Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15647-15658 ◽  
Author(s):  
Al de Leon ◽  
Reshani Perera ◽  
Christopher Hernandez ◽  
Michaela Cooley ◽  
Olive Jung ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Shell Structure ◽  
Ultrasound Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Stress And Deformation

We report an ultrasound contrast agent for which we engineered the shell structure to impart much better stability under intense stress and deformation.

scholarly journals Preparation and Ultrasonic Imaging Investigation of Perfluoropentane-Filled Polylactic Acid Nanobubbles As a Novel Targeted Ultrasound Contrast Agent

2020 ◽  
Vol 7 ◽  
Author(s):  
Ruolei Xiao ◽  
Zhiwei Zhao ◽  
Jiajuan Chen ◽  
Liu He ◽  
Huili Wang ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Contrast Agent ◽  
Polylactic Acid ◽  
Ultrasound Imaging ◽  
Imaging System ◽  
Ultrasonic Imaging ◽  
Ultrasound Contrast Agent ◽  
Hydrodynamic Diameter ◽  
Ultrasound Contrast

In the study reported here, polylactic acid (PLLA) polymer was synthesized using stannous octoate (Sn(Oct)2) and N-(t-butoxycarbonyl) ethanolamine (EABoc) as the catalyst and the initiator, respectively. The selected PLLA polymer with proper molecular weight was used to prepare nanobubbles encapsulating with liquid perfluoropentane. Then, lactoferrin (Lf), which has a good affinity with tumor cells, was conjugated to PLLA nanobubbles. The resulting Lf–PLLA nanobubbles were examined from the perspective of appearance, size, zeta potential, and stability in vitro. The average hydrodynamic diameter of the Lf–PLLA nanobubbles was 315.3 ± 4.2 nm, the polydispersity index (PDI) was 0.153 ± 0.020, and the zeta potential was around −11.3 ± 0.2 mV. Under the transmission electron microscope (TEM), Lf–PLLA nanobubbles were highly dispersed and had a spherical shape with a distinct capsule structure. The Lf–PLLA nanobubbles also showed little cytotoxicity and low hemolysis rate and exhibited good stability in vitro. The enhanced ultrasound imaging ability of Lf–PLLA nanobubbles was detected by an ultrasound imaging system. The results of ultrasound studies in vitro showed that the liquid perfluoropentane underwent phase transition under ultrasonic treatment, which proved the Lf–PLLA nanobubbles could enhance the ability of ultrasonic imaging. The studies of ultrasonic imaging in nude mice bearing subcutaneous tumors showed that the ability of enhanced ultrasonic images was apparent after injection of Lf–PLLA nanobubbles. Acoustic behavior in vitro and in vivo showed that the Lf–PLLA nanobubbles were characterized by strong, stabilized, and the ability of tumor-enhanced ultrasound imaging. Thus, the Lf–PLLA nanobubbles are an effective ultrasound contrast agent for contrast-enhanced imaging.

Duplex Ultrasound Imaging with an Ultrasound Contrast Agent: The Economic Alternative to CT Angiography for Aortlc Sten tGraft Surveillance

2003 ◽  
Vol 37 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Phillip J. Bendick ◽  
Gerald B. Zelenock ◽  
Paul G. Bove ◽  
Graham W. Long ◽  
Charles J. Shanley ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ct Angiography ◽  
Ultrasound Imaging ◽  
Ultrasound Contrast Agent ◽  
Duplex Ultrasound ◽  
Ultrasound Contrast

Analysis of haemodynamic changes related to hepatic cirrhosis by an ultrasound contrast agent

2001 ◽  
Vol 120 (5) ◽  
pp. A2-A2
Author(s):  
G FELICIANGELI ◽  
G ARGALIA ◽  
L BOLOGNINI ◽  
T ABBATTISTA ◽  
M URBANI ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Hepatic Cirrhosis ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast ◽  
Haemodynamic Changes

scholarly journals Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Wang ◽  
Al Christopher De Leon ◽  
Reshani Perera ◽  
Eric Abenojar ◽  
Ramamurthy Gopalakrishnan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ultrasound Imaging ◽  
Prostate Gland ◽  
Ultrasound Contrast Agent ◽  
Tumor Model ◽  
Focal Therapy ◽  
Ultrasound Contrast Agents ◽  
Time Intensity Curve ◽  
Ultrasound Contrast

AbstractUltrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effectively localize malignancies for targeted biopsy or aid in patient selection and treatment planning for organ-sparing focal therapy. This study focused on evaluating the application of a novel nanobubble ultrasound contrast agent targeted to the prostate specific membrane antigen (PSMA-targeted NBs) in ultrasound imaging of prostate cancer (PCa) in vivo using a clinically relevant orthotopic tumor model in nude mice. Our results demonstrated that PSMA-targeted NBs had increased extravasation and retention in PSMA-expressing orthotopic mouse tumors. These processes are reflected in significantly different time intensity curve (TIC) and several kinetic parameters for targeted versus non-targeted NBs or LUMASON MBs. These, may in turn, lead to improved image-based detection and diagnosis of PCa in the future.

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