Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

2020 ◽  
Vol 8 (10) ◽  
pp. 2756-2770 ◽  
Author(s):  
Ratchapol Jenjob ◽  
Treethip Phakkeeree ◽  
Daniel Crespy
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Shell Particles

Core–shell particles offer significant advantages in their use for bioimaging and biosensors.

New core-shell hydroxyapatite/Gum-Acacia nanocomposites for drug delivery and tissue engineering applications

2018 ◽  
Vol 92 ◽  
pp. 685-693 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T.S. Nellaiappan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Engineering Applications ◽  
Gum Acacia

scholarly journals Dual-pH-sensitivity and tumour targeting core–shell particles for intracellular drug delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 851-860 ◽  
Author(s):  
Weiju Hao ◽  
Yinxing Shen ◽  
Danyang Liu ◽  
Yazhuo Shang ◽  
Junqi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitivity ◽  
Core Shell ◽  
Tumour Targeting ◽  
Principal Problem ◽  
Intracellular Drug Delivery ◽  
Shell Particles

The principal problem in the area of drug delivery is achieving better selectivity and controllability.

scholarly journals Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1959
Author(s):  
Seiya Suzuki ◽  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Katsuya Kato ◽  
Ayae Sugawara-Narutaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Loading ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Vitamin K1 ◽  
Acidic Conditions ◽  
Living Organisms ◽  
Shell Particles ◽  
Hydrophobic Substance

Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The particles were 40–80 nm in diameter with a PLA core and a HAp shell. The particle size increased with an increase in the vitamin K1 loading. The drug-loading capacity (LC) value of the particles, an indicator of their drug-loading ability, was approximately 250%, which is higher than the previously reported values. The amount of vitamin K1 released from the particles increased as the pH of the soaking solution decreased because the HAp shell easily dissolved under the acidic conditions. The PLA/HAp particles prepared in this work were found to be promising candidates for drug delivery carriers because of their excellent drug-loading ability and pH sensitivity.

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application

2021 ◽  
Vol 27 ◽  
Author(s):  
Nasrullah Shah ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
Zubair Ullah Khan
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Water Soluble ◽  
Core Shell ◽  
Special Focus ◽  
Tissue Engineering Scaffolds ◽  
Shell Nanoparticles ◽  
Composites Materials ◽  
Shell Particles ◽  
Core Shell Nanoparticles

: Polyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based composites materials and then concentrated on the PEG-based core-shell nanoparticles for biomedical applications specifically their use in drug delivery.

Advantages and challenges offered by biofunctional core–shell fiber systems for tissue engineering and drug delivery

2016 ◽  
Vol 21 (8) ◽  
pp. 1243-1256 ◽  
Author(s):  
Laura E. Sperling ◽  
Karina P. Reis ◽  
Patricia Pranke ◽  
Joachim H. Wendorff
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell

Microfluidic conceived pH sensitive core–shell particles for dual drug delivery

2015 ◽  
Vol 478 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Ikram Ullah Khan ◽  
Lukas Stolch ◽  
Christophe A. Serra ◽  
Nicolas Anton ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Core Shell ◽  
Shell Particles ◽  
Dual Drug

scholarly journals Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2008 ◽  
Author(s):  
Muhammad Faiq Abdullah ◽  
Tamrin Nuge ◽  
Andri Andriyana ◽  
Bee Chin Ang ◽  
Farina Muhamad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Clinical Applications ◽  
Bioactive Molecules ◽  
Core Shell ◽  
Therapeutic Effects ◽  
Design Requirement ◽  
Preparation Methods ◽  
Controllable Release ◽  
Future Direction

The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

Novel co-axial prilling technique for the development of core–shell particles as delayed drug delivery systems

2014 ◽  
Vol 87 (3) ◽  
pp. 541-547 ◽  
Author(s):  
Pasquale Del Gaudio ◽  
Giulia Auriemma ◽  
Paola Russo ◽  
Teresa Mencherini ◽  
Pietro Campiglia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Core Shell ◽  
Shell Particles
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