scholarly journals Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice

2019 ◽  
Vol 10 (10) ◽  
pp. 6331-6341 ◽  
Author(s):  
Xiaokun Cai ◽  
Yanhui Han ◽  
Min Gu ◽  
Mingyue Song ◽  
Xian Wu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oral Administration ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation ◽  
Freeze Dried ◽  
Gut Microbiota Dysbiosis

Oral administration of freeze-dried whole cranberry powder via diet inhibited colitis in dextran sodium sulfate-treated mice, which was associated with modification of gut microbiota.

Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

2021 ◽  
Author(s):  
fan wan ◽  
Hui Han ◽  
Ruqing Zhong ◽  
Mengyu Wang ◽  
Shanlong Tang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

The purpose of the current study was to investigate the effect of dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ supplementation (3...

scholarly journals Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis

2018 ◽  
Vol 51 (1) ◽  
pp. 441-451 ◽  
Author(s):  
Gang Liu ◽  
Wenxin Yan ◽  
Sujuan  Ding ◽  
Hongmei Jiang ◽  
Yong Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Daily Weight Gain ◽  
Control Group ◽  
Unrestricted Access ◽  
Hematoxylin And Eosin ◽  
Colitis Model

Background/Aims: There are known links between inflammatory bowel disease (IBD) and changes in the microbiota of the gut and inflammation and oxidative stress. In this study, a colitis model induced by dextran sodium sulfate (DSS) in mice is used to evaluate whether the presence of bioactive peptides IRW (Ile-Arg-Trp) and IQW (Ile-Gln-Trp) peptides is advantageous. Methods: The mice were arbitrarily assigned to the following four groups: (i) control (untreated), (ii) dextran sodium sulfate (DSS) treated, (iii) IRW-DSS treated, and (iv) IQW-DSS treated. For 7 days, the control group subjects had unrestricted access to untreated drinking water, whereas the drinking water supplied to the subjects in the DSS, IRW-DSS, and IQW-DSS groups during this period consisted of 5% DSS solution. The colonic lesions were scored after hematoxylin and eosin staining. Serum antioxidant capacity was analyzed by 2,2’-azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) radical cation decolorization test and the microbiota in the colonic contents were sequenced by HiSeq2500 PE250. Results: The presence of DSS reduced daily weight gain, enhanced histopathology scores, and inhibited antioxidant enzyme expression. Superoxide dismutase, catalase, and glutathione peroxidase activities in the DSS-induced colitis model were significantly enhanced (P < 0.05) in the presence of dietary IRW and IQW. Furthermore, the Simpson index was significantly increased (P < 0.05) in the presence of dietary IRW and IQW compared to the control group. IRW and IQW increased the abundance of Coprococcus_1, Ruminococcaceae_UCG-014, and Desulfovibrio compared to the control group and DSS group. Furthermore, IQW decreased the abundance of Bacteroides in relation to the control group, but increased Parabacteroides. In addition, IRW increased the level of Anaerotruncus, Oscillibacter, and Ruminiclostridium_9 compared to the control group. Conclusion: This study concludes that the presence of IRW or IQW can mitigate DSS-induced oxidative stress by improving the activities of antioxidant enzymes, increasing intestinal microbial diversity and enhancing the abundance of gut microbiota, which may help maintain the homeostasis of host health and microenvironment in a DSS-induced mouse model, thus providing a potential further treatment for IBD patients.

scholarly journals Exopolysaccharides from Bacillus amyloliquefaciens DMBA-K4 ameliorate dextran sodium sulfate-induced colitis via gut microbiota modulation

2020 ◽  
Vol 75 ◽  
pp. 104212
Author(s):  
Jia-hua Kuang ◽  
Yan-yan Huang ◽  
Jin-shuang Hu ◽  
Jia-jia Yu ◽  
Qin-yu Zhou ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Bacillus Amyloliquefaciens ◽  
Dextran Sodium Sulfate

Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice

2020 ◽  
Vol 11 (5) ◽  
pp. 4259-4274
Author(s):  
Ruiqiu Zhao ◽  
Yang Ji ◽  
Xin Chen ◽  
Anxiang Su ◽  
Gaoxing Ma ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Flammulina Velutipes ◽  
Anti Inflammation

Using the Flammulina velutipes polysaccharide (FVP) extracted from our previous study, herein, we investigated the improvement of this β-type glycosidic polysaccharide in alleviating dextran sodium sulfate-induced ulcerative colitis (UC) in mice.

NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice

2018 ◽  
Vol 41 ◽  
pp. 240-249 ◽  
Author(s):  
Nirmal Kumar Kasinathan ◽  
Bharathraja Subramaniya ◽  
Niranjali Devaraj Sivasithamparam
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals Slight Disruption in Intestinal Environment by Dextran Sodium Sulfate Reduces Egg Yolk Size Through Disfunction of Ovarian Follicle Growth

2021 ◽  
Vol 11 ◽  
Author(s):  
Takahiro Nii ◽  
Takashi Bungo ◽  
Naoki Isobe ◽  
Yukinori Yoshimura
Keyword(s):  
Gene Expression ◽  
Oral Administration ◽  
Blood Plasma ◽  
Sodium Sulfate ◽  
Egg Production ◽  
Laying Hens ◽  
Ovarian Follicle ◽  
Egg Yolk ◽  
Dextran Sodium Sulfate ◽  
Intestinal Environment

Intestinal environments such as microbiota, mucosal barrier function, and cytokine production affect egg production in laying hens. Dextran sodium sulfate (DSS) is an agent that disrupts the intestinal environment. Previously, we reported that the oral administration of dextran sodium sulfate (DSS: 0.9 g/kg BW) for 5 days caused severe intestinal inflammation in laying hens. However, the DSS concentration in the previous study was much higher to induce a milder disruption of the intestinal environment without heavy symptoms. Thus, the goal of this study was to determine the effects of a lower dose of DSS on the intestinal environment and egg production in laying hens. White Leghorn laying hens (330-day old) were oral administered with or without 0.225 g DSS/kg BW for 28 days (DSS and control group: n = 7 and 8, respectively). Weekly we collected all laid eggs and blood plasma samples. Intestinal tissues, liver, ovarian follicles, and the anterior pituitary gland were collected 1 day after the final treatment. Lower concentrations of orally administered DSS caused (1) a decrease in the ratio of villus height/crypt depth, occludin gene expressions in large intestine and cecal microbiota diversity, (2) a decrease in egg yolk weight, (3) an increase in VLDLy in blood plasma, (4), and enhanced the egg yolk precursor accumulation in the gene expression pattern in the follicular granulosa layer, (5) an increase in FSH and IL-1β gene expression in the pituitary gland, and (6) an increase in concentration of plasma lipopolysaccharide binding protein. These results suggested that the administration of the lower concentration of DSS caused a slight disruption in the intestinal environment. This disruption included poor intestinal morphology and decreased cecal microbiome diversity. The change in the intestinal environment decreases egg yolk size without decreasing the VLDLy supply from the liver. The decrease in egg yolk size is likely to be caused by the dysfunction of egg-yolk precursor uptake in ovarian follicles. In conclusion, the oral administration of a lower dose of DSS is an useful method to cause slight disruptions of intestinal environment, and the intestinal condition decreases egg yolk size through disfunction of ovarian follicle.

scholarly journals Dietary Pterostilbene Inhibited Colonic Inflammation in Dextran-Sodium-Sulfate-Treated Mice

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Fang Li ◽  
Qi Wang ◽  
Yanhui Han ◽  
Mingyue Song ◽  
Xiaokun Cai ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

2020 ◽  
Vol 10 ◽  
Author(s):  
Hao Wu ◽  
Quan Rao ◽  
Guang-Chao Ma ◽  
Xiao-Hong Yu ◽  
Cong-En Zhang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate
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