Diazo Compounds: Versatile Synthons for the Synthesis of Nitrogen Heterocycles via Transition Metal-Catalyzed Cascade C-H Activation/Carbene Insertion/Annulation Reactions

2018 ◽  
Vol 361 (5) ◽  
pp. 919-944 ◽  
Author(s):  
Yunyu Xiang ◽  
Cong Wang ◽  
Qiuping Ding ◽  
Yiyuan Peng
Keyword(s):  
Transition Metal ◽  
Nitrogen Heterocycles ◽  
Diazo Compounds ◽  
Carbene Insertion ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Transition metal-catalyzed sp3 C–H activation and intramolecular C–N coupling to construct nitrogen heterocyclic scaffolds

2019 ◽  
Vol 55 (87) ◽  
pp. 13048-13065 ◽  
Author(s):  
Ming Zhang ◽  
Qiuhong Wang ◽  
Yiyuan Peng ◽  
Zhiyuan Chen ◽  
Changfeng Wan ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Transition Metal ◽  
Nitrogen Heterocycles ◽  
Synthetic Organic Chemistry ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Nitrogen Heterocyclic

Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry.

Chiral proton-transfer shuttle catalysts for carbene insertion reactions

2018 ◽  
Vol 16 (17) ◽  
pp. 3087-3094 ◽  
Author(s):  
Yuan-Yuan Ren ◽  
Shou-Fei Zhu ◽  
Qi-Lin Zhou
Keyword(s):  
Transition Metal ◽  
Proton Transfer ◽  
Insertion Reactions ◽  
Carbene Insertion ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The development of chiral proton-transfer shuttles provides a totally new enantiocontrol strategy for transition metal-catalyzed asymmetric carbene insertion reactions.

Transition-Metal-Catalyzed Cross-Coupling with Non-Diazo Carbene Precursors

Synlett ◽  
2018 ◽  
Vol 30 (05) ◽  
pp. 542-551 ◽  
Author(s):  
Jianbo Wang ◽  
Kang Wang
Keyword(s):  
Transition Metal ◽  
Cross Coupling ◽  
Diazo Compounds ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Carbon Carbon Bond ◽  
Palladium Catalyzed ◽  
Fischer Carbenes ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Transition-metal-catalyzed cross-coupling reactions through metal carbene migratory insertion have emerged as powerful methodology for carbon–carbon bond constructions. Typically, diazo compounds (or in situ generated diazo compounds from N-tosylhydrazones) have been employed as the metal carbene precursors for this type of cross-coupling reactions. Recently, cross-coupling reactions employing non-diazo carbene precursors, such as conjugated ene-yne-ketones, allenyl ketones, alkynes, cyclopropenes, and Cr(0) Fischer carbenes, have been developed. This account will summarize our efforts in the development of transition-metal-catalyzed cross-coupling reactions with these non-diazo carbene precursors.1 Introduction2 Cross-Coupling with Ene-yne-ketones, Allenyl Ketones, and Alkynes3 Cross-Coupling Involving Ring-Opening of Cyclopropenes4 Palladium-Catalyzed Cross-Coupling with Chromium(0) Fischer Carbenes5 Conclusion

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