scholarly journals Biomedical Applications of Gut Stem Cells: Gaining First-Hand Insights for Developing Therapy for the Future

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Upendra K Kar
Keyword(s):  
Stem Cells ◽  
Biomedical Applications ◽  
The Future

Transgenic perspectives in livestock science: a review

2004 ◽  
Vol 44 (11) ◽  
pp. 1113 ◽  
Author(s):  
M. B. Nottle ◽  
A. C. Boquest ◽  
S. J. Harrison ◽  
C. G. Grupen ◽  
R. A. Faast ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Biomedical Applications ◽  
Genetic Material ◽  
Embryonic Stem ◽  
Full Potential ◽  
Transgenic Technology ◽  
Artificial Chromosomes ◽  
Fetal Fibroblasts ◽  
The Future

The limitations of existing transgenic technology, the potential of cloning technology to overcome these, as well as technologies which may be available in the future for inserting new genetic material are discussed. Currently, transgenic livestock are produced by injecting hundreds to thousands of copies of a particular transgene into the pronucleus of a fertilised egg. This method suffers from a number of inherent limitations that prevent the full potential of this technology from being explored. Most of these limitations stem from the fact that it is impossible to control the site at which the transgene becomes inserted. Transgenic technology holds considerable promise for the livestock industries as well as having important biomedical applications. However, before any of these possibilities can be realised, technology is required whereby a single copy of a particular transgene can be inserted or ‘knocked in’ at a site that does not interfere with expression, as well as having the capacity to ‘knockout’ existing genes. This is possible in mice using a combination of homologous recombination and embryonic stem cell technologies. However, despite considerable effort worldwide, embryonic stem cells are yet to be isolated from any of the livestock species. The ability to clone these now means that somatic cells most notably fetal fibroblasts, can used for gene targeting purposes instead of embryonic stem cells. However, this method is not without its limitations and it is possible that more efficient methods will be developed in the future. In particular, the use of mammalian artificial chromosomes will extend this technology to allow combinations of transgenes as well as chromosomal segments to be incorporated, allowing us to explore the full potential of transgenic technology for agricultural as well as biomedical applications.

An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications

2018 ◽  
Vol 15 (2) ◽  
pp. 286-313 ◽  
Author(s):  
Manash P. Borgohain ◽  
Krishna Kumar Haridhasapavalan ◽  
Chandrima Dey ◽  
Poulomi Adhikari ◽  
Rajkumar P. Thummer
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Biomedical Applications ◽  
Induced Pluripotent ◽  
Insight Into

scholarly journals Stem cells: technologies for the future

BioTechniques ◽  
2003 ◽  
Vol 35 (6) ◽  
pp. 1232
Author(s):  
Margaret A. Goodell
Keyword(s):  
Stem Cells ◽  
The Future

Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85756-85766 ◽  
Author(s):  
E. Jäger ◽  
R. K. Donato ◽  
M. Perchacz ◽  
A. Jäger ◽  
F. Surman ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Growth Promotion ◽  
Intrinsic Properties ◽  
Biofilm Inhibition

Poly(alkene succinates) are promising materials for specialized medical devices and tissue engineering, presenting intrinsic properties, such as; fungal biofilm inhibition, biocompatibility and stem cells controlled growth promotion.

Mesenchymal stem cells strategies in cancer immunotherapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Animal Models ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Human Studies ◽  
Research Focus ◽  
Cancer Treatments ◽  
The Future ◽  
New Research

Mesenchymal stem cells (MSCs) have been a new research focus for cancer treatment. Future cancer sufferers will considerably profit from their use in the future. Tumor-directed migratory and integration capacities of MSCs are exceptional, making them potential carriers for the delivery of anticancer medicines, notably cytokines. Their usage in the clinic has lasted around 10 years. The use of mesenchymal stem cells (MSCs) to create successful cancer treatments has been demonstrated in everything from animal models to human studies.

Sign in / Sign up

Export Citation Format

Share Document