scholarly journals Dual-pH-sensitivity and tumour targeting core–shell particles for intracellular drug delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 851-860 ◽  
Author(s):  
Weiju Hao ◽  
Yinxing Shen ◽  
Danyang Liu ◽  
Yazhuo Shang ◽  
Junqi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitivity ◽  
Core Shell ◽  
Tumour Targeting ◽  
Principal Problem ◽  
Intracellular Drug Delivery ◽  
Shell Particles

The principal problem in the area of drug delivery is achieving better selectivity and controllability.

scholarly journals Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Ayae Sugawara-Narutaki ◽  
Katsuya Kato ◽  
Fukue Nagata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Shell Nanoparticles ◽  
The Core ◽  
Core Shell Nanoparticles

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. In our previous work, core–shell nanoparticles composed of the biodegradable polymer poly(lactic acid) (PLA) and the widely used inorganic biomaterial hydroxyapatite (HAp, which exhibits pH sensitivity) were prepared using a surfactant-free method. These PLA/HAp core–shell nanoparticles could load 750 wt% of a hydrophobic model drug. In this work, the properties of the PLA/HAp core–shell nanoparticles loaded with the anti-cancer drug paclitaxel (PTX) were thoroughly investigated in vitro . Because the PTX-containing nanoparticles were approximately 80 nm in size, they can be expected to facilitate efficient drug delivery via the EPR effect. The core–shell nanoparticles were cytotoxic towards cancer cells (4T1). This was due to the pH sensitivity of the HAp shell, which is stable in neutral conditions and dissolves in acidic conditions. The cytotoxic activity of the PTX-loaded nanoparticles was sustained for up to 48 h, which was suitable for tumour growth inhibition. These results suggest that the core–shell nanoparticles can be suitable drug carriers for various water-insoluble drugs.

Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

2020 ◽  
Vol 8 (10) ◽  
pp. 2756-2770 ◽  
Author(s):  
Ratchapol Jenjob ◽  
Treethip Phakkeeree ◽  
Daniel Crespy
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Shell Particles

Core–shell particles offer significant advantages in their use for bioimaging and biosensors.

scholarly journals Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1959
Author(s):  
Seiya Suzuki ◽  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Katsuya Kato ◽  
Ayae Sugawara-Narutaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Loading ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Vitamin K1 ◽  
Acidic Conditions ◽  
Living Organisms ◽  
Shell Particles ◽  
Hydrophobic Substance

Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The particles were 40–80 nm in diameter with a PLA core and a HAp shell. The particle size increased with an increase in the vitamin K1 loading. The drug-loading capacity (LC) value of the particles, an indicator of their drug-loading ability, was approximately 250%, which is higher than the previously reported values. The amount of vitamin K1 released from the particles increased as the pH of the soaking solution decreased because the HAp shell easily dissolved under the acidic conditions. The PLA/HAp particles prepared in this work were found to be promising candidates for drug delivery carriers because of their excellent drug-loading ability and pH sensitivity.

scholarly journals A novel corona core‑shell nanoparticle for enhanced intracellular drug delivery

2020 ◽  
Author(s):  
Jianwei Jiang ◽  
Xiaoming Zhong ◽  
Hongyan Zhang ◽  
Chunlei Wang
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Intracellular Drug Delivery

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application

2021 ◽  
Vol 27 ◽  
Author(s):  
Nasrullah Shah ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
Zubair Ullah Khan
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Water Soluble ◽  
Core Shell ◽  
Special Focus ◽  
Tissue Engineering Scaffolds ◽  
Shell Nanoparticles ◽  
Composites Materials ◽  
Shell Particles ◽  
Core Shell Nanoparticles

: Polyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based composites materials and then concentrated on the PEG-based core-shell nanoparticles for biomedical applications specifically their use in drug delivery.

Microfluidic conceived pH sensitive core–shell particles for dual drug delivery

2015 ◽  
Vol 478 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Ikram Ullah Khan ◽  
Lukas Stolch ◽  
Christophe A. Serra ◽  
Nicolas Anton ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Core Shell ◽  
Shell Particles ◽  
Dual Drug

Core-Shell-Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery

2010 ◽  
Vol 31 (13) ◽  
pp. 1201-1206 ◽  
Author(s):  
Yu-Cai Wang ◽  
Yang Li ◽  
Tian-Meng Sun ◽  
Meng-Hua Xiong ◽  
Juan Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Intracellular Drug Delivery ◽  
Cross Linkage

Novel co-axial prilling technique for the development of core–shell particles as delayed drug delivery systems

2014 ◽  
Vol 87 (3) ◽  
pp. 541-547 ◽  
Author(s):  
Pasquale Del Gaudio ◽  
Giulia Auriemma ◽  
Paola Russo ◽  
Teresa Mencherini ◽  
Pietro Campiglia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Core Shell ◽  
Shell Particles

Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery

2015 ◽  
Vol 6 (3) ◽  
pp. 397-405 ◽  
Author(s):  
Jinjin Chen ◽  
Jianxun Ding ◽  
Ying Zhang ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electrostatic Interaction ◽  
Ph Sensitivity ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
On Demand ◽  
Intracellular Targeting ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

Four polyion complex micelles with gradient pH-sensitivity were prepared through the electrostatic interaction for adjustable “on demand” intracellular targeting chemotherapy.

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