A versatile stimulus-responsive metal–organic framework for size/morphology tunable hollow mesoporous silica and pH-triggered drug delivery

2017 ◽  
Vol 5 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Zhen Zou ◽  
Siqi Li ◽  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Three Dimensional ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Stimulus Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Pore Blocker

The ZIF-8 is applied for the preparation of size tunable three-dimensional hollow mesoporous silica materials (HMSNs) and used as a novel pore blocker for pH-responsive intracellular drug delivery system by grafting it onto the HMSN.

Hollow Mesoporous Silica@Metal-Organic Framework and Applications for pH-Responsive Drug Delivery

ChemMedChem ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Xiaomin Jia ◽  
Zhiyuan Yang ◽  
Yujun Wang ◽  
Ya Chen ◽  
Haitao Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Organic Framework

scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

An Adeninate-Based Metal–Organic Framework for Antitumour Drug Delivery and Anti-Osteogenic Sarcoma Activity Evolution

2018 ◽  
Vol 71 (12) ◽  
pp. 978
Author(s):  
Bing Yan ◽  
Huanqiu Li ◽  
Wenyan Jiang ◽  
Long Mu
Keyword(s):  
Drug Delivery ◽  
Ph Value ◽  
Antitumour Activity ◽  
Metal Organic Framework ◽  
Osteogenic Sarcoma ◽  
Three Dimensional ◽  
Building Blocks ◽  
Therapy Effect ◽  
Metal Organic ◽  
Organic Framework

Targeted anticancer drug delivery systems (DDSs) have been considered as one of the most important approaches for reducing the side effects and enhancing the therapy effect in cancer treatment. This work presents a targeted anticancer DDS on the basis of a newly synthesised adeninate-based metal–organic framework (MOF) [Zn2(ad)2(AMDB)(H2O)](DMF)3 (1) with biomolecular adenine (HAd), zinc(ii) ions, and 4,4′-(aminomethylene)dibenzoic acid (H2AMDB) as the molecular building blocks. The structural analysis via X-ray diffraction technology shows MOF 1 is a channel-type three-dimensional network composed of rod-like Zn–Ad chains. Due to its large inner free spaces and uncoordinated N donor sites functionalised pore surroundings, the antitumour molecule 5-fluorouracil (5-Fu) could be loaded into the pores of 1a (activated 1) though an adsorption process, which shows a moderate high storage capacity of 32 wt-%. At the same time, the pH-dependent delivery of 5-Fu could be achieved in phosphate-buffered saline (PBS) solution. With a lower pH value, the drug release will be enhanced. Furthermore, the invitro antitumour activity of the drug/1a composite has been probed via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on two human osteogenic sarcoma cells (MG63 and U2OS).

Coordination polymer nanocapsules prepared using metal–organic framework templates for pH-responsive drug delivery

2017 ◽  
Vol 28 (27) ◽  
pp. 275601 ◽  
Author(s):  
Lei Tang ◽  
Jiafu Shi ◽  
Xiaoli Wang ◽  
Shaohua Zhang ◽  
Hong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

A combination of tri-modal cancer imaging and in vivo drug delivery by metal–organic framework based composite nanoparticles

2015 ◽  
Vol 3 (9) ◽  
pp. 1270-1278 ◽  
Author(s):  
Ruixin Bian ◽  
Tingting Wang ◽  
Lingyu Zhang ◽  
Lu Li ◽  
Chungang Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Storage Capacity ◽  
Cancer Imaging ◽  
Metal Organic Framework ◽  
Composite Nanoparticles ◽  
Ph Responsive ◽  
Drug Storage ◽  
Metal Organic

A facile method was developed for the synthesis of multifunctional Fe3O4@PAA/AuNCs/ZIF-8 NPs. Furthermore, the obtained NPs with ultrahigh drug storage capacity and dual pH-responsive drug release properties were applicable in simultaneous tri-modal.

A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery

2018 ◽  
Vol 225 ◽  
pp. 142-144 ◽  
Author(s):  
Ke Jiang ◽  
Ling Zhang ◽  
Quan Hu ◽  
Yanyu Yang ◽  
Wenxin Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework
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