NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in mice

2018 ◽  
Vol 41 ◽  
pp. 240-249 ◽  
Author(s):  
Nirmal Kumar Kasinathan ◽  
Bharathraja Subramaniya ◽  
Niranjali Devaraj Sivasithamparam
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals Dietary Pterostilbene Inhibited Colonic Inflammation in Dextran-Sodium-Sulfate-Treated Mice

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Fang Li ◽  
Qi Wang ◽  
Yanhui Han ◽  
Mingyue Song ◽  
Xiaokun Cai ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals MiR-223 improves intestinal inflammation through inhibiting the IL-6/STAT3 signaling pathway in dextran sodium sulfate-induced experimental colitis

2020 ◽  
Author(s):  
Juanjuan Zhang ◽  
Chenyang Wang ◽  
Zhen Guo ◽  
Binlin Da ◽  
Weiming Zhu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Sodium Sulfate ◽  
Quantitative Polymerase Chain Reaction ◽  
Negative Control ◽  
Dextran Sodium Sulfate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Colonic Inflammation ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Tnf Α

Abstract Background: The pathogenesis of inflammatory bowel disease (IBD) has not yet been clarified and is closely related to several proinflammatory factors. MicroRNA-233 (miR-223) might be involved in the development of IBD; however, the mechanism underlying its pathogenesis is unclear. In this study, we attempted to determine the role of miR-223 in dextran sodium sulfate (DSS)-induced colitis and explore the involvement of the IL-6/STAT3 pathway in the development of intestinal mucosal inflammation.Methods: Male C57BL/6 mice were divided into six groups: control (WT) group, DSS group, DSS+miR-223 agomir (DSS+A) group, DSS+miR-223 agomir negative control (DSS+A+NC) group, DSS+miR-223 antagomir (DSS+AN) group and DSS+miR-223 antagomir negative control (DSS+AN+NC) group. Body weight, stool consistency, fecal blood and the disease activity index (DAI) score were recorded daily. The length of each colon was measured, and colonic inflammation was evaluated with hematoxylin and eosin (H&E) staining and histopathological scoring. The expression of myeloperoxidase (MPO), TNF-α, IL-6, IL-10 and IL-17 in the colonic tissues was measured by Enzyme-linked Immunosorbent Assay (ELISA) and real-time quantitative polymerase chain reaction (RT-qPCR). The mRNA expression of gp130, Bcl-2 and Bcl-xl in the colon was measured using RT-qPCR. The colonic levels of STAT3 and p-STAT3 were determined by Western blotting.Results: MiR-223 expression in the terminal ileum and colon was increased in the DSS group compared with the WT group. Colitis symptoms were significantly alleviated in the DSS+A group and exacerbated in the DSS+AN group after administration of the miR-223 agomir and antagomir, respectively. MPO, TNF-α, IL-6 and IL-17 were decreased and IL-10 was increased in the DSS+A group, but these changes were reversed in the DSS+AN group. Gp130 mRNA, p-STAT3, Bcl-2 and Bcl-xl in the colon declined in the DSS+A group, but these levels increased in the DSS+AN group.Conclusion: The upregulation of miR-223 by agomir administration alleviated colonic inflammation in a DSS-induced colitis model, which was likely mediated by inhibiting the production of proinflammatory cytokines via the IL-6/STAT3 signaling pathway. These findings provide evidence that miR-223 might have potential therapeutic implications in IBD.

Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

2021 ◽  
Author(s):  
fan wan ◽  
Hui Han ◽  
Ruqing Zhong ◽  
Mengyu Wang ◽  
Shanlong Tang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

The purpose of the current study was to investigate the effect of dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ supplementation (3...

Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse

2019 ◽  
Vol 59 (4) ◽  
pp. 1443-1451 ◽  
Author(s):  
Yong Zhang ◽  
Qiangchuan Hou ◽  
Chen Ma ◽  
Jie Zhao ◽  
Haiyan Xu ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Lactobacillus Casei ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice

2019 ◽  
Vol 10 (10) ◽  
pp. 6331-6341 ◽  
Author(s):  
Xiaokun Cai ◽  
Yanhui Han ◽  
Min Gu ◽  
Mingyue Song ◽  
Xian Wu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oral Administration ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation ◽  
Freeze Dried ◽  
Gut Microbiota Dysbiosis

Oral administration of freeze-dried whole cranberry powder via diet inhibited colitis in dextran sodium sulfate-treated mice, which was associated with modification of gut microbiota.

Naringin protects against dextran sodium sulfate-induced colitis in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
E Giner ◽  
M Marin ◽  
C Recio ◽  
J Ríos ◽  
R Giner
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

Comparative effects of STW 5 and STW 5-II in dextran sodium sulfate-induced colitis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MT Khayyal ◽  
W Wadie ◽  
D Weiser ◽  
H Abdel-Aziz
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate
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