A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2017 ◽  
Vol 9 (27) ◽  
pp. 9428-9439 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Nanodrug Delivery ◽  
System P ◽  
Multiple Signaling

Anti-tumor and anti-metastatic effects of ursolic acid based on one novel nanodrug delivery system.

scholarly journals Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 6212-6213 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Signaling Pathways ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Multiple Signaling

Correction for ‘A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways’ by Kai Jiang et al., Nanoscale, 2017, 9, 9428–9439.

Formation of pH-responsive drug-delivery systems by electrospinning of vesicle-templated nanocapsule solutions

RSC Advances ◽  
2016 ◽  
Vol 6 (48) ◽  
pp. 42589-42595 ◽  
Author(s):  
W. Li ◽  
X. N. Tan ◽  
T. Luo ◽  
X. Huang ◽  
Q. Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Electrospinning Process ◽  
Nanofibrous Membrane ◽  
Ph Responsive ◽  
System P

A novel nanofibrous membrane, which contains chitosan/sodium alginate nanocapsules constructed by vesicle systems, has been fabricated via an electrospinning process as a drug-delivery system.

Synthesis of fluorescent nitrogen-doped carbon dots from dried shrimps for cell imaging and boldine drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (15) ◽  
pp. 12169-12179 ◽  
Author(s):  
Stephanie L. D'souza ◽  
Balaji Deshmukh ◽  
Jigna R. Bhamore ◽  
Karuna A. Rawat ◽  
Nibedita Lenka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Carbon Dots ◽  
Human Breast ◽  
System P ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon ◽  
Mcf 7

Fluorescent N-doped carbon dots were synthesized using dried shrimps as precursors and rationally fabricated as a traceable drug delivery system for the targeted delivery of boldine to human breast cancer cells (MCF-7 cells).

scholarly journals Cancer, Natural Products and Nanodrug Delivery Systems

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Yong Sze Ong ◽  
Loh Teng-Hern Tan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Uptake ◽  
Biomedical Sciences ◽  
Nanodrug Delivery ◽  
Conventional Drug ◽  
Living Organisms

As an offshoot of nanotechnology, nanomedicine has made great impact in the field of pharmaceutical and biomedical sciences by achieving breakthroughs in therapeutics and diagnostics of diseases in living organisms. One of the promising breakthroughs is the application of natural product-based nanoformulations for the treatment of various human diseases, such as cancer. Principally, the nanoparticle-based drug delivery system (NDDS) aims to overcome the limitations of conventional drug delivery system. NDDS improves the in vivo pharmacological and therapeutic properties of the poorly soluble drugs by dissolving, encapsulating, absorbing and/or attaching the drugs with the matrices of the nanoparticles. The nanoparticles that act as drug reservoirs also aim to control the drug release, enhance the drug uptake by targeted delivery and protect the drug against enzymatic degradation. This review presents a summary of the integration of nanotechnology and phytotherapy to achieve an improved pharmacological response and better clinical outcome in patients undergoing chemotherapy.

pH-Responsive reversibly cross-linked micelles by phenol–yne click via curcumin as a drug delivery system in cancer chemotherapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3884-3893 ◽  
Author(s):  
Yuancheng Liu ◽  
Fan Chen ◽  
Kui Zhang ◽  
Quan Wang ◽  
Yuanwei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Cross Linking ◽  
Ph Responsive ◽  
System P

pH-sensitive reversibly cross-linked micelles by phenol–yne click via curcumin (Cur) using mPEG-b-PHEMA-5HA are developed by combining drug loading and cross-linking as a drug delivery system.

pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

2018 ◽  
Vol 54 (28) ◽  
pp. 3520-3523 ◽  
Author(s):  
Hui Li ◽  
Xiang Zhou ◽  
Dongbao Yao ◽  
Haojun Liang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Ph Responsive ◽  
Spherical Nucleic Acid ◽  
System P ◽  
Spherical Nucleic Acids

This study presents a class of pH-responsive spherical nucleic acids that can exactly image intracellular lysosomes and be an effective drug delivery system.

scholarly journals Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system

2020 ◽  
Vol 11 (24) ◽  
pp. 6275-6282 ◽  
Author(s):  
Junyi Chen ◽  
Yadan Zhang ◽  
Zhao Meng ◽  
Lei Guo ◽  
Xingyi Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Combination Chemotherapy ◽  
Chemotherapeutic Agents ◽  
Ph Responsive ◽  
System P

Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic agents. A supramolecular approach that may allow co-delivery of two drugs is described here.

A novel approach for the synthesis of phospholipid bilayer-coated zeolitic imidazolate frameworks: preparation and characterization as a pH-responsive drug delivery system

2019 ◽  
Vol 43 (4) ◽  
pp. 1956-1963 ◽  
Author(s):  
Nadia Nasihat Sheno ◽  
Saeed Farhadi ◽  
Aziz Maleki ◽  
Mehrdad Hamidi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Phospholipid Bilayer ◽  
Zeolitic Imidazolate Frameworks ◽  
Ph Responsive ◽  
Novel Approach ◽  
System P

The first example of enveloping of the ZIF family by PLB as an effective biodegradable/biocompatible/responsive drug delivery system.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system

2021 ◽  
Vol 45 (6) ◽  
pp. 3079-3087
Author(s):  
Yue Xu ◽  
Mingming Yang ◽  
Qiyue Ma ◽  
Xiang Di ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fluorescence Properties ◽  
Injectable Hydrogel ◽  
Sequential Release ◽  
System P

A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs.

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