Ultrasound Imaging Based on Magnetic Lipid Microbubble Contrast Agent with Fe3O4 Nanoparticles

2020 ◽  
Vol 20 (10) ◽  
pp. 6087-6093
Author(s):  
Liping Yan ◽  
Wei Miao ◽  
Dandan Li
Keyword(s):  
Magnetic Field ◽  
Contrast Agent ◽  
Negative Charge ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Images ◽  
Silicone Tube ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Before And After ◽  
The Magnetic Field

To construct magnetic microbubbles with dual response characteristics of ultrasound and magnetic field. The surfactant-based microbubble ultrasound contrast agent (ST68) was prepared using acoustic cavitation. Magnetic Fe3O4 nanoparticles having a negative charge on the surface were prepared by the polyol method. The microbubbles were used as the template, and the magnetic microbubbles were prepared by alternating deposition of polyethyleneimine and magnetic Fe3O4 nanoparticles on the surface of microbubbles using electrostatic attraction for a layer-by-layer selfassembly. An in vitro ultrasound contrast device was set up to compare the ultrasound images of the silicone tube in the device before and after the injection of human magnetic microbubbles (3×10/M), and to observe the movement of the magnetic microbubbles after the magnetic field was applied to the silicone tube. To evaluate the contrast effect of magnetic microbubbles in vivo, we compared the renal ultrasound images of New Zealand white rabbits before and after injection of human magnetic microbubbles. The surface of Fe3O4 nanoparticles displayed a stable negative charge (−24.6±67 mV). More than 98% of the assembled magnetic microbubbles were smaller than 8 μm, which met the basic size requirement for an ultrasound contrast agent. There was no echo signal in the silicone tube before the injection of magnetic microbubbles. Following injection, a solid echo was detected in the silicone tube. After the application of the magnetic field, the magnetic microbubbles migrated in the direction of magnetic field. Contrast-enhanced ultrasound did not image the kidney before the injection of magnetic microbubbles, while the kidney shadow was clear following injection. Magnetic targeted microbubbles and contrast-enhanced ultrasound provide good imaging, which lays the foundation for further studies of magnetic targeted microbubble contrast agents in diagnosis and treatment.

scholarly journals Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15647-15658 ◽  
Author(s):  
Al de Leon ◽  
Reshani Perera ◽  
Christopher Hernandez ◽  
Michaela Cooley ◽  
Olive Jung ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Shell Structure ◽  
Ultrasound Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Stress And Deformation

We report an ultrasound contrast agent for which we engineered the shell structure to impart much better stability under intense stress and deformation.

Postoperative Color Flow Duplex Scanning in Aortic Endografting

1997 ◽  
Vol 4 (3) ◽  
pp. 262-271 ◽  
Author(s):  
Peter Heilberger ◽  
Christian Schunn ◽  
Wolfgang Ritter ◽  
Sepp Weber ◽  
Dieter Raithel
Keyword(s):  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ct Scanning ◽  
Duplex Sonography ◽  
Duplex Scanning ◽  
Ultrasound Contrast ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct

Purpose: To report the feasibility and sensitivity of duplex sonography compared to computed tomography (CT) for aortic endograft follow-up surveillance. Methods: In a 26-month period, 113 aortic aneurysm patients received 79 tube and 34 bifurcated stent-grafts. Follow-up used contrast-enhanced CT scanning and duplex sonography with an intravenous ultrasound contrast agent (Levovist). Results: Eleven patients (9.7%) were converted to open repair; 1 died from hemorrhagic shock secondary to retroperitoneal hematoma. The mean follow-up time was 7.2 months (range 1 to 24), during which 5 patients died of unrelated causes. Sixteen primary (within 30 days) and 5 secondary endoleaks were detected by duplex after tube graft implantation. Among 5 endoleaks due to retrograde side-branch perfusion, 3 were detected only with contrast-enhanced duplex scanning. Iliac artery occlusion was also documented using duplex; however, 2 stent fractures could not be seen with ultrasound. Ten primary endoleaks were detected in bifurcated stent-graft patients. One endoleak originating from the distal iliac limb anchoring site was missed by duplex owing to bowel gas. Graft limb thrombosis was clearly identified by lack of a flow signal on duplex. Conclusions: Duplex sonography could be a valuable, reliable, and economical surveillance tool for endovascular aortic reconstructions. The adjunctive use of an intravenous ultrasound contrast agent increased the sensitivity for detecting endoleak to a level comparable to contrast-enhanced CT scanning. However, stent fractures may not be seen on ultrasound, and bowel gas can interfere with obtaining an adequate image.

scholarly journals Voiding Urosonography with Second-Generation Ultrasound Contrast Agent for Diagnosis of Vesicoureteric Reflux: First Local Pilot Study

2017 ◽  
Vol 5 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Dafina Kuzmanovska ◽  
Aleksandar Risteski ◽  
Margarita Kambovska ◽  
Tase Trpcevski ◽  
Emilija Sahpazova ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pilot Study ◽  
Contrast Agent ◽  
Second Generation ◽  
Vesicoureteric Reflux ◽  
Ultrasound Contrast Agent ◽  
Pathological Finding ◽  
Voiding Urosonography ◽  
Ultrasound Contrast ◽  
Contrast Enhanced

BACKGROUND: Vesicoureteric reflux (VUR) is an important association of paediatric urinary tract infection (UTI) found in 30-50% of all children presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS) has become an important radiation-free method for VUR detection in children. Its sensitivity in detecting VUR has greatly improved due to the development of the contrast-specific ultrasound techniques and the introduction of the second-generation ultrasound contrast agent, superseding the diagnostic accuracy of standard radiological procedures.AIM: This article aimed to summarise the current literature and discuss the first local pilot study performed in our institution on detection of vesicoureteric reflux by contrast-enhanced voiding ultrasonography with second- generation agent (SonoVue, Bracco, Italy).MATERIAL AND METHODS: Retrospective review of the first 31 ceVUS (24 girls, 7 boys) was presented.  Age range was 2 months to 18 years (mean = 6.4 ± 4.9).RESULTS:  All examinations were well tolerated without any adverse incident. VUR was shown in 20 (64.5%) children in 32/62 (51.6) nephroureteral units (NUUs). In 18 NUUs, VUR was grade II/V, in 11 Grade III/V and in 3 grade IV/V, respectively. Urethra was shown in 19/31 children and in all boys, without pathological finding. In two girls spinning top urethra has been detected. Subsequent urodynamic studies revealed functional bladder problem in both. CONCLUSIONS: Contrast-enhanced voiding urosonography using intravesical second generation ultrasound contrast agent could be recommend  as a valid alternative diagnostic modality for detecting vesicoureteral reflux and evaluation of the distal urinary tract in children, based on its radiation-free, highly efficacious, reliable, and safe characteristics.

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