scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

Coordination polymer nanocapsules prepared using metal–organic framework templates for pH-responsive drug delivery

2017 ◽  
Vol 28 (27) ◽  
pp. 275601 ◽  
Author(s):  
Lei Tang ◽  
Jiafu Shi ◽  
Xiaoli Wang ◽  
Shaohua Zhang ◽  
Hong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery

2018 ◽  
Vol 225 ◽  
pp. 142-144 ◽  
Author(s):  
Ke Jiang ◽  
Ling Zhang ◽  
Quan Hu ◽  
Yanyu Yang ◽  
Wenxin Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

Hollow Mesoporous Silica@Metal-Organic Framework and Applications for pH-Responsive Drug Delivery

ChemMedChem ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Xiaomin Jia ◽  
Zhiyuan Yang ◽  
Yujun Wang ◽  
Ya Chen ◽  
Haitao Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Organic Framework

A versatile stimulus-responsive metal–organic framework for size/morphology tunable hollow mesoporous silica and pH-triggered drug delivery

2017 ◽  
Vol 5 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Zhen Zou ◽  
Siqi Li ◽  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Three Dimensional ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Stimulus Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Pore Blocker

The ZIF-8 is applied for the preparation of size tunable three-dimensional hollow mesoporous silica materials (HMSNs) and used as a novel pore blocker for pH-responsive intracellular drug delivery system by grafting it onto the HMSN.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

2018 ◽  
Vol 6 (1) ◽  
pp. 1801526 ◽  
Author(s):  
Wen Cai ◽  
Junqing Wang ◽  
Chengchao Chu ◽  
Wei Chen ◽  
Chunsheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Stimuli Responsive ◽  
Responsive Systems ◽  
Metal Organic ◽  
Organic Framework

scholarly journals A combination of glioma in vivo imaging and in vivo drug delivery by metal–organic framework based composite nanoparticles

2019 ◽  
Vol 7 (48) ◽  
pp. 7683-7689 ◽  
Author(s):  
Yuan-Bo Pan ◽  
Siqi Wang ◽  
Xiuchao He ◽  
Weiwei Tang ◽  
Jianhua Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Loading Rate ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Composite Nanoparticles ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Metal Organic ◽  
Organic Framework

Metal–organic framework based composite nanoparticles (Mn-ZIF-8/5-Fu) was used for glioma treatment with high drug loading rate and pH responsive drug delivery capacity. Mn-ZIF-8/5-Fu demonstrated good magnetic resonance imaging capacity.

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