Advantages and challenges offered by biofunctional core–shell fiber systems for tissue engineering and drug delivery

2016 ◽  
Vol 21 (8) ◽  
pp. 1243-1256 ◽  
Author(s):  
Laura E. Sperling ◽  
Karina P. Reis ◽  
Patricia Pranke ◽  
Joachim H. Wendorff
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell

New core-shell hydroxyapatite/Gum-Acacia nanocomposites for drug delivery and tissue engineering applications

2018 ◽  
Vol 92 ◽  
pp. 685-693 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T.S. Nellaiappan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Engineering Applications ◽  
Gum Acacia

Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

2020 ◽  
Vol 8 (10) ◽  
pp. 2756-2770 ◽  
Author(s):  
Ratchapol Jenjob ◽  
Treethip Phakkeeree ◽  
Daniel Crespy
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Shell Particles

Core–shell particles offer significant advantages in their use for bioimaging and biosensors.

scholarly journals Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2008 ◽  
Author(s):  
Muhammad Faiq Abdullah ◽  
Tamrin Nuge ◽  
Andri Andriyana ◽  
Bee Chin Ang ◽  
Farina Muhamad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Clinical Applications ◽  
Bioactive Molecules ◽  
Core Shell ◽  
Therapeutic Effects ◽  
Design Requirement ◽  
Preparation Methods ◽  
Controllable Release ◽  
Future Direction

The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

2013 ◽  
Vol 20 (28) ◽  
pp. 3488-3499 ◽  
Author(s):  
Yon Jung ◽  
Hwanbum Lee ◽  
Jae Kim ◽  
Eun Koo ◽  
Keun Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

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