Transition metal-catalyzed sp3 C–H activation and intramolecular C–N coupling to construct nitrogen heterocyclic scaffolds

2019 ◽  
Vol 55 (87) ◽  
pp. 13048-13065 ◽  
Author(s):  
Ming Zhang ◽  
Qiuhong Wang ◽  
Yiyuan Peng ◽  
Zhiyuan Chen ◽  
Changfeng Wan ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Transition Metal ◽  
Nitrogen Heterocycles ◽  
Synthetic Organic Chemistry ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Nitrogen Heterocyclic

Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry.

Transition metal-catalyzed arylation of unstrained C−C single bonds

2021 ◽  
Author(s):  
Long Yang ◽  
Wuxin Zhou ◽  
Qiang Li ◽  
Xiangge Zhou
Keyword(s):  
Organic Chemistry ◽  
Transition Metal ◽  
Bond Activation ◽  
Important Research ◽  
Carbon Bond ◽  
Research Areas ◽  
Carbon Carbon Bond ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Single Bonds

Carbon−carbon bond activation is one of the most challenging and important research areas in organic chemistry. Selective C−C bond activation of unstrained substrates is difficult to achieve owing to its...

scholarly journals Opportunities and challenges for direct C–H functionalization of piperazines

2016 ◽  
Vol 12 ◽  
pp. 702-715 ◽  
Author(s):  
Zhishi Ye ◽  
Kristen E Gettys ◽  
Mingji Dai
Keyword(s):  
Transition Metal ◽  
Small Molecule ◽  
Heterocyclic Compounds ◽  
Structural Diversity ◽  
Synthetic Methods ◽  
Photoredox Catalysis ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Nitrogen Heterocyclic

Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend structural diversity to this privileged drug scaffold. Multiple approaches such as those involving α-lithiation trapping, transition-metal-catalyzed α-C–H functionalizations, and photoredox catalysis are discussed. We also highlight the difficulties experienced when successful methods for α-C–H functionalization of acyclic amines and saturated mono-nitrogen heterocyclic compounds (such as piperidines and pyrrolidines) were applied to piperazine substrates.

scholarly journals Combined Enzyme- and Transition Metal-Catalyzed Strategy for the Enantioselective Syntheses of Nitrogen Heterocycles: (−)-Coniine, DAB-1, and Nectrisine

ACS Omega ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 2005-2014
Author(s):  
Donald R. Deardorff ◽  
Scott W. Niman ◽  
Mark I. Paulsen ◽  
Anasheh Sookezian ◽  
Meghan E. Whalen ◽  
...  
Keyword(s):  
Transition Metal ◽  
Nitrogen Heterocycles ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Enantioselective Syntheses

scholarly journals Recent advances in the synthesis of bridgehead (or ring-junction) nitrogen heterocycles via transition metal-catalyzed C–H bond activation and functionalization

2020 ◽  
Vol 7 (19) ◽  
pp. 3067-3099
Author(s):  
Biao Nie ◽  
Wanqing Wu ◽  
Yingjun Zhang ◽  
Huanfeng Jiang ◽  
Ji Zhang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Nitrogen Heterocycles ◽  
Fused Heterocycles ◽  
Recent Advances ◽  
Ring Junction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Bridgehead Nitrogen

An update on recent advances in the synthesis of bridgehead nitrogen fused heterocycles via transition metal-catalyzed C–H activation and functionalization is reported.

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

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