scholarly journals A combination of glioma in vivo imaging and in vivo drug delivery by metal–organic framework based composite nanoparticles

2019 ◽  
Vol 7 (48) ◽  
pp. 7683-7689 ◽  
Author(s):  
Yuan-Bo Pan ◽  
Siqi Wang ◽  
Xiuchao He ◽  
Weiwei Tang ◽  
Jianhua Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Loading Rate ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Composite Nanoparticles ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Metal Organic ◽  
Organic Framework

Metal–organic framework based composite nanoparticles (Mn-ZIF-8/5-Fu) was used for glioma treatment with high drug loading rate and pH responsive drug delivery capacity. Mn-ZIF-8/5-Fu demonstrated good magnetic resonance imaging capacity.

A combination of tri-modal cancer imaging and in vivo drug delivery by metal–organic framework based composite nanoparticles

2015 ◽  
Vol 3 (9) ◽  
pp. 1270-1278 ◽  
Author(s):  
Ruixin Bian ◽  
Tingting Wang ◽  
Lingyu Zhang ◽  
Lu Li ◽  
Chungang Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Storage Capacity ◽  
Cancer Imaging ◽  
Metal Organic Framework ◽  
Composite Nanoparticles ◽  
Ph Responsive ◽  
Drug Storage ◽  
Metal Organic

A facile method was developed for the synthesis of multifunctional Fe3O4@PAA/AuNCs/ZIF-8 NPs. Furthermore, the obtained NPs with ultrahigh drug storage capacity and dual pH-responsive drug release properties were applicable in simultaneous tri-modal.

scholarly journals Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junfeng Huang ◽  
Zhourui Xu ◽  
Yihang jiang ◽  
Wing-cheung Law ◽  
Biqin Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Zeolitic Imidazolate Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

AbstractChemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

scholarly journals Multi-modal channel cancer chemotherapy by 2D functional gadolinium metal-organic framework

2020 ◽  
Author(s):  
Jiale Xia ◽  
Yumeng Xue ◽  
Bo Lei ◽  
Lingling Xu ◽  
Mingzi Sun ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Tumor Tissue ◽  
Tumor Imaging ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
High Surface ◽  
Superior Performance ◽  
Metal Organic ◽  
Organic Framework

Abstract Two-dimensional (2D) nanomaterials generally exhibit enhanced physiochemical and biological functions in biomedical applications due to their high surface-to-volume ratio and surface charge. Conventional cancer chemotherapy based on nanomaterials has been hindered by their low drug loading and poor penetration in tumor tissue. To overcome these difficulties, the novel materials systems are urgently needed. Hereby, the lanthanide-based porphyrin metal organic framework (MOF) nanosheets with promising cancer imaging/chemotherapy capacities are fabricated, which displays superior performance in the drug loading and tumor tissue penetration. The biodegradable PPF-Gd nanosheets deliver an ultrahigh drug loading (>1500%) and demonstrate the stable and highly sensitive stimuli-responsive degradation/release for multimodal tumor imaging and cancer chemotherapy. Meanwhile, PPF-Gd NSs also exhibits excellent fluorescence and magnetic resonance imaging capability in vitro and in vivo. Compared to the traditional DOX chemotherapy, the in vivo results confirm the evident suppression of the tumor growth by the PPF-Gd/DOX drug delivery system with negligible side effects. This work further supports the potential of lanthanide-based MOF nanomaterials as biodegradable systems to promote the cancer theranostics technology development in the future.

Coordination polymer nanocapsules prepared using metal–organic framework templates for pH-responsive drug delivery

2017 ◽  
Vol 28 (27) ◽  
pp. 275601 ◽  
Author(s):  
Lei Tang ◽  
Jiafu Shi ◽  
Xiaoli Wang ◽  
Shaohua Zhang ◽  
Hong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymer ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery

2018 ◽  
Vol 225 ◽  
pp. 142-144 ◽  
Author(s):  
Ke Jiang ◽  
Ling Zhang ◽  
Quan Hu ◽  
Yanyu Yang ◽  
Wenxin Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Organic Framework

Hollow Mesoporous Silica@Metal-Organic Framework and Applications for pH-Responsive Drug Delivery

ChemMedChem ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Xiaomin Jia ◽  
Zhiyuan Yang ◽  
Yujun Wang ◽  
Ya Chen ◽  
Haitao Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Ph Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Organic Framework

scholarly journals Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2038-2051 ◽  
Author(s):  
Weicong Liu ◽  
Ying Pan ◽  
Weiwei Xiao ◽  
Hongjia Xu ◽  
Dong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Review Article ◽  
The Body ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Stimulus Responsive ◽  
Recent Developments ◽  
Metal Organic ◽  
Organic Framework

In this review article, we discuss the diverse stimuli achieved upon outside activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints in the body.

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