Biocompatibility of artificial micro/nanomotors for use in biomedicine

Shengnan Wang; Xiaojia Liu; Yong Wang; Dandan Xu; Chunyan Liang; Jinhong Guo; Xing Ma

doi:10.1039/c9nr03393a

Biocompatibility of artificial micro/nanomotors for use in biomedicine

Nanoscale ◽

10.1039/c9nr03393a ◽

2019 ◽

Vol 11 (30) ◽

pp. 14099-14112 ◽

Cited By ~ 21

Author(s):

Shengnan Wang ◽

Xiaojia Liu ◽

Yong Wang ◽

Dandan Xu ◽

Chunyan Liang ◽

...

Keyword(s):

Biomedical Applications ◽

The Future

This review focuses on the biocompatibility of micro/nano-motors (MNMs) with regard to the fabrication materials and propulsion mechanisms. The future prospective and suggestions on the development of MNMs towards practical biomedical applications are also proposed.

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Synthesis of C-11 and F-18 labelled compounds for biomedical applications: Current status and challenges for the future

Journal of Radioanalytical and Nuclear Chemistry ◽

10.1007/bf02041523 ◽

1996 ◽

Vol 203 (2) ◽

pp. 457-469 ◽

Cited By ~ 4

Author(s):

T. J. Ruth ◽

M. J. Adam

Keyword(s):

Biomedical Applications ◽

Current Status ◽

The Future

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Effective Control of Enzyme Activity Based on a Subtle Nanoreactor: A Promising Strategy for Biomedical Applications in the Future

ACS Applied Nano Materials ◽

10.1021/acsanm.7b00152 ◽

2017 ◽

Vol 1 (1) ◽

pp. 302-309 ◽

Cited By ~ 9

Author(s):

Ronghua Jin ◽

Zhongning Liu ◽

Yongkang Bai ◽

Yongsheng Zhou ◽

Xin Chen

Keyword(s):

Enzyme Activity ◽

Biomedical Applications ◽

Effective Control ◽

Promising Strategy ◽

The Future

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Transgenic perspectives in livestock science: a review

Australian Journal of Experimental Agriculture ◽

10.1071/ea03237 ◽

2004 ◽

Vol 44 (11) ◽

pp. 1113 ◽

Cited By ~ 1

Author(s):

M. B. Nottle ◽

A. C. Boquest ◽

S. J. Harrison ◽

C. G. Grupen ◽

R. A. Faast ◽

...

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Biomedical Applications ◽

Genetic Material ◽

Embryonic Stem ◽

Full Potential ◽

Transgenic Technology ◽

Artificial Chromosomes ◽

Fetal Fibroblasts ◽

The Future

The limitations of existing transgenic technology, the potential of cloning technology to overcome these, as well as technologies which may be available in the future for inserting new genetic material are discussed. Currently, transgenic livestock are produced by injecting hundreds to thousands of copies of a particular transgene into the pronucleus of a fertilised egg. This method suffers from a number of inherent limitations that prevent the full potential of this technology from being explored. Most of these limitations stem from the fact that it is impossible to control the site at which the transgene becomes inserted. Transgenic technology holds considerable promise for the livestock industries as well as having important biomedical applications. However, before any of these possibilities can be realised, technology is required whereby a single copy of a particular transgene can be inserted or ‘knocked in’ at a site that does not interfere with expression, as well as having the capacity to ‘knockout’ existing genes. This is possible in mice using a combination of homologous recombination and embryonic stem cell technologies. However, despite considerable effort worldwide, embryonic stem cells are yet to be isolated from any of the livestock species. The ability to clone these now means that somatic cells most notably fetal fibroblasts, can used for gene targeting purposes instead of embryonic stem cells. However, this method is not without its limitations and it is possible that more efficient methods will be developed in the future. In particular, the use of mammalian artificial chromosomes will extend this technology to allow combinations of transgenes as well as chromosomal segments to be incorporated, allowing us to explore the full potential of transgenic technology for agricultural as well as biomedical applications.

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Recent Developments in Ring-Opening Copolymerization of Epoxides With CO2 and Cyclic Anhydrides for Biomedical Applications

Frontiers in Chemistry ◽

10.3389/fchem.2021.647245 ◽

2021 ◽

Vol 9 ◽

Author(s):

Xue Liang ◽

Fei Tan ◽

Yunqing Zhu

Keyword(s):

Ring Opening ◽

Biomedical Applications ◽

Organometallic Complexes ◽

Controlled Polymerization ◽

Catalyst Development ◽

Metal Free ◽

Narrow Scope ◽

Recent Advances ◽

The Future ◽

Recent Developments

The biomedical applications of polyesters and polycarbonates are of interest due to their potential biocompatibility and biodegradability. Confined by the narrow scope of monomers and the lack of controlled polymerization routes, the biomedical-related applications of polyesters and polycarbonates remain challenging. To address this challenge, ring-opening copolymerization (ROCOP) has been exploited to prepare new alternating polyesters and polycarbonates, which would be hard to synthesize using other controlled polymerization methods. This review highlights recent advances in catalyst development, including the emerging dinuclear organometallic complexes and metal-free Lewis pair systems. The post-polymerization modification methods involved in tailoring the biomedical functions of resultant polyesters and polycarbonates are summarized. Pioneering attempts for the biomedical applications of ROCOP polyesters and polycarbonates are presented, and the future opportunities and challenges are also highlighted.

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